(80 nodes) Mixed, incl. Clathrin coat, and Dynamin network (Caenorhabditis remanei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cre-dct-1	CRE-DCT-1 protein. (214 aa)
	Cre-tag-257	CRE-TAG-257 protein. (579 aa)
	Cre-aps-2	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	Cre-dpy-23	CRE-DPY-23 protein; Belongs to the adaptor complexes medium subunit family. (435 aa)
	CRE_02155	Uncharacterized protein. (319 aa)
	CRE_01610	RING-CH-type domain-containing protein. (186 aa)
	Cre-clic-1	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
	Cre-aps-3	CRE-APS-3 protein. (192 aa)
	CRE_28135	Uncharacterized protein. (564 aa)
	Cre-fis-1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (143 aa)
	Cre-vps-35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (840 aa)
	CRE_32629	Uncharacterized protein. (235 aa)
	Cre-apb-1	AP complex subunit beta. (814 aa)
	CRE_25197	B2-adapt-app_C domain-containing protein. (160 aa)
	Cre-chc-1	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1698 aa)
	Cre-vps-29	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (187 aa)
	CRE_25548	EH domain-containing protein. (370 aa)
	Cre-aps-1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (157 aa)
	Cre-apm-1	CRE-APM-1 protein; Belongs to the adaptor complexes medium subunit family. (443 aa)
	Cre-snx-3	CRE-SNX-3 protein. (177 aa)
	CRE_29833	Uncharacterized protein. (585 aa)
	Cre-unc-57	CRE-UNC-57 protein. (402 aa)
	Cre-pdr-1	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (387 aa)
	CRE_06419	DUF1681 domain-containing protein. (233 aa)
	CRE_06694	PX domain-containing protein. (478 aa)
	Cre-apd-3	AP-3 complex subunit delta; Belongs to the adaptor complexes large subunit family. (1235 aa)
	Cre-pink-1	CRE-PINK-1 protein. (638 aa)
	Cre-ehs-1	CRE-EHS-1 protein. (852 aa)
	Cre-fzo-1	CRE-FZO-1 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (804 aa)
	CRE_10249	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (650 aa)
	Cre-unc-26	CRE-UNC-26 protein. (1121 aa)
	CRE_10297	Uncharacterized protein. (604 aa)
	Cre-arf-1.1	CRE-ARF-1.1 protein; Belongs to the small GTPase superfamily. Arf family. (263 aa)
	CRE_13935	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (514 aa)
	Cre-snx-1	CRE-SNX-1 protein. (473 aa)
	Cre-apm-3	CRE-APM-3 protein; Belongs to the adaptor complexes medium subunit family. (434 aa)
	Cre-apa-2	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (940 aa)
	Cre-epn-1	CRE-EPN-1 protein. (525 aa)
	Cre-dyn-1	CRE-DYN-1 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (879 aa)
	Cre-sel-5	CRE-SEL-5 protein. (1081 aa)
	CRE_17946	Uncharacterized protein. (1008 aa)
	Cre-dnj-25	CRE-DNJ-25 protein. (685 aa)
	CRE_21171	J domain-containing protein. (107 aa)
	Cre-snx-6	CRE-SNX-6 protein. (477 aa)
	Cre-apg-1	AP-1 complex subunit gamma. (838 aa)
	Cre-pgam-5	CRE-PGAM-5 protein. (324 aa)
	Cre-fis-2	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (151 aa)
	Cre-itsn-1	CRE-ITSN-1 protein. (1121 aa)
	CRE_04077	Rab-GAP TBC domain-containing protein. (628 aa)
	Cre-drp-1	CRE-DRP-1 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (720 aa)
	CRE_13447	GED domain-containing protein. (269 aa)
	Cre-amph-1	CRE-AMPH-1 protein. (466 aa)
	Cre-rme-8	CRE-RME-8 protein. (2274 aa)
	CRE_24056	Uncharacterized protein. (158 aa)
	Cre-rsd-3	CRE-RSD-3 protein. (482 aa)
	Cre-reps-1	CRE-REPS-1 protein. (416 aa)
	Cre-unc-101	CRE-UNC-101 protein; Belongs to the adaptor complexes medium subunit family. (422 aa)
	Cre-eat-3	CRE-EAT-3 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (971 aa)
	Cre-vps-26	CRE-VPS-26 protein. (355 aa)
	CRE_08526	ENTH domain-containing protein. (443 aa)
	Cre-apb-3	CRE-APB-3 protein. (615 aa)
	Cre-hipr-1	CRE-HIPR-1 protein. (1061 aa)
	CRE_29048	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (810 aa)
	CRE_20055	Uncharacterized protein. (190 aa)
	CRE_27917	Adaptin_N domain-containing protein. (277 aa)
	CRE_03505	SH3 domain-containing protein. (132 aa)
	CRE_20604	Adaptin_N domain-containing protein. (166 aa)
	CRE_05280	Uncharacterized protein. (485 aa)
	CRE_05281	Uncharacterized protein. (531 aa)
	Cre-lst-4	CRE-LST-4 protein. (474 aa)
	CRE_13163	Uncharacterized protein. (906 aa)
	CRE_13811	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (333 aa)
	CRE_12421	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (712 aa)
	CRE_11600	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (506 aa)
	CRE_31649	Uncharacterized protein. (120 aa)
	CRE_05348	ZZ-type domain-containing protein. (239 aa)
	CRE_31629	Uncharacterized protein. (275 aa)
	CRE_13867	Uncharacterized protein. (252 aa)
	CRE_14463	Uncharacterized protein. (179 aa)
	CRE_20181	SH3 domain-containing protein. (246 aa)

