node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VF_A0954 | hcp | VF_A0954 | VF_A0863 | Hemolysin co-regulated protein. | Hydroxylamine reductase Hcp; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | 0.475 |
VF_A0954 | icmF | VF_A0954 | VF_0993 | Hemolysin co-regulated protein. | Secretion protein IcmF. | 0.919 |
VF_A0954 | luxO | VF_A0954 | VF_0937 | Hemolysin co-regulated protein. | Autoinducer repressor protein LuxO. | 0.497 |
VF_A0954 | luxS | VF_A0954 | VF_0545 | Hemolysin co-regulated protein. | S-ribosylhomocysteinase, autoinducer-2 synthase protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.440 |
djlA | dnaJ | VF_0290 | VF_1993 | DnaJ-like protein, membrane anchored; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | Chaperone Hsp40/DnaJ, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...] | 0.651 |
djlA | galE | VF_0290 | VF_A0352 | DnaJ-like protein, membrane anchored; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | UDP-galactose-4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | 0.444 |
djlA | icmF | VF_0290 | VF_0993 | DnaJ-like protein, membrane anchored; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | Secretion protein IcmF. | 0.451 |
djlA | pilP | VF_0290 | VF_2294 | DnaJ-like protein, membrane anchored; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | Pili assembly protein PilP. | 0.441 |
dnaJ | djlA | VF_1993 | VF_0290 | Chaperone Hsp40/DnaJ, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...] | DnaJ-like protein, membrane anchored; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | 0.651 |
dnaJ | rscS | VF_1993 | VF_A0237 | Chaperone Hsp40/DnaJ, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...] | Hybrid sensor kinase RscS; Activator of syp locus genes. | 0.459 |
dnaJ | sypE | VF_1993 | VF_A1024 | Chaperone Hsp40/DnaJ, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...] | Two-component response regulator, sigma factor PP2C-like phosphatase; Syp polysaccharide locus. | 0.447 |
galE | djlA | VF_A0352 | VF_0290 | UDP-galactose-4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | DnaJ-like protein, membrane anchored; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | 0.444 |
galE | galU | VF_A0352 | VF_0342 | UDP-galactose-4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | Glucose-1-phosphate uridylyltransferase. | 0.968 |
galU | galE | VF_0342 | VF_A0352 | Glucose-1-phosphate uridylyltransferase. | UDP-galactose-4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | 0.968 |
galU | rscS | VF_0342 | VF_A0237 | Glucose-1-phosphate uridylyltransferase. | Hybrid sensor kinase RscS; Activator of syp locus genes. | 0.404 |
hcp | VF_A0954 | VF_A0863 | VF_A0954 | Hydroxylamine reductase Hcp; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Hemolysin co-regulated protein. | 0.475 |
hcp | icmF | VF_A0863 | VF_0993 | Hydroxylamine reductase Hcp; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Secretion protein IcmF. | 0.558 |
hcp | ompU | VF_A0863 | VF_0475 | Hydroxylamine reductase Hcp; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. | Outer membrane protein U porin OmpU. | 0.443 |
icmF | VF_A0954 | VF_0993 | VF_A0954 | Secretion protein IcmF. | Hemolysin co-regulated protein. | 0.919 |
icmF | djlA | VF_0993 | VF_0290 | Secretion protein IcmF. | DnaJ-like protein, membrane anchored; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. | 0.451 |