STRINGSTRING
LOC103014668 LOC103014668 LOC103001311 LOC103001311 RAC2 RAC2 SMAD3 SMAD3 MAP2K1 MAP2K1 TP53 TP53 SOS1 SOS1 BAX BAX BBC3 BBC3 RHOA RHOA NRAS NRAS MAP2K2 MAP2K2 PIK3CD PIK3CD MTOR MTOR PIK3CB PIK3CB CCND1 CCND1 HRAS HRAS RPS6KB2 RPS6KB2 GADD45A GADD45A LOC103003361 LOC103003361 TCF7L2 TCF7L2 BAD BAD CASP9 CASP9 TCF7L1 TCF7L1 TGFA TGFA POLK POLK PIK3R1 PIK3R1 AKT1 AKT1 GADD45B GADD45B MAPK10 MAPK10 CASP3 CASP3 MAPK8 MAPK8 MSH3 MSH3 EREG EREG AKT2 AKT2 AREG AREG ARAF ARAF DDB2 DDB2 RALB RALB GSK3B GSK3B AKT3 AKT3 TGFB3 TGFB3 FOS FOS GRB2 GRB2 BIRC5 BIRC5 AXIN2 AXIN2 RAC3 RAC3 MAPK3 MAPK3 RAC1 RAC1 BAK1 BAK1 RALA RALA EGFR EGFR MYC MYC MSH2 MSH2 MSH6 MSH6 RPS6KB1 RPS6KB1 LOC103017780 LOC103017780 LOC102999215 LOC102999215 LEF1 LEF1 EGF EGF TGFBR2 TGFBR2 BCL2 BCL2 APC APC PMAIP1 PMAIP1 APPL1 APPL1 RAF1 RAF1 SOS2 SOS2 CTNNB1 CTNNB1 GADD45G GADD45G RALGDS RALGDS KRAS KRAS PIK3R2 PIK3R2 MAPK1 MAPK1 TGFBR1 TGFBR1 SMAD2 SMAD2 SMAD4 SMAD4 DCC DCC BCL2L11 BCL2L11 CDKN1A CDKN1A APC2 APC2 PIK3CA PIK3CA TGFB1 TGFB1 LOC103008077 LOC103008077 MLH1 MLH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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LOC103014668Transcription factor AP-1; Belongs to the bZIP family. (253 aa)
LOC103001311Transcription factor AP-1-like. (199 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1001 aa)
BAXApoptosis regulator BAX. (192 aa)
BBC3Bcl-2-binding component 3. (140 aa)
RHOATransforming protein RhoA. (193 aa)
NRASGTPase NRas. (189 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1042 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CCND1G1/S-specific cyclin-D1 isoform X1; Belongs to the cyclin family. (214 aa)
HRASGTPase HRas isoform X1. (196 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (590 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (171 aa)
LOC103003361Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (515 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (414 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (439 aa)
TGFAProtransforming growth factor alpha. (145 aa)
POLKDNA polymerase kappa isoform X1. (877 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (476 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1122 aa)
EREGProepiregulin isoform X1. (163 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AREGAmphiregulin isoform X1. (254 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
RALBRas-related protein Ral-B isoform X1. (163 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
FOSProto-oncogene c-Fos. (380 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (143 aa)
AXIN2Axin-2. (543 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (206 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (194 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
RALARas-related protein Ral-A. (206 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1360 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
LOC103017780Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC102999215Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1215 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
APCAdenomatous polyposis coli protein isoform X1. (2865 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (74 aa)
APPL1DCC-interacting protein 13-alpha isoform X1. (672 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1272 aa)
CTNNB1Catenin beta-1. (767 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
RALGDSLOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator. (813 aa)
KRASGTPase KRas isoform X3. (227 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (700 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
DCCLOW QUALITY PROTEIN: netrin receptor DCC. (1446 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
APC2LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2. (1582 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
LOC103008077Phosphatidylinositol 3-kinase regulatory subunit gamma. (484 aa)
MLH1DNA mismatch repair protein Mlh1. (778 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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