(84 nodes) Mixed, incl. Small GTPase mediated signal transduction, and ErbB signaling pathway network (Caenorhabditis remanei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cre-pak-1	Non-specific serine/threonine protein kinase. (570 aa)
	Cre-nck-1	CRE-NCK-1 protein. (392 aa)
	Cre-max-2	Non-specific serine/threonine protein kinase. (637 aa)
	Cre-age-1	CRE-AGE-1 protein; Belongs to the PI3/PI4-kinase family. (1188 aa)
	CRE_02136	Rho-GAP domain-containing protein. (165 aa)
	Cre-rga-1	CRE-RGA-1 protein. (248 aa)
	Cre-tag-341	CRE-TAG-341 protein. (788 aa)
	CRE_18937	Uncharacterized protein. (221 aa)
	Cre-pes-7	CRE-PES-7 protein. (1442 aa)
	CRE_28372	Tyrosine-protein kinase. (616 aa)
	Cre-ksr-2	CRE-KSR-2 protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (549 aa)
	Cre-cdc-42	CRE-CDC-42 protein. (191 aa)
	Cre-akt-1	Non-specific serine/threonine protein kinase. (612 aa)
	CRE_29471	Uncharacterized protein. (221 aa)
	Cre-tag-163	CRE-TAG-163 protein. (666 aa)
	Cre-src-1	Tyrosine-protein kinase. (525 aa)
	Cre-cnk-1	CRE-CNK-1 protein. (801 aa)
	Cre-rol-3	CRE-ROL-3 protein. (1333 aa)
	CRE_05707	Uncharacterized protein. (1163 aa)
	Cre-ras-1	CRE-RAS-1 protein. (211 aa)
	Cre-mig-2	CRE-MIG-2 protein. (195 aa)
	Cre-ssr-2	CRE-SSR-2 protein. (325 aa)
	Cre-git-1	CRE-GIT-1 protein. (670 aa)
	Cre-csk-1	CRE-CSK-1 protein. (1418 aa)
	Cre-hum-7	CRE-HUM-7 protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1887 aa)
	CRE_11036	Uncharacterized protein. (401 aa)
	Cre-ced-5	CRE-CED-5 protein; Belongs to the DOCK family. (1783 aa)
	Cre-let-60	CRE-LET-60 protein. (184 aa)
	Cre-srgp-1	CRE-SRGP-1 protein. (1059 aa)
	CRE_13931	Uncharacterized protein. (465 aa)
	CRE_17067	Uncharacterized protein. (430 aa)
	Cre-pdk-1	CRE-PDK-1 protein. (629 aa)
	Cre-vav-1	CRE-VAV-1 protein. (1020 aa)
	Cre-tag-325	CRE-TAG-325 protein. (842 aa)
	Cre-ras-2	CRE-RAS-2 protein. (211 aa)
	Cre-pix-1	CRE-PIX-1 protein. (643 aa)
	Cre-src-2	Tyrosine-protein kinase. (527 aa)
	CRE_23953	Uncharacterized protein. (355 aa)
	CRE_23954	DH domain-containing protein. (576 aa)
	Cre-ced-12	CRE-CED-12 protein. (732 aa)
	CRE_24005	Uncharacterized protein. (1571 aa)
	CRE_24006	Uncharacterized protein. (479 aa)
	CRE_24008	Uncharacterized protein. (809 aa)
	CRE_24009	Uncharacterized protein. (465 aa)
	Cre-unc-73	CRE-UNC-73 protein. (2483 aa)
	Cre-ksr-1	CRE-KSR-1 protein. (767 aa)
	CRE_25661	Uncharacterized protein. (864 aa)
	Cre-pxf-1	CRE-PXF-1 protein. (1476 aa)
	CRE_29931	Uncharacterized protein. (224 aa)
	Cre-rrc-1	CRE-RRC-1 protein. (795 aa)
	CRE_12055	Uncharacterized protein. (74 aa)
	Cre-chw-1	CRE-CHW-1 protein. (207 aa)
	CRE_13532	Uncharacterized protein. (559 aa)
	CRE_14062	Rho-GAP domain-containing protein. (1119 aa)
	CRE_18095	Protein kinase domain-containing protein. (309 aa)
	Cre-aap-1	CRE-AAP-1 protein. (576 aa)
	CRE_30054	Uncharacterized protein. (155 aa)
	Cre-mek-2	CRE-MEK-2 protein. (246 aa)
	CRE_24663	Uncharacterized protein. (807 aa)
	CRE_09743	Uncharacterized protein. (371 aa)
	Cre-rap-1	CRE-RAP-1 protein. (188 aa)
	Cre-pak-2	CRE-PAK-2 protein. (260 aa)
	Cre-trk-1	CRE-TRK-1 protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (834 aa)
	CRE_06983	Uncharacterized protein. (750 aa)
	CRE_06991	Uncharacterized protein. (496 aa)
	CRE_06976	B box-type domain-containing protein. (272 aa)
	Cre-rap-2	CRE-RAP-2 protein. (181 aa)
	CRE_11480	Uncharacterized protein. (501 aa)
	CRE_13739	Rho-GAP domain-containing protein. (87 aa)
	CRE_19483	RING-type domain-containing protein. (324 aa)
	CRE_20984	Uncharacterized protein. (367 aa)
	CRE_24266	RING-type domain-containing protein. (1171 aa)
	CRE_24267	Uncharacterized protein. (792 aa)
	Cre-rgef-1	CRE-RGEF-1 protein. (460 aa)
	CRE_15027	Uncharacterized protein; Belongs to the DOCK family. (544 aa)
	CRE_29240	Uncharacterized protein. (151 aa)
	CRE_21603	Uncharacterized protein. (232 aa)
	CRE_16535	DHR-2 domain-containing protein; Belongs to the DOCK family. (301 aa)
	CRE_18332	Uncharacterized protein. (233 aa)
	CRE_23245	PX domain-containing protein. (135 aa)
	CRE_14414	Rho-GAP domain-containing protein. (1114 aa)
	CRE_24347	Uncharacterized protein; Belongs to the protein kinase superfamily. (496 aa)
	CRE_18375	Uncharacterized protein. (180 aa)
	CRE_19646	Uncharacterized protein. (181 aa)

