STRINGSTRING
dnaA dnaA ntrC ntrC ntrB ntrB glnA glnA ompR ompR envZ envZ gfcE gfcE etp etp wzc wzc rpoN rpoN yneH yneH phoQ2 phoQ2 phoQ1 phoQ1 phoP phoP csrA csrA luxP luxP luxQ luxQ motA1 motA1 VfcA VfcA luxO luxO luxU luxU cydA cydA cydB cydB ybgT ybgT VF_0987 VF_0987 ainR ainR VF_1054 VF_1054 VF_1088 VF_1088 VF_1091 VF_1091 VF_1133 VF_1133 ccoN ccoN ccoO ccoO ccoQ ccoQ ccoP ccoP VF_1369 VF_1369 VF_1503 VF_1503 maeA maeA torR torR torD torD pstS2 pstS2 VF_1618 VF_1618 torS torS gacA gacA VF_1778 VF_1778 VF_1789 VF_1789 cheW cheW VF_1828 VF_1828 cheB cheB cheA cheA cheY cheY fliA fliA flrC flrC flrB flrB flrA flrA flaE flaE flaD flaD flaC flaC flaB flaB flaA flaA cheR cheR cheV1 cheV1 flgM flgM narQ narQ narP narP glnB glnB glnD glnD pstS pstS phoR phoR phoB phoB VF_2042 VF_2042 dcuB dcuB flaF flaF gacS gacS arcA arcA arcB arcB VF_2161 VF_2161 litR litR pilA pilA VF_2217 VF_2217 VF_2218 VF_2218 VF_2220 VF_2220 degP degP tolC tolC VF_2236 VF_2236 crp crp frdA frdA frdB frdB frdC frdC frdD frdD cpxR cpxR cpxA cpxA uhpC uhpC uhpB uhpB uhpA uhpA uhpT uhpT VF_A0092 VF_A0092 VF_A0102 VF_A0102 VF_A0103 VF_A0103 VF_A0107 VF_A0107 VF_A0169 VF_A0169 VF_A0170 VF_A0170 cusS cusS cusR cusR motA2 motA2 torC torC torA torA VF_A0325 VF_A0325 VF_A0389 VF_A0389 cusB cusB cusA cusA VF_A0447 VF_A0447 VF_A0448 VF_A0448 VF_A0528 VF_A0528 VF_A0555 VF_A0555 VF_A0677 VF_A0677 cheV3 cheV3 cheV2 cheV2 luxE luxE luxB luxB luxA luxA luxD luxD luxC luxC sypG sypG VF_A1069 VF_A1069 VF_A1071 VF_A1071 VF_A1072 VF_A1072 VF_A1084 VF_A1084
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (469 aa)
ntrCDNA-binding transcriptional regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (467 aa)
ntrBNitrogen regulatory sensory histidine kinase in two-component regulatory system with NtrC. (352 aa)
glnAGlutamine synthetase. (469 aa)
ompROmpR DNA-binding osmolarity response regulator in two-component regulatory system with EnvZ. (239 aa)
envZEnvZ osmolarity sensory histidine kinase in two-component regulatory system with OmpR. (434 aa)
gfcEPredicted exopolysaccharide export protein. (383 aa)
etpPhosphotyrosine-protein phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (146 aa)
wzcProtein-tyrosine kinase, chain length regulator in capsular polysaccharide biosynthesis. (720 aa)
rpoNRNA polymerase, sigma 54 (sigma N) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (489 aa)
yneHPredicted glutaminase; Belongs to the glutaminase family. (306 aa)
phoQ2Sensory histidine kinase in two-compoent regulatory system with PhoP. (320 aa)
phoQ1Sensory histidine kinase in two-compoent regulatory system with PhoP. (447 aa)
phoPDNA-binding response regulator in two-component regulatory system with PhoQ. (226 aa)
csrAPleiotropic regulatory protein for carbon source metabolism; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small [...] (65 aa)
luxPPeriplasmic AI-2 binding protein LuxP. (372 aa)
luxQMembrane-bound sensor histidine kinase LuxQ. (744 aa)
motA1Flagellar motor protein MotA1. (254 aa)
VfcAMethyl-accepting chemotaxis protein. (624 aa)
luxOAutoinducer repressor protein LuxO. (476 aa)
luxUAutoinducer phosphorelay protein LuxU. (118 aa)
cydACytochrome d terminal oxidase, subunit I. (529 aa)
cydBCytochrome d terminal oxidase, subunit II. (378 aa)
ybgTCyd operon protein YbgT. (35 aa)
VF_0987Methyl-accepting chemotaxis protein. (650 aa)
ainRPutative autoinducer regulatory protein AinR. (819 aa)
VF_1054ScrF protein. (157 aa)
VF_1088Anaerobic C4-dicarboxylate transporter; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family. (437 aa)
VF_1091Methyl-accepting chemotaxis protein. (524 aa)
VF_1133Methyl-accepting chemotaxis protein. (669 aa)
