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IL23R IL23R IL12RB2 IL12RB2 LOC103014668 LOC103014668 LOC103001311 LOC103001311 SMAD3 SMAD3 GATA3 GATA3 NOD2 NOD2 RELA RELA STAT1 STAT1 STAT4 STAT4 IL10 IL10 IL12B IL12B TLR5 TLR5 IL18RAP IL18RAP IL18R1 IL18R1 IL2 IL2 IL21 IL21 NFATC1 NFATC1 IL18 IL18 NFKB1 NFKB1 TBX21 TBX21 LOC102997405 LOC102997405 TLR4 TLR4 RORC RORC STAT6 STAT6 IL23A IL23A FOXP3 FOXP3 IL2RG IL2RG IFNGR2 IFNGR2 IL6 IL6 TGFB3 TGFB3 IL4R IL4R IL21R IL21R LOC103009822 LOC103009822 LOC103010705 LOC103010705 LOC103008197 LOC103008197 LOC103012629 LOC103012629 IL12A IL12A IL5 IL5 IL4 IL4 TLR2 TLR2 IFNGR1 IFNGR1 LOC103007035 LOC103007035 LOC103007833 LOC103007833 TNF TNF IL17A IL17A LOC103007535 LOC103007535 IL17F IL17F IFNG IFNG IL22 IL22 IL12RB1 IL12RB1 SMAD2 SMAD2 IL1B IL1B IL1A IL1A TGFB1 TGFB1 LOC103008157 LOC103008157 RORA RORA IL13 IL13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL23RInterleukin-23 receptor isoform X1. (630 aa)
IL12RB2Interleukin-12 receptor subunit beta-2. (861 aa)
LOC103014668Transcription factor AP-1; Belongs to the bZIP family. (253 aa)
LOC103001311Transcription factor AP-1-like. (199 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X2. (1013 aa)
RELATranscription factor p65 isoform X1. (520 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
IL10Interleukin-10. (178 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
TLR5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
IL18RAPInterleukin-18 receptor accessory protein isoform X1. (624 aa)
IL18R1Interleukin-18 receptor 1 isoform X1. (539 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (901 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (175 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (974 aa)
TBX21T-box transcription factor TBX21. (379 aa)
LOC102997405Signal transducer and activator of transcription. (783 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
RORCNuclear receptor ROR-gamma. (507 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
IL23AInterleukin-23 subunit alpha. (190 aa)
FOXP3LOW QUALITY PROTEIN: forkhead box protein P3. (432 aa)
IL2RGCytokine receptor common subunit gamma isoform X1. (384 aa)
IFNGR2Interferon gamma receptor 2. (351 aa)
IL6Interleukin-6. (208 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
IL4RInterleukin-4 receptor subunit alpha isoform X1. (832 aa)
IL21RInterleukin-21 receptor. (540 aa)
LOC103009822HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (261 aa)
LOC103010705HLA class II histocompatibility antigen, DM beta chain isoform X1. (273 aa)
LOC103008197HLA class II histocompatibility antigen, DO alpha chain. (250 aa)
LOC103012629HLA class II histocompatibility antigen, DO beta chain-like. (270 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
IFNGR1Interferon gamma receptor 1. (502 aa)
LOC103007035DLA class II histocompatibility antigen, DR-1 beta chain-like. (176 aa)
LOC103007833HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IL17Ainterleukin-17A. (153 aa)
LOC103007535DLA class II histocompatibility antigen, DR-1 beta chain-like. (265 aa)
IL17Finterleukin-17F. (204 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL22Interleukin-22. (190 aa)
IL12RB1Interleukin-12 receptor subunit beta-1. (726 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
LOC103008157Signal transducer and activator of transcription. (793 aa)
RORANuclear receptor ROR-alpha. (386 aa)
IL13Interleukin-13. (146 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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