STRINGSTRING
pckA pckA gpmA gpmA pta pta rbsK rbsK mqo mqo pgi pgi edd edd pgl pgl zwf zwf gntK gntK serA-2 serA-2 ppdK ppdK zwf-2 zwf-2 ilvE1 ilvE1 leuA1 leuA1 ilvD ilvD rpe rpe gltA gltA eno eno pdhA1 pdhA1 pdhA2 pdhA2 Arad_2249 Arad_2249 lpdA lpdA lipA lipA gnd gnd cisZ cisZ Arad_2446 Arad_2446 tpiA tpiA lipB lipB rpe-2 rpe-2 lldD1 lldD1 Arad_2613 Arad_2613 gnd-2 gnd-2 dme dme rpiA rpiA fumC fumC fumB fumB ilvC ilvC ilvN ilvN ilvB ilvB glcD-2 glcD-2 pfk pfk ilvG ilvG prsAch prsAch leuA leuA kdgK kdgK lldD3 lldD3 ilvD-2 ilvD-2 bkdA2 bkdA2 ilvD-3 ilvD-3 Arad_3558 Arad_3558 serA-3 serA-3 serC serC tkt tkt gap gap pgk pgk fbaB fbaB pyk pyk glgP glgP glgB glgB glgC glgC glgA glgA pgm pgm glgX glgX eda eda tal tal fdsD fdsD fdhA fdhA fdsB fdsB fdsG fdsG lpdA-2 lpdA-2 sucB sucB sucA sucA sucD sucD sucC sucC mdh mdh sdhB sdhB sdhA sdhA sdhD sdhD sdhC sdhC acnA acnA leuC leuC pyc-2 pyc-2 leuD leuD leuB leuB acsA acsA ach1 ach1 Arad_7183 Arad_7183 ilvG-2 ilvG-2 Arad_7347 Arad_7347 Arad_7471 Arad_7471 Arad_7566 Arad_7566 Arad_7568 Arad_7568 ackA ackA serA-4 serA-4 Arad_7660 Arad_7660 leuA1-2 leuA1-2 ilvG-3 ilvG-3 selA-2 selA-2 tpiA-3 tpiA-3 tktB tktB tktA tktA ilvD-4 ilvD-4 Arad_8983 Arad_8983 Arad_9169 Arad_9169 gabDf1 gabDf1 Arad_9475 Arad_9475 rpe-3 rpe-3 Arad_9705 Arad_9705 ilvE ilvE rbsK-2 rbsK-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa)
gpmAPhosphoglycerate mutase protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (211 aa)
ptaPhosphate acetyltransferase. (761 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (299 aa)
mqoMalate:quinone oxidoreductase. (572 aa)
pgiGlucose-6-phosphate isomerase protein; Belongs to the GPI family. (541 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (607 aa)
pgl6-phosphogluconolactonase protein; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (240 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
gntKGluconokinase protein. (162 aa)
serA-2D-3-phosphoglycerate dehydrogenase protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (412 aa)
ppdKPyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (888 aa)
zwf-2Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (506 aa)
ilvE1Branched-chain-amino-acid aminotransferase protein. (295 aa)
leuA12-isopropylmalate synthase protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (612 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
gltACitrate synthase I; Belongs to the citrate synthase family. (429 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
pdhA1Pyruvate dehydrogenase alpha subunit protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (347 aa)
pdhA2Pyruvate dehydrogenase beta subunit protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (458 aa)
Arad_2249Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (445 aa)
lpdADihydrolipoamide dehydrogenase. (481 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (323 aa)
gnd6-phosphogluconate dehydrogenase (decarboxylating). (341 aa)
cisZCitrate synthase protein. (377 aa)
Arad_2446Citrate synthase protein; Belongs to the citrate synthase family. (362 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (242 aa)
lipBLipoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (238 aa)
rpe-2Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
lldD1L-lactate dehydrogenase (cytochrome) protein. (381 aa)
Arad_2613Isocitrate dehydrogenase, NADP-dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
gnd-26-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (489 aa)
dmeMalate dehydrogenase (oxaloacetate decarboxylating) (NADP+) protein. (770 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (233 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
fumBFumarate hydratase class I protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (535 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
ilvNAcetolactate synthase, small subunit. (190 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type. (597 aa)
glcD-2Glycolate oxidase, subunit GlcD. (470 aa)
pfk6-phosphofructokinase protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (403 aa)
ilvGAcetolactate synthase II; Belongs to the TPP enzyme family. (552 aa)
prsAchRibose-phosphate pyrophosphokinase protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (570 aa)
kdgK2-dehydro-3-deoxygluconokinase protein. (294 aa)
lldD3L-lactate dehydrogenase (cytochrome) protein. (379 aa)
ilvD-2Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (581 aa)
