STRINGSTRING
pyrB pyrB coaE coaE accD accD coaA coaA purC purC Arad_0224 Arad_0224 Arad_0248 Arad_0248 gpmA gpmA glk glk upp upp purU purU guaA1 guaA1 pyrF pyrF coaBC coaBC pyrC pyrC pyrE pyrE pgi pgi Arad_0763 Arad_0763 pyrD pyrD fliI fliI Arad_0962 Arad_0962 Arad_0976 Arad_0976 guaB guaB ribF ribF atpB atpB atpE atpE atpF1 atpF1 atpF atpF purD purD gpmB gpmB Arad_1397 Arad_1397 Arad_1453 Arad_1453 amn amn relA relA purF purF gmk2 gmk2 Arad_1689 Arad_1689 ndk ndk purN purN purM purM Arad_1925 Arad_1925 Arad_1950 Arad_1950 adk adk gpt gpt surE surE pyrH pyrH eno eno pdhA2 pdhA2 Arad_2249 Arad_2249 Arad_2256 Arad_2256 Arad_2258 Arad_2258 mazG mazG coaD coaD pyrG pyrG purB purB purC-2 purC-2 purS purS purQ purQ purL purL Arad_2661 Arad_2661 Arad_2745 Arad_2745 pfk pfk carA carA carB carB apt apt Arad_3385 Arad_3385 bkdA2 bkdA2 Arad_3441 Arad_3441 purA purA Arad_3543 Arad_3543 tkt tkt pgk pgk fbaB fbaB purE purE purK purK pyk pyk purN-2 purN-2 Arad_3937 Arad_3937 Arad_4048 Arad_4048 Arad_4164 Arad_4164 hpt hpt accA accA Arad_4259 Arad_4259 atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH frcK-2 frcK-2 sucB sucB sucA sucA tesB tesB citEch citEch purH purH acsA acsA ach1 ach1 Arad_7095 Arad_7095 matB matB ackA ackA Arad_8020 Arad_8020 Arad_8026 Arad_8026 Arad_8072 Arad_8072 Arad_8187 Arad_8187 purU-2 purU-2 Arad_8606 Arad_8606 purU-3 purU-3 hrcN hrcN Arad_8983 Arad_8983 Arad_9350 Arad_9350 Arad_9475 Arad_9475 udp udp Arad_9971 Arad_9971
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (318 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (205 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (303 aa)
coaAPantothenate kinase. (331 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (329 aa)
Arad_0224Purine/pyrimidine phosphoribosyltransferase protein. (226 aa)
Arad_0248Phosphoglycerate mutase protein. (188 aa)
gpmAPhosphoglycerate mutase protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (211 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (340 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
guaA1GMP synthase - glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. (520 aa)
pyrFOrotidine 5'-phosphate decarboxylase protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (230 aa)
coaBCPhosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa)
pyrCDihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (346 aa)
pyrEOrotate phosphoribosyltransferase protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (232 aa)
pgiGlucose-6-phosphate isomerase protein; Belongs to the GPI family. (541 aa)
Arad_0763Conserved hypothetical protein. (293 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (362 aa)
fliIH(+)-transporting ATP synthase. (462 aa)
Arad_0962acetoacetyl-CoA synthase. (650 aa)
Arad_0976Glyoxalase protein. (115 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (494 aa)
ribFRiboflavin biosynthesis protein RibF; Belongs to the ribF family. (327 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (250 aa)
atpEATP synthase protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa)
atpF1ATP synthase protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (197 aa)
atpFATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (163 aa)
purDPhosphoribosylamine-glycine ligase protein; Belongs to the GARS family. (423 aa)
gpmBPhosphoglycerate mutase protein; Belongs to the phosphoglycerate mutase family. (198 aa)
Arad_1397Glyoxalase protein. (259 aa)
Arad_1453Glyoxalase/bleomycin resistance protein/dioxygenase. (125 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (500 aa)
relAGuanosine-3; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (754 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (494 aa)
gmk2Guanylate kinase (GMP kinase) protein; Essential for recycling GMP and indirectly, cGMP. (220 aa)
Arad_1689Conserved hypothetical protein. (182 aa)
ndkNucleoside-diphosphate-kinase protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (225 aa)
purM5'-phosphoribosyl-5-aminoimidazole synthetase protein. (357 aa)
Arad_1925acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
Arad_1950Conserved hypothetical protein. (168 aa)
adkAdenylate kinase (ATP-AMP transphosphorylase) protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa)