Your Current Organism:

Caenorhabditis remanei

NCBI taxonomy Id: 31234
Other names: C. remanei, Caenorhabditis vulgaris

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRE_01610	CRE_11600	E3LGR8	E3NRK8	RING-CH-type domain-containing protein.	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.531
CRE_01610	CRE_12421	E3LGR8	E3NQB2	RING-CH-type domain-containing protein.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.531
CRE_01610	CRE_13447	E3LGR8	E3MR10	RING-CH-type domain-containing protein.	GED domain-containing protein.	0.531
CRE_01610	CRE_13811	E3LGR8	E3NNL9	RING-CH-type domain-containing protein.	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.531
CRE_01610	CRE_13935	E3LGR8	E3M8U9	RING-CH-type domain-containing protein.	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.480
CRE_01610	CRE_29048	E3LGR8	E3NA72	RING-CH-type domain-containing protein.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.531
CRE_01610	Cre-drp-1	E3LGR8	E3MR02	RING-CH-type domain-containing protein.	CRE-DRP-1 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.531
CRE_01610	Cre-dyn-1	E3LGR8	E3MCH2	RING-CH-type domain-containing protein.	CRE-DYN-1 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.531
CRE_01610	Cre-eat-3	E3LGR8	E3N380	RING-CH-type domain-containing protein.	CRE-EAT-3 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.567
CRE_01610	Cre-fis-1	E3LGR8	E3LQV3	RING-CH-type domain-containing protein.	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.	0.465
CRE_01610	Cre-fis-2	E3LGR8	E3MJT7	RING-CH-type domain-containing protein.	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.	0.465
CRE_01610	Cre-fzo-1	E3LGR8	E3M4X2	RING-CH-type domain-containing protein.	CRE-FZO-1 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.847
CRE_01610	Cre-pdr-1	E3LGR8	E3LYI0	RING-CH-type domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.421
CRE_02155	CRE_06694	E3LFC7	E3M101	Uncharacterized protein.	PX domain-containing protein.	0.410
CRE_02155	CRE_11600	E3LFC7	E3NRK8	Uncharacterized protein.	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.848
CRE_02155	CRE_12421	E3LFC7	E3NQB2	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.848
CRE_02155	CRE_13447	E3LFC7	E3MR10	Uncharacterized protein.	GED domain-containing protein.	0.848
CRE_02155	CRE_13811	E3LFC7	E3NNL9	Uncharacterized protein.	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.848
CRE_02155	CRE_14463	E3LFC7	E3NWU0	Uncharacterized protein.	Uncharacterized protein.	0.410
CRE_02155	CRE_17946	E3LFC7	E3MDQ1	Uncharacterized protein.	Uncharacterized protein.	0.886