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| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (288 aa) |
| | EAR24246.1 | Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (201 aa) |
| | EAR24319.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (301 aa) |
| | EAR24320.1 | Hypothetical protein; COG1985 Pyrimidine reductase, riboflavin biosynthesis. (255 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (468 aa) |
| | EAR24332.1 | COG0516 IMP dehydrogenase/GMP reductase. (478 aa) |
| | EAR25136.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (335 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (311 aa) |
| | EAR25138.1 | Putative integral membrane protein. (122 aa) |
| | EAR25139.1 | Putative integral membrane protein; COG0477 Permeases of the major facilitator superfamily. (137 aa) |
| | EAR25140.1 | Riboflavin kinase/ FMN adenyltransferase; COG0196 FAD synthase; Belongs to the ribF family. (318 aa) |
| | rbsK | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (304 aa) |
| | hisC | COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (362 aa) |
| | hisB | COG0131 Imidazoleglycerol-phosphate dehydratase. (201 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (210 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (249 aa) |
| | EAR25255.1 | COG0287 Prephenate dehydrogenase. (360 aa) |
| | EAR25338.1 | 2-dehydro-3-deoxyphosphoheptonate aldolase; COG3200 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the class-II DAHP synthase family. (456 aa) |
| | EAR24041.1 | Flavin-dependent reductase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. (167 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa) |
| | nrdR | Hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes. (98 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (344 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (351 aa) |
| | EAR24078.1 | Hypothetical protein; Belongs to the UPF0303 family. (160 aa) |
| | EAR24079.1 | Hypothetical protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family. (154 aa) |
| | EAR24080.1 | Short chain dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (258 aa) |
| | EAR24081.1 | Hypothetical protein. (174 aa) |
| | EAR24082.1 | Putative secreted protein; COG0330 Membrane protease subunits, stomatin/prohibitin homologs. (304 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (205 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (260 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | EAR24398.1 | COG0134 Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (256 aa) |
| | EAR24399.1 | Mambrane protein. (76 aa) |
| | EAR24400.1 | Anthranilate synthase component I; COG0477 Permeases of the major facilitator superfamily. (189 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (508 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (125 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (274 aa) |
| | hisE | COG0140 Phosphoribosyl-ATP pyrophosphohydrolase. (87 aa) |
| | EAR24406.1 | COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1. (124 aa) |
| | EAR24407.1 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa) |
| | EAR24408.1 | Putative RNA-binding Sun protein; COG0144 tRNA and rRNA cytosine-C5-methylases; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (454 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (309 aa) |
| | EAR24412.1 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (399 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (309 aa) |
| | EAR24415.1 | COG0284 Orotidine-5'-phosphate decarboxylase. (280 aa) |
| | carB | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (1104 aa) |
| | carA | COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (379 aa) |
| | EAR24418.1 | Probable export or membrane protein. (164 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (438 aa) |
| | pyrB | COG0540 Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (315 aa) |
| | pyrR | Pyrimidine regulatory protein PyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (175 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (359 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (169 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (401 aa) |
| | EAR24431.1 | COG0169 Shikimate 5-dehydrogenase. (285 aa) |
| | mltG | Hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (449 aa) |
| | EAR24433.1 | Hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (153 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (884 aa) |
| | EAR24435.1 | Hypothetical protein. (75 aa) |
| | EAR24436.1 | Secreted protein. (120 aa) |
| | EAR24438.1 | COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase. (472 aa) |
| | EAR24441.1 | Hypothetical protein. (190 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (154 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (276 aa) |
| | EAR25398.1 | Deoxyguanosinetriphosphate triphosphohydrolase-like protein; COG0232 dGTP triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily. (382 aa) |
| | EAR25440.1 | COG0147 Anthranilate/para-aminobenzoate synthases component I. (454 aa) |
| | EAR25487.1 | COG0105 Nucleoside diphosphate kinase. (138 aa) |
| | EAR25489.1 | COG0285 Folylpolyglutamate synthase. (507 aa) |
| | EAR25520.1 | Hypothetical protein; COG0457 FOG: TPR repeat. (162 aa) |
| | EAR25521.1 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. (318 aa) |
| | EAR25585.1 | Hypothetical protein. (170 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (162 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (167 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (372 aa) |