bkdA22-oxoisovalerate dehydrogenase beta subunit protein. (1107 aa)
ilvD-3Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (603 aa)
Arad_3558UDP-glucose 4-epimerase protein. (328 aa)
serA-3D-3-phosphoglycerate dehydrogenase protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa)
serCPhosphoserine aminotransferase protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (392 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (660 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pgkPhosphoglycerate kinase protein; Belongs to the phosphoglycerate kinase family. (415 aa)
fbaBFructose-bisphosphate aldolase protein. (340 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (479 aa)
glgPGlycogen phosphorylase protein; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (820 aa)
glgB1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (735 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (420 aa)
glgAGlycogen synthase (starch (bacterial glycogen) synthase) protein; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (480 aa)
pgmPhosphoglucomutase protein. (542 aa)
glgXGlycogen debranching enzyme GlgX; Belongs to the glycosyl hydrolase 13 family. (657 aa)
eda4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase protein. (212 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (321 aa)
fdsDNAD-dependent formate dehydrogenase. (85 aa)
fdhAFormate dehydrogenase, alpha subunit. (959 aa)
fdsBFormate dehydrogenase. (518 aa)
fdsGFormate dehydrogenase. (159 aa)
lpdA-2Dihydrolipoamide dehydrogenase. (468 aa)
sucB2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (412 aa)
sucA2-oxoglutarate dehydrogenase, E1 component. (994 aa)
sucDsuccinyl-CoA synthetase alpha subunit protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
sucCsuccinyl-CoA synthetase beta subunit protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
sdhBSuccinate dehydrogenase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
sdhASuccinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (613 aa)
sdhDSuccinate dehydrogenase, hydrophobic membrane anchor protein. (126 aa)
sdhCSuccinate dehydrogenase, cytochrome b556 subunit. (133 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (906 aa)
leuC3-isopropylmalate dehydratase large subunit protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
pyc-2Pyruvate carboxylase protein; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1166 aa)
leuD3-isopropylmalate dehydratase small subunit protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (370 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
ach1Acetyl-CoA hydrolase. (455 aa)
Arad_7183Transcriptional regulator protein. (407 aa)
ilvG-2Acetolactate synthase II; Belongs to the TPP enzyme family. (596 aa)
Arad_7347Aminotransferase class IV. (306 aa)
Arad_7471Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
Arad_7566Aldehyde dehydrogenase protein. (463 aa)
Arad_7568Phosphoketolase protein. (804 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
serA-4D-3-phosphoglycerate dehydrogenase protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (337 aa)
Arad_7660Tartrate dehydrogenase. (357 aa)
leuA1-22-isopropylmalate synthase protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (394 aa)
ilvG-3Acetolactate synthase II. (591 aa)
selA-2L-seryl-tRNA(ser) selenium transferase protein. (398 aa)
tpiA-3Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
tktBTransketolase N-terminal subunit protein. (269 aa)
tktATransketolase C-terminal subunit protein. (318 aa)
ilvD-4Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (578 aa)
Arad_8983Aldolase. (266 aa)
Arad_9169Tartrate dehydrogenase. (347 aa)
gabDf1Succinate semialdehyde dehydrogenase protein; Belongs to the aldehyde dehydrogenase family. (484 aa)
Arad_9475Phosphoglycerate mutase protein; Belongs to the phosphoglycerate mutase family. (248 aa)
rpe-3Ribulose-phosphate 3-epimerase. (241 aa)
Arad_9705Exported protein. (390 aa)
ilvEBranched-chain amino acid aminotransferase. (365 aa)
rbsK-2Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (301 aa)
Your Current Organism:
Agrobacterium radiobacter
NCBI taxonomy Id: 311403
Other names: A. radiobacter K84, Agrobacterium radiobacter K84, Agrobacterium radiobacter str. K84, Agrobacterium radiobacter strain K84, Agrobacterium rhizogenes K84, Agrobacterium tumefaciens K84, Rhizobium radiobacter K84
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.