(21 nodes) Negative regulation of actin filament polymerization network (Caenorhabditis remanei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRE_27974	Uncharacterized protein. (483 aa)
	CRE_05338	SH3 domain-containing protein. (308 aa)
	Cre-cap-2	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (271 aa)
	Cre-unc-78	CRE-UNC-78 protein. (644 aa)
	Cre-spc-1	CRE-SPC-1 protein. (2370 aa)
	Cre-pfn-2	Profilin; Belongs to the profilin family. (131 aa)
	Cre-add-1	CRE-ADD-1 protein. (687 aa)
	CRE_27654	Uncharacterized protein. (337 aa)
	Cre-vab-19	CRE-VAB-19 protein. (1085 aa)
	Cre-viln-1	CRE-VILN-1 protein. (910 aa)
	Cre-pfn-1	Profilin; Belongs to the profilin family. (132 aa)
	Cre-fli-1	CRE-FLI-1 protein. (1257 aa)
	CRE_23722	Uncharacterized protein. (504 aa)
	Cre-pfn-3	Profilin; Belongs to the profilin family. (126 aa)
	Cre-cap-1	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
	Cre-unc-94	CRE-UNC-94 protein. (406 aa)
	Cre-tmd-2	CRE-TMD-2 protein. (667 aa)
	Cre-add-2	CRE-ADD-2 protein. (613 aa)
	Cre-sma-1	CRE-SMA-1 protein. (4172 aa)
	Cre-unc-70	Spectrin beta chain; Belongs to the spectrin family. (2342 aa)
	Cre-eps-8	CRE-EPS-8 protein. (733 aa)

Your Current Organism:

Caenorhabditis remanei

NCBI taxonomy Id: 31234
Other names: C. remanei, Caenorhabditis vulgaris

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRE_05338	CRE_23722	E3NS71	E3ND03	SH3 domain-containing protein.	Uncharacterized protein.	0.670
CRE_05338	CRE_27654	E3NS71	E3MKR8	SH3 domain-containing protein.	Uncharacterized protein.	0.823
CRE_05338	CRE_27974	E3NS71	E3NS00	SH3 domain-containing protein.	Uncharacterized protein.	0.670
CRE_05338	Cre-cap-2	E3NS71	Q4TTM6	SH3 domain-containing protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.549
CRE_05338	Cre-vab-19	E3NS71	E3MZH9	SH3 domain-containing protein.	CRE-VAB-19 protein.	0.621
CRE_23722	CRE_05338	E3ND03	E3NS71	Uncharacterized protein.	SH3 domain-containing protein.	0.670
CRE_23722	CRE_27654	E3ND03	E3MKR8	Uncharacterized protein.	Uncharacterized protein.	0.848
CRE_23722	Cre-eps-8	E3ND03	E3NEP7	Uncharacterized protein.	CRE-EPS-8 protein.	0.670
CRE_23722	Cre-pfn-1	E3ND03	E3NAA8	Uncharacterized protein.	Profilin; Belongs to the profilin family.	0.709
CRE_23722	Cre-pfn-2	E3ND03	E3LE20	Uncharacterized protein.	Profilin; Belongs to the profilin family.	0.711
CRE_23722	Cre-pfn-3	E3ND03	E3MA14	Uncharacterized protein.	Profilin; Belongs to the profilin family.	0.724
CRE_23722	Cre-spc-1	E3ND03	E3LCP1	Uncharacterized protein.	CRE-SPC-1 protein.	0.616
CRE_23722	Cre-tmd-2	E3ND03	E3LZQ4	Uncharacterized protein.	CRE-TMD-2 protein.	0.645
CRE_23722	Cre-unc-78	E3ND03	E3LCE1	Uncharacterized protein.	CRE-UNC-78 protein.	0.533
CRE_23722	Cre-unc-94	E3ND03	E3M3M3	Uncharacterized protein.	CRE-UNC-94 protein.	0.683
CRE_23722	Cre-viln-1	E3ND03	E3N7I2	Uncharacterized protein.	CRE-VILN-1 protein.	0.719
CRE_27654	CRE_05338	E3MKR8	E3NS71	Uncharacterized protein.	SH3 domain-containing protein.	0.823
CRE_27654	CRE_23722	E3MKR8	E3ND03	Uncharacterized protein.	Uncharacterized protein.	0.848
CRE_27654	CRE_27974	E3MKR8	E3NS00	Uncharacterized protein.	Uncharacterized protein.	0.848
CRE_27654	Cre-cap-1	E3MKR8	E3M776	Uncharacterized protein.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.956