(16 nodes) Ubiquitin-dependent ERAD pathway network (Tetrahymena thermophila)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I7M018_TETTS	Ubiquitin-conjugating enzyme. (448 aa)
	I7M3G1_TETTS	Heat shock protein HSP90. (794 aa)
	I7MLE0_TETTS	OTU-like cysteine protease. (308 aa)
	I7MLP7_TETTS	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family. (766 aa)
	Q22AI2_TETTS	Meckelin. (1035 aa)
	Q236U2_TETTS	bVLRF1 domain-containing protein. (383 aa)
	Q23K99_TETTS	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (249 aa)
	Q22CR7_TETTS	Meckelin. (946 aa)
	Q23QU7_TETTS	Ubiquitin elongating factor core protein. (1096 aa)
	Q22TE0_TETTS	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family. (703 aa)
	Q245B9_TETTS	UBX domain protein. (491 aa)
	Q247T1_TETTS	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (247 aa)
	W7XEU7_TETTS	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family. (654 aa)
	W7XIH1_TETTS	Ubiquitin-like Rad60 SUMO-like protein. (480 aa)
	Q22WA2_TETTS	Ubiquitin elongating factor core protein. (1181 aa)
	Q22Y58_TETTS	Ubiquitin fusion degradation protein. (304 aa)

Your Current Organism:

Tetrahymena thermophila

NCBI taxonomy Id: 312017
Other names: T. thermophila SB210, Tetrahymena thermophila SB210

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I7M018_TETTS	Q22WA2_TETTS	I7M018	Q22WA2	Ubiquitin-conjugating enzyme.	Ubiquitin elongating factor core protein.	0.543
I7M018_TETTS	Q22Y58_TETTS	I7M018	Q22Y58	Ubiquitin-conjugating enzyme.	Ubiquitin fusion degradation protein.	0.440
I7M018_TETTS	Q23K99_TETTS	I7M018	Q23K99	Ubiquitin-conjugating enzyme.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.499
I7M018_TETTS	Q23QU7_TETTS	I7M018	Q23QU7	Ubiquitin-conjugating enzyme.	Ubiquitin elongating factor core protein.	0.543
I7M018_TETTS	Q245B9_TETTS	I7M018	Q245B9	Ubiquitin-conjugating enzyme.	UBX domain protein.	0.488
I7M018_TETTS	Q247T1_TETTS	I7M018	Q247T1	Ubiquitin-conjugating enzyme.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.499
I7M3G1_TETTS	I7MLP7_TETTS	I7M3G1	I7MLP7	Heat shock protein HSP90.	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	0.940
I7M3G1_TETTS	Q22TE0_TETTS	I7M3G1	Q22TE0	Heat shock protein HSP90.	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	0.940
I7M3G1_TETTS	W7XEU7_TETTS	I7M3G1	W7XEU7	Heat shock protein HSP90.	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	0.940
I7MLE0_TETTS	Q22WA2_TETTS	I7MLE0	Q22WA2	OTU-like cysteine protease.	Ubiquitin elongating factor core protein.	0.949
I7MLE0_TETTS	Q22Y58_TETTS	I7MLE0	Q22Y58	OTU-like cysteine protease.	Ubiquitin fusion degradation protein.	0.996
I7MLE0_TETTS	Q23QU7_TETTS	I7MLE0	Q23QU7	OTU-like cysteine protease.	Ubiquitin elongating factor core protein.	0.949
I7MLE0_TETTS	Q245B9_TETTS	I7MLE0	Q245B9	OTU-like cysteine protease.	UBX domain protein.	0.421
I7MLP7_TETTS	I7M3G1_TETTS	I7MLP7	I7M3G1	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	Heat shock protein HSP90.	0.940
I7MLP7_TETTS	Q22TE0_TETTS	I7MLP7	Q22TE0	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	0.905
I7MLP7_TETTS	Q23K99_TETTS	I7MLP7	Q23K99	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.656
I7MLP7_TETTS	Q247T1_TETTS	I7MLP7	Q247T1	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.656
I7MLP7_TETTS	W7XEU7_TETTS	I7MLP7	W7XEU7	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	0.901
Q22TE0_TETTS	I7M3G1_TETTS	Q22TE0	I7M3G1	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	Heat shock protein HSP90.	0.940
Q22TE0_TETTS	I7MLP7_TETTS	Q22TE0	I7MLP7	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	Heat shock-binding protein 70, ER luminal protein; Belongs to the heat shock protein 70 family.	0.905