Your Current Organism:

Caenorhabditis remanei

NCBI taxonomy Id: 31234
Other names: C. remanei, Caenorhabditis vulgaris

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRE_02136	CRE_06976	E3LF87	E3NB38	Rho-GAP domain-containing protein.	B box-type domain-containing protein.	0.747
CRE_02136	CRE_06983	E3LF87	E3NB11	Rho-GAP domain-containing protein.	Uncharacterized protein.	0.747
CRE_02136	CRE_06991	E3LF87	E3NB34	Rho-GAP domain-containing protein.	Uncharacterized protein.	0.747
CRE_02136	CRE_11480	E3LF87	E3NEQ7	Rho-GAP domain-containing protein.	Uncharacterized protein.	0.747
CRE_02136	CRE_13739	E3LF87	E3NEW9	Rho-GAP domain-containing protein.	Rho-GAP domain-containing protein.	0.632
CRE_02136	CRE_13931	E3LF87	E3M8U3	Rho-GAP domain-containing protein.	Uncharacterized protein.	0.747
CRE_02136	CRE_14062	E3LF87	E3MRB7	Rho-GAP domain-containing protein.	Rho-GAP domain-containing protein.	0.632
CRE_02136	CRE_14414	E3LF87	E3NRE6	Rho-GAP domain-containing protein.	Rho-GAP domain-containing protein.	0.632
CRE_02136	CRE_18095	E3LF87	E3MTZ8	Rho-GAP domain-containing protein.	Protein kinase domain-containing protein.	0.703
CRE_02136	CRE_19483	E3LF87	E3NG60	Rho-GAP domain-containing protein.	RING-type domain-containing protein.	0.747
CRE_02136	CRE_19646	E3LF87	E3NWX8	Rho-GAP domain-containing protein.	Uncharacterized protein.	0.747
CRE_02136	CRE_20984	E3LF87	E3NHM7	Rho-GAP domain-containing protein.	Uncharacterized protein.	0.747
CRE_02136	CRE_24266	E3LF87	E3NHQ0	Rho-GAP domain-containing protein.	RING-type domain-containing protein.	0.747
CRE_02136	CRE_24267	E3LF87	E3NHQ1	Rho-GAP domain-containing protein.	Uncharacterized protein.	0.747
CRE_02136	CRE_29471	E3LF87	E3LV66	Rho-GAP domain-containing protein.	Uncharacterized protein.	0.747
CRE_02136	Cre-aap-1	E3LF87	E3MX87	Rho-GAP domain-containing protein.	CRE-AAP-1 protein.	0.613
CRE_02136	Cre-cdc-42	E3LF87	E3LRQ6	Rho-GAP domain-containing protein.	CRE-CDC-42 protein.	0.829
CRE_02136	Cre-chw-1	E3LF87	E3MQS5	Rho-GAP domain-containing protein.	CRE-CHW-1 protein.	0.829
CRE_02136	Cre-git-1	E3LF87	E3M2Z2	Rho-GAP domain-containing protein.	CRE-GIT-1 protein.	0.667
CRE_02136	Cre-hum-7	E3LF87	E3M3L8	Rho-GAP domain-containing protein.	CRE-HUM-7 protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.892