(22 nodes) RAC1 GTPase cycle, and Cdc42 protein signal transduction network (Caenorhabditis remanei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cre-pak-1	Non-specific serine/threonine protein kinase. (570 aa)
	Cre-nck-1	CRE-NCK-1 protein. (392 aa)
	Cre-max-2	Non-specific serine/threonine protein kinase. (637 aa)
	CRE_02136	Rho-GAP domain-containing protein. (165 aa)
	Cre-rga-1	CRE-RGA-1 protein. (248 aa)
	Cre-tag-341	CRE-TAG-341 protein. (788 aa)
	Cre-pes-7	CRE-PES-7 protein. (1442 aa)
	Cre-cdc-42	CRE-CDC-42 protein. (191 aa)
	Cre-mig-2	CRE-MIG-2 protein. (195 aa)
	Cre-git-1	CRE-GIT-1 protein. (670 aa)
	Cre-hum-7	CRE-HUM-7 protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1887 aa)
	CRE_13931	Uncharacterized protein. (465 aa)
	Cre-tag-325	CRE-TAG-325 protein. (842 aa)
	Cre-pix-1	CRE-PIX-1 protein. (643 aa)
	CRE_23954	DH domain-containing protein. (576 aa)
	Cre-unc-73	CRE-UNC-73 protein. (2483 aa)
	Cre-chw-1	CRE-CHW-1 protein. (207 aa)
	CRE_18095	Protein kinase domain-containing protein. (309 aa)
	Cre-pak-2	CRE-PAK-2 protein. (260 aa)
	Cre-rap-2	CRE-RAP-2 protein. (181 aa)
	Cre-rgef-1	CRE-RGEF-1 protein. (460 aa)
	CRE_19646	Uncharacterized protein. (181 aa)

Your Current Organism:

Caenorhabditis remanei

NCBI taxonomy Id: 31234
Other names: C. remanei, Caenorhabditis vulgaris

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRE_02136	CRE_13931	E3LF87	E3M8U3	Rho-GAP domain-containing protein.	Uncharacterized protein.	0.747
CRE_02136	CRE_18095	E3LF87	E3MTZ8	Rho-GAP domain-containing protein.	Protein kinase domain-containing protein.	0.703
CRE_02136	CRE_19646	E3LF87	E3NWX8	Rho-GAP domain-containing protein.	Uncharacterized protein.	0.747
CRE_02136	Cre-cdc-42	E3LF87	E3LRQ6	Rho-GAP domain-containing protein.	CRE-CDC-42 protein.	0.829
CRE_02136	Cre-chw-1	E3LF87	E3MQS5	Rho-GAP domain-containing protein.	CRE-CHW-1 protein.	0.829
CRE_02136	Cre-git-1	E3LF87	E3M2Z2	Rho-GAP domain-containing protein.	CRE-GIT-1 protein.	0.667
CRE_02136	Cre-hum-7	E3LF87	E3M3L8	Rho-GAP domain-containing protein.	CRE-HUM-7 protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.892
CRE_02136	Cre-max-2	E3LF87	E3LEZ4	Rho-GAP domain-containing protein.	Non-specific serine/threonine protein kinase.	0.703
CRE_02136	Cre-mig-2	E3LF87	E3M255	Rho-GAP domain-containing protein.	CRE-MIG-2 protein.	0.829
CRE_02136	Cre-pak-1	E3LF87	E3LDR3	Rho-GAP domain-containing protein.	Non-specific serine/threonine protein kinase.	0.703
CRE_02136	Cre-pak-2	E3LF87	E3N768	Rho-GAP domain-containing protein.	CRE-PAK-2 protein.	0.703
CRE_02136	Cre-pes-7	E3LF87	E3LLR7	Rho-GAP domain-containing protein.	CRE-PES-7 protein.	0.699
CRE_02136	Cre-pix-1	E3LF87	E3ME30	Rho-GAP domain-containing protein.	CRE-PIX-1 protein.	0.702
CRE_02136	Cre-rap-2	E3LF87	E3NCJ0	Rho-GAP domain-containing protein.	CRE-RAP-2 protein.	0.747
CRE_02136	Cre-rga-1	E3LF87	E3LF89	Rho-GAP domain-containing protein.	CRE-RGA-1 protein.	0.825
CRE_02136	Cre-tag-325	E3LF87	E3MCR8	Rho-GAP domain-containing protein.	CRE-TAG-325 protein.	0.754
CRE_02136	Cre-tag-341	E3LF87	E3LG87	Rho-GAP domain-containing protein.	CRE-TAG-341 protein.	0.632
CRE_13931	CRE_02136	E3M8U3	E3LF87	Uncharacterized protein.	Rho-GAP domain-containing protein.	0.747
CRE_13931	CRE_18095	E3M8U3	E3MTZ8	Uncharacterized protein.	Protein kinase domain-containing protein.	0.781
CRE_13931	CRE_23954	E3M8U3	E3MG45	Uncharacterized protein.	DH domain-containing protein.	0.740