ccoNCytochrome c oxidase, cbb3-type, subunit I; Belongs to the heme-copper respiratory oxidase family. (476 aa)
ccoOCytochrome c oxidase, cbb3-type, subunit II. (203 aa)
ccoQCbb3-type cytochrome oxidase component FixQ family. (61 aa)
ccoPCytochrome c oxidase, cbb3-type, subunit III; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. (323 aa)
VF_1369Methyl-accepting chemotaxis protein. (677 aa)
VF_1503Methyl-accepting chemotaxis protein. (467 aa)
maeAMalate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme); Belongs to the malic enzymes family. (562 aa)
torRDNA-binding response regulator in two-component regulatory system with TorS. (232 aa)
torDChaperone involved in maturation of TorA subunit of trimethylamine N-oxide reductase system I; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily. (215 aa)
pstS2Phosphate-binding protein. (273 aa)
VF_1618Methyl-accepting chemotaxis protein. (546 aa)
torSHybrid sensory histidine kinase in two-component regulatory system with TorR. (972 aa)
gacADNA-binding response regulator in two-component regulatory system with GacS. (214 aa)
VF_1778Methyl-accepting chemotaxis protein. (539 aa)
VF_1789Methyl-accepting chemotaxis protein. (697 aa)
cheWChemotaxis coupling protein CheW. (164 aa)
VF_1828C-terminal CheW domain, putative chemotaxis coupling protein. (352 aa)
cheBChemotaxis response regulator protein-glutamate methylesterase CheB; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (376 aa)
cheAChemotactic sensory histidine kinase CheA, in two-component regulatory system with CheB and CheY. (735 aa)
cheYChemotaxis regulator CheY, transmits signal to flagellar motor component. (122 aa)
fliARNA polymerase, sigma-28 (sigma-F, FliA) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (243 aa)
flrCTwo-component response regulator FlrC. (477 aa)
flrBSensory histidine kinase FlrB. (353 aa)
flrASigma-54-dependent transcriptional activator FlrA. (493 aa)
flaEFlagellin FlaE; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (398 aa)
flaDFlagellin FlaD; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (375 aa)
flaCFlagellin FlaC; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (377 aa)
flaBFlagellin FlaB; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (377 aa)
flaAFlagellin FlaA; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (379 aa)
cheRChemotaxis regulator, protein-glutamate methyltransferase, CheR. (275 aa)
cheV1CheW/CheY hybrid protein CheV1. (306 aa)
flgMFlagellar anti-sigma-28 factor FlgM. (103 aa)
narQSensory histidine kinase in two-component regulatory system with NarP (NarL). (563 aa)
narPDNA-binding response regulator in two-component regulatory system with NarQ. (203 aa)
glnBRegulatory protein P-II for glutamine synthetase. (112 aa)
glnDUridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (873 aa)
pstSPhosphate-binding protein. (329 aa)
phoRSensory histidine kinase in two-component regulatory system with PhoB. (431 aa)
phoBDNA-binding response regulator in two-component regulatory system with PhoR. (230 aa)
VF_2042Methyl-accepting chemotaxis protein. (542 aa)
dcuBC4-dicarboxylate antiporter; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family. (410 aa)
flaFFlagellin FlaF; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (377 aa)
gacSHybrid sensory histidine kinase, in two-component regulatory system with GacA. (931 aa)
arcADNA-binding response regulator in two-component regulatory system with ArcB or CpxA. (239 aa)
arcBHybrid sensory histidine kinase in two-component regulatory system with ArcA. (788 aa)
VF_2161Methyl-accepting chemotaxis protein. (498 aa)
litRQuorum sensing transcriptional regulator LitR (HapR). (201 aa)
pilAPilin subunit PilA; Belongs to the N-Me-Phe pilin family. (134 aa)
