STRINGSTRING
RAC2 RAC2 SMAD3 SMAD3 MAP2K1 MAP2K1 TP53 TP53 PLD2 PLD2 BAX BAX PIK3CD PIK3CD MTOR MTOR PIK3CB PIK3CB CCND1 CCND1 RELA RELA RPS6KB2 RPS6KB2 STAT1 STAT1 GADD45A GADD45A NFKB1 NFKB1 BAD BAD CDC42 CDC42 CASP9 CASP9 TGFA TGFA POLK POLK PIK3R1 PIK3R1 AKT1 AKT1 GADD45B GADD45B LOC103012968 LOC103012968 MAPK10 MAPK10 ERBB2 ERBB2 LOC102997405 LOC102997405 MAPK8 MAPK8 CDK4 CDK4 AKT2 AKT2 ARAF ARAF RAD51 RAD51 DDB2 DDB2 RALB RALB AKT3 AKT3 ARHGEF6 ARHGEF6 TGFB3 TGFB3 RAC3 RAC3 MAPK3 MAPK3 RAC1 RAC1 RB1 RB1 BAK1 BAK1 CHUK CHUK RALA RALA EGFR EGFR RPS6KB1 RPS6KB1 EGF EGF TGFBR2 TGFBR2 RAF1 RAF1 BCL2L1 BCL2L1 E2F1 E2F1 GADD45G GADD45G RALGDS RALGDS KRAS KRAS PIK3R2 PIK3R2 CDK6 CDK6 RALBP1 RALBP1 MAPK1 MAPK1 TGFBR1 TGFBR1 E2F3 E2F3 SMAD2 SMAD2 SMAD4 SMAD4 PLD1 PLD1 CDKN1A CDKN1A PIK3CA PIK3CA BRCA2 BRCA2 VEGFA VEGFA TGFB1 TGFB1 JAK1 JAK1 LOC103008077 LOC103008077 E2F2 E2F2 LOC103008157 LOC103008157
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X1. (192 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
PLD2Phospholipase. (933 aa)
BAXApoptosis regulator BAX. (192 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1042 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CCND1G1/S-specific cyclin-D1 isoform X1; Belongs to the cyclin family. (214 aa)
RELATranscription factor p65 isoform X1. (520 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (590 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (171 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (974 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (414 aa)
TGFAProtransforming growth factor alpha. (145 aa)
POLKDNA polymerase kappa isoform X1. (877 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (476 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
LOC103012968Cyclin-dependent kinase inhibitor 2A. (109 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
LOC102997405Signal transducer and activator of transcription. (783 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (303 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
RALBRas-related protein Ral-B isoform X1. (163 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6. (752 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (206 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (194 aa)
RB1Retinoblastoma-associated protein. (816 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
RALARas-related protein Ral-A. (206 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1215 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (250 aa)
E2F1Transcription factor E2F1. (361 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
RALGDSLOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator. (813 aa)
KRASGTPase KRas isoform X3. (227 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (700 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RALBP1ralA-binding protein 1. (635 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
E2F3Transcription factor E2F3. (340 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
PLD1Phospholipase. (1075 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3340 aa)
VEGFAVascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (186 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
JAK1Tyrosine-protein kinase. (1155 aa)
LOC103008077Phosphatidylinositol 3-kinase regulatory subunit gamma. (484 aa)
E2F2Transcription factor E2F2. (414 aa)
LOC103008157Signal transducer and activator of transcription. (793 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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