| | EAR24845.1 | COG1957 Inosine-uridine nucleoside N-ribohydrolase. (343 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa) |
| | purU | Formyletrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa) |
| | purH | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). (533 aa) |
| | purN | 5'-phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (194 aa) |
| | guaA | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. (533 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (199 aa) |
| | lysS | lysyl-tRNA synthetase. (62 aa) |
| | EAR25796.1 | Hypothetical protein. (29 aa) |
| | EAR25797.1 | Hypothetical protein. (41 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (287 aa) |
| | EAR25800.1 | Hypothetical protein. (249 aa) |
| | EAR25801.1 | COG3428 Predicted membrane protein. (555 aa) |
| | EAR25802.1 | Hypothetical protein. (161 aa) |
| | EAR25803.1 | Hypothetical protein. (162 aa) |
| | EAR25804.1 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (176 aa) |
| | EAR25805.1 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (140 aa) |
| | EAR25806.1 | COG0294 Dihydropteroate synthase and related enzymes. (262 aa) |
| | folE | COG0302 GTP cyclohydrolase I. (194 aa) |
| | ftsH | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (667 aa) |
| | EAR25810.1 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa) |
| | tilS | Hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (340 aa) |
| | EAR25844.1 | Probable 5'-nucleotidase precursor; COG2374 Predicted extracellular nuclease. (1422 aa) |
| | purM | COG0150 Phosphoribosylaminoimidazole (AIR) synthetase. (368 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (485 aa) |
| | purD | COG0151 Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (418 aa) |
| | purC | COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (301 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (90 aa) |
| | purQ | Phosphoribosyl formylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (232 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (769 aa) |
| | EAR25942.1 | COG1605 Chorismate mutase. (128 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (183 aa) |
| | aroE | COG0169 Shikimate 5-dehydrogenase. (270 aa) |
| | EAR25992.1 | COG0044 Dihydroorotase and related cyclic amidohydrolases. (470 aa) |
| | EAR26023.1 | Deoxycytidine triphosphate deaminase. (219 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (201 aa) |
| | EAR26025.1 | Riboflavin biosynthesis protein RibF (riboflavin kinase); COG0196 FAD synthase. (147 aa) |
| | EAR26026.1 | Putative oxidoreductase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. (164 aa) |
| | EAR26027.1 | Hypothetical protein; COG1695 Predicted transcriptional regulators. (199 aa) |
| | EAR26133.1 | Putative aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (361 aa) |
| | EAR26138.1 | COG0015 Adenylosuccinate lyase. (463 aa) |
| | EAR26172.1 | COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid). (214 aa) |
| | EAR26176.1 | COG0512 Anthranilate/para-aminobenzoate synthases component II. (211 aa) |
| | EAR23963.1 | COG0077 Prephenate dehydratase. (334 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (421 aa) |
| | EAR23966.1 | Hypothetical protein; COG0561 Predicted hydrolases of the HAD superfamily. (271 aa) |
| | EAR24603.1 | Putative secreted or membrane protein; COG2268 Uncharacterized protein conserved in bacteria. (484 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa) |
| | EAR24143.1 | COG1435 Thymidine kinase. (221 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (209 aa) |
| | ribH | Riboflavin synthase subunit beta; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (157 aa) |
| | ribA | 3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family. (430 aa) |
| | EAR24172.1 | COG0307 Riboflavin synthase alpha chain. (207 aa) |
| | EAR24173.1 | Riboflavin-specific deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (345 aa) |
| | EAR24174.1 | COG1011 Predicted hydrolase (HAD superfamily). (242 aa) |
| | EAR24175.1 | COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins. (188 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (336 aa) |
| | EAR24178.1 | Narrowly hypothetical protein; COG1295 Predicted membrane protein. (355 aa) |
| | EAR24187.1 | Surface lipoprotein; COG1744 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein. (381 aa) |
| | EAR24188.1 | ABC transporter, ATP-binding protein; COG3845 ABC-type uncharacterized transport systems, ATPase components. (504 aa) |
| | EAR24189.1 | COG4603 ABC-type uncharacterized transport system, permease component; Belongs to the binding-protein-dependent transport system permease family. (418 aa) |
| | EAR24190.1 | COG4603 ABC-type uncharacterized transport system, permease component; Belongs to the binding-protein-dependent transport system permease family. (426 aa) |
| | EAR24191.1 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (138 aa) |
| | EAR24192.1 | COG0213 Thymidine phosphorylase. (438 aa) |
| | EAR24194.1 | IunH; COG1957 Inosine-uridine nucleoside N-ribohydrolase. (315 aa) |
| | EAR24197.1 | COG1816 Adenosine deaminase. (373 aa) |
| | EAR24200.1 | COG1109 Phosphomannomutase. (550 aa) |
| | EAR24201.1 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (281 aa) |
| | EAR24216.1 | Ribonucleotide-diphosphate reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (813 aa) |
| | EAR24218.1 | Ribonucleotide-diphosphate reductase beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (332 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (385 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (974 aa) |
| | EAR23842.1 | Putative amino transferase; COG0518 GMP synthase - Glutamine amidotransferase domain. (235 aa) |