VF_2217Cytochrome c1. (245 aa)
VF_2218Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (422 aa)
VF_2220Ubiquinol-cytochrome c reductase iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (197 aa)
degPSerine endoprotease DegP (protease Do), periplasmic; Belongs to the peptidase S1C family. (455 aa)
tolCTransport channel. (441 aa)
VF_2236Methyl-accepting chemotaxis protein. (533 aa)
crpDNA-binding transcriptional regulator CRP. (210 aa)
frdAFumarate reductase (anaerobic) catalytic and NAD/flavoprotein subunit. (601 aa)
frdBFumarate reductase (anaerobic), Fe-S subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (247 aa)
frdCFumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (127 aa)
frdDFumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (140 aa)
cpxRDNA-binding response regulator in two-component regulatory system with CpxA. (227 aa)
cpxASensory histidine kinase in two-component regulatory system with CpxR. (462 aa)
uhpCMembrane protein regulates uhpT expression. (446 aa)
uhpBSensory histidine kinase in two-component regulatory sytem with UhpA. (485 aa)
uhpADNA-binding response regulator in two-component regulatory system wtih UhpB. (202 aa)
uhpTHexose phosphate transporter. (464 aa)
VF_A0092Methyl-accepting chemotaxis protein, putative aerotaxis receptor. (518 aa)
VF_A0102Two component sensor histidine kinase. (565 aa)
VF_A0103Two component response regulator. (205 aa)
VF_A0107Methyl-accepting chemotaxis protein. (606 aa)
VF_A0169Methyl-accepting chemotaxis protein. (543 aa)
VF_A0170Methyl-accepting chemotaxis protein. (541 aa)
cusSSensory histidine kinase in two-component regulatory system with CusR, senses copper ions; Member of a two-component regulatory system. (446 aa)
cusRDNA-binding response regulator in two-component regulatory system with CusS. (226 aa)
motA2Flagellar motor protein MotA2. (260 aa)
torCTrimethylamine N-oxide reductase, cytochrome c-type subunit; Belongs to the TorC/TorY family. (392 aa)
torATrimethylamine N-oxide (TMAO) reductase I, catalytic subunit. (952 aa)
VF_A0325Methyl-accepting chemotaxis protein. (561 aa)
VF_A0389Methyl-accepting chemotaxis protein. (621 aa)
cusBCopper/silver efflux system, membrane fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (489 aa)
cusACopper/silver efflux system, membrane component; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1039 aa)
VF_A0447Methyl-accepting chemotaxis protein. (542 aa)
VF_A0448Methyl-accepting chemotaxis protein. (542 aa)
VF_A0528Methyl-accepting chemotaxis protein. (547 aa)
VF_A0555Phosphate-binding protein. (270 aa)
VF_A0677Methyl-accepting chemotaxis protein. (637 aa)
cheV3CheW/CheY hybrid protein CheV3. (298 aa)
cheV2CheW/CheY hybrid protein CheV2. (313 aa)
luxELong-chain-fatty-acid ligase LuxE. (376 aa)
luxBLuciferase beta chain LuxB. (326 aa)
luxALuciferase alpha chain LuxA. (355 aa)
luxDAcyl transferase LuxD; Acyl transferase is part of the fatty acid reductase system required for aldehyde biosynthesis; it produces fatty acids for the luminescent reaction; Belongs to the LuxD family. (307 aa)
luxCacyl-CoA reductase LuxC; LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase. (479 aa)
sypGSigma-54 dependent transcriptional regulator; Syp polysaccharide locus. (500 aa)
VF_A1069Methyl-accepting chemotaxis protein. (531 aa)
VF_A1071Methyl-accepting chemotaxis protein, putative aerotaxis receptor. (509 aa)
VF_A1072Methyl-accepting chemotaxis protein. (524 aa)
VF_A1084Methyl-accepting chemotaxis protein. (624 aa)
Your Current Organism:
Aliivibrio fischeri
NCBI taxonomy Id: 312309
Other names: A. fischeri ES114, Aliivibrio fischeri ES114, Vibrio fischeri ES114, Vibrio fischeri str. ES114, Vibrio fischeri strain ES114
Server load: low (22%) [HD]