gptXanthine-guanine phosphoribosyltransferase protein; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (165 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
pdhA2Pyruvate dehydrogenase beta subunit protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (458 aa)
Arad_2249Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (445 aa)
Arad_2256DNA topology modulation kinase FlaR-like protein. (199 aa)
Arad_2258DNA topology modulation kinase FlaR-like protein. (188 aa)
mazGMazG protein. (278 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (167 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (566 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (433 aa)
purC-2Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (254 aa)
purSPhosphoribosylformylglycinamidine synthase, purS protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (80 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (223 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (743 aa)
Arad_2661Conserved hypothetical protein. (132 aa)
Arad_2745acyl-CoA hydrolase protein. (129 aa)
pfk6-phosphofructokinase protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (403 aa)
carACarbamoyl-phosphate synthase small chain (glutamine-hydrolysing) protein; Belongs to the CarA family. (402 aa)
carBCarbamoyl-phosphate synthase large chain (ammonia chain) protein; Belongs to the CarB family. (1161 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (180 aa)
Arad_3385Phosphoglycerate mutase protein. (193 aa)
bkdA22-oxoisovalerate dehydrogenase beta subunit protein. (1107 aa)
Arad_3441Dihydroorotate oxidase protein. (437 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa)
Arad_3543Dioxygenase protein. (310 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (660 aa)
pgkPhosphoglycerate kinase protein; Belongs to the phosphoglycerate kinase family. (415 aa)
fbaBFructose-bisphosphate aldolase protein. (340 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (352 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (479 aa)
purN-2Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (199 aa)
Arad_3937Conserved hypothetical protein. (118 aa)
Arad_4048Conserved hypothetical protein. (145 aa)
Arad_4164acetyl-CoA synthetase protein. (548 aa)
hptHypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (182 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa)
Arad_4259DNA topology modulation kinase FlaR-like protein. (170 aa)
atpCATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (135 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (485 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (294 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (510 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (194 aa)
frcK-2Pantothenate kinase protein. (242 aa)
sucB2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (412 aa)
sucA2-oxoglutarate dehydrogenase, E1 component. (994 aa)
tesBacyl-CoA thioesterase II. (294 aa)
citEchCitrate lyase; Belongs to the HpcH/HpaI aldolase family. (304 aa)
purHBifunctional purine biosynthesis protein PurH. (538 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa)
ach1Acetyl-CoA hydrolase. (455 aa)
Arad_7095CTP synthase protein. (408 aa)
matBlong-chain-fatty-acid-CoA ligase protein. (910 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
Arad_8020Adenine phosphoribosyltransferase. (210 aa)
Arad_8026Phosphoribosyltransferase. (237 aa)
Arad_8072AIR synthase protein. (325 aa)
Arad_8187Aldolase protein. (274 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
Arad_8606Aldolase protein. (280 aa)
purU-3Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
hrcNType III secretion system ATP synthase protein. (439 aa)
Arad_8983Aldolase. (266 aa)
Arad_9350Glyoxalase protein. (123 aa)
Arad_9475Phosphoglycerate mutase protein; Belongs to the phosphoglycerate mutase family. (248 aa)
udpUridine phosphorylase. (277 aa)
Arad_9971Ankyrin repeat protein off7. (160 aa)
Your Current Organism:
Agrobacterium radiobacter
NCBI taxonomy Id: 311403
Other names: A. radiobacter K84, Agrobacterium radiobacter K84, Agrobacterium radiobacter str. K84, Agrobacterium radiobacter strain K84, Agrobacterium rhizogenes K84, Agrobacterium tumefaciens K84, Rhizobium radiobacter K84
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.