(75 nodes) SH2 domain superfamily network (Caenorhabditis remanei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRE_00479	Uncharacterized protein. (212 aa)
	CRE_00009	Uncharacterized protein. (230 aa)
	CRE_00559	Uncharacterized protein. (293 aa)
	Cre-nck-1	CRE-NCK-1 protein. (392 aa)
	CRE_01857	Tyrosine-protein kinase. (468 aa)
	CRE_18843	Tyrosine-protein kinase. (399 aa)
	CRE_28372	Tyrosine-protein kinase. (616 aa)
	CRE_28091	Tyrosine-protein kinase. (439 aa)
	Cre-frk-1	Tyrosine-protein kinase. (390 aa)
	CRE_28424	Tyrosine-protein kinase. (278 aa)
	Cre-kin-5	Tyrosine-protein kinase. (554 aa)
	CRE_28463	Tyrosine-protein kinase. (430 aa)
	CRE_28467	Tyrosine-protein kinase. (559 aa)
	CRE_28479	Tyrosine-protein kinase. (600 aa)
	CRE_27356	Uncharacterized protein. (212 aa)
	Cre-ptp-2	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (666 aa)
	CRE_29682	Tyrosine-protein kinase. (506 aa)
	CRE_29498	Tyrosine-protein kinase. (504 aa)
	Cre-kin-24	Tyrosine-protein kinase. (523 aa)
	CRE_29600	Tyrosine-protein kinase. (875 aa)
	CRE_29607	Tyrosine-protein kinase. (531 aa)
	CRE_29630	Tyrosine-protein kinase. (568 aa)
	CRE_03069	SH2 domain-containing protein. (232 aa)
	Cre-spe-8	Tyrosine-protein kinase. (519 aa)
	CRE_03640	SH2 domain-containing protein. (425 aa)
	Cre-src-1	Tyrosine-protein kinase. (525 aa)
	CRE_03755	Uncharacterized protein. (351 aa)
	CRE_04004	Tyrosine-protein kinase. (603 aa)
	CRE_04862	Tyrosine-protein kinase. (581 aa)
	Cre-abl-1	Tyrosine-protein kinase. (1287 aa)
	CRE_08043	Tyrosine-protein kinase. (445 aa)
	CRE_08044	Non-specific protein-tyrosine kinase. (394 aa)
	CRE_08045	Tyrosine-protein kinase. (456 aa)
	CRE_08092	Tyrosine-protein kinase. (432 aa)
	Cre-csk-1	CRE-CSK-1 protein. (1418 aa)
	Cre-shc-2	CRE-SHC-2 protein. (668 aa)
	CRE_11752	Tyrosine-protein kinase. (854 aa)
	CRE_10922	SH2 domain-containing protein. (524 aa)
	CRE_12476	Tyrosine-protein kinase. (437 aa)
	CRE_12480	Tyrosine-protein kinase. (437 aa)
	CRE_13374	Uncharacterized protein. (540 aa)
	CRE_14028	SH2 domain-containing protein. (187 aa)
	CRE_14042	Uncharacterized protein. (189 aa)
	Cre-sli-1	CRE-SLI-1 protein. (537 aa)
	Cre-vav-1	CRE-VAV-1 protein. (1020 aa)
	CRE_20186	Tyrosine-protein kinase. (541 aa)
	CRE_20209	Tyrosine-protein kinase. (476 aa)
	Cre-emb-5	Suppressor of Ty 6 homolog; May regulate transcriptional elongation by RNA polymerase II. (1521 aa)
	CRE_19717	Uncharacterized protein. (560 aa)
	CRE_22317	SH2 domain-containing protein. (293 aa)
	Cre-src-2	Tyrosine-protein kinase. (527 aa)
	Cre-shc-1	CRE-SHC-1 protein. (323 aa)
	CRE_24508	Tyrosine-protein kinase. (552 aa)
	CRE_23884	Tyrosine-protein kinase. (560 aa)
	CRE_23920	Tyrosine-protein kinase. (575 aa)
	Cre-sta-2	CRE-STA-2 protein. (567 aa)
	CRE_00964	Protein kinase domain-containing protein. (560 aa)
	CRE_04905	SH2 domain-containing protein. (516 aa)
	Cre-plc-3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
	CRE_16822	Protein kinase domain-containing protein. (530 aa)
	CRE_24560	Tyrosine-protein kinase. (431 aa)
	CRE_09694	Tyrosine-protein kinase. (495 aa)
	Cre-aap-1	CRE-AAP-1 protein. (576 aa)
	CRE_30068	Uncharacterized protein. (277 aa)
	Cre-ced-2	CRE-CED-2 protein. (294 aa)
	Cre-kin-14	Tyrosine-protein kinase. (382 aa)
	CRE_13740	Uncharacterized protein. (372 aa)
	CRE_24809	Tyrosine-protein kinase. (434 aa)
	Cre-sta-1	Signal transducer and activator of transcription. (714 aa)
	CRE_23737	Uncharacterized protein. (542 aa)
	CRE_13122	Tyrosine-protein kinase. (397 aa)
	CRE_07080	Non-specific protein-tyrosine kinase. (207 aa)
	CRE_15044	SH2 domain-containing protein. (524 aa)
	CRE_20596	Tyrosine-protein kinase. (503 aa)
	CRE_21635	Uncharacterized protein. (158 aa)

Your Current Organism:

Caenorhabditis remanei

NCBI taxonomy Id: 31234
Other names: C. remanei, Caenorhabditis vulgaris

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRE_00009	CRE_00964	E3LCA5	E3MI87	Uncharacterized protein.	Protein kinase domain-containing protein.	0.634
CRE_00009	CRE_01857	E3LCA5	E3LFV9	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_03069	E3LCA5	E3LWE0	Uncharacterized protein.	SH2 domain-containing protein.	0.890
CRE_00009	CRE_03755	E3LCA5	E3LY36	Uncharacterized protein.	Uncharacterized protein.	0.694
CRE_00009	CRE_04004	E3LCA5	E3LYB0	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_04862	E3LCA5	E3LYJ8	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_07080	E3LCA5	E3NK51	Uncharacterized protein.	Non-specific protein-tyrosine kinase.	0.634
CRE_00009	CRE_08043	E3LCA5	E3M319	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_08044	E3LCA5	E3M322	Uncharacterized protein.	Non-specific protein-tyrosine kinase.	0.634
CRE_00009	CRE_08045	E3LCA5	E3M324	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_08092	E3LCA5	E3M3C5	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_09694	E3LCA5	E3MX25	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_11752	E3LCA5	E3M4H1	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_12476	E3LCA5	E3M742	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_12480	E3LCA5	E3M747	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_13122	E3LCA5	E3NIM3	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_13374	E3LCA5	E3M8G6	Uncharacterized protein.	Uncharacterized protein.	0.634
CRE_00009	CRE_16822	E3LCA5	E3MS67	Uncharacterized protein.	Protein kinase domain-containing protein.	0.634
CRE_00009	CRE_18843	E3LCA5	E3LKV0	Uncharacterized protein.	Tyrosine-protein kinase.	0.634
CRE_00009	CRE_19717	E3LCA5	E3MDA5	Uncharacterized protein.	Uncharacterized protein.	0.634