STRINGSTRING
Cre-mcm-3 Cre-mcm-3 Cre-mcm-7 Cre-mcm-7 Cre-cdt-1 Cre-cdt-1 Cre-rpt-5 Cre-rpt-5 Cre-rpn-10 Cre-rpn-10 CRE_28562 CRE_28562 CRE_28272 CRE_28272 Cre-rpt-1 Cre-rpt-1 CRE_27381 CRE_27381 CRE_26482 CRE_26482 CRE_26065 CRE_26065 CRE_26066 CRE_26066 Cre-rpa-1 Cre-rpa-1 Cre-mcm-6 Cre-mcm-6 Cre-pri-1 Cre-pri-1 CRE_25584 CRE_25584 CRE_25310 CRE_25310 Cre-pbs-6 Cre-pbs-6 CRE_25146 CRE_25146 CRE_25147 CRE_25147 Cre-pas-1 Cre-pas-1 Cre-pas-6 Cre-pas-6 Cre-rpt-2 Cre-rpt-2 CRE_29638 CRE_29638 Cre-pbs-7 Cre-pbs-7 Cre-pas-5 Cre-pas-5 Cre-ubq-2 Cre-ubq-2 Cre-rpn-2 Cre-rpn-2 CRE_03180 CRE_03180 CRE_03184 CRE_03184 CRE_03983 CRE_03983 CRE_04677 CRE_04677 Cre-ubq-1 Cre-ubq-1 Cre-div-1 Cre-div-1 CRE_04614 CRE_04614 CRE_04615 CRE_04615 CRE_05743 CRE_05743 CRE_05746 CRE_05746 CRE_05547 CRE_05547 CRE_06288 CRE_06288 CRE_08032 CRE_08032 Cre-mcm-4 Cre-mcm-4 CRE_08300 CRE_08300 CRE_08190 CRE_08190 Cre-pbs-3 Cre-pbs-3 CRE_10866 CRE_10866 CRE_10867 CRE_10867 CRE_11090 CRE_11090 Cre-htz-1 Cre-htz-1 CRE_10017 CRE_10017 CRE_01514 CRE_01514 CRE_13961 CRE_13961 CRE_14692 CRE_14692 CRE_14579 CRE_14579 CRE_15276 CRE_15276 Cre-rpn-6 Cre-rpn-6 Cre-apc-11 Cre-apc-11 CRE_20353 CRE_20353 Cre-apc-2 Cre-apc-2 Cre-pbs-4 Cre-pbs-4 Cre-rpn-8 Cre-rpn-8 Cre-cdc-6 Cre-cdc-6 CRE_22877 CRE_22877 Cre-rpn-3 Cre-rpn-3 CRE_01039 CRE_01039 Cre-such-1 Cre-such-1 CRE_01016 CRE_01016 CRE_19220 CRE_19220 Cre-mcm-5 Cre-mcm-5 CRE_25628 CRE_25628 CRE_25701 CRE_25701 Cre-rpn-11 Cre-rpn-11 Cre-apc-10 Cre-apc-10 CRE_23600 CRE_23600 Cre-ubl-1 Cre-ubl-1 Cre-pas-3 Cre-pas-3 Cre-mat-1 Cre-mat-1 Cre-rpn-5 Cre-rpn-5 CRE_26733 CRE_26733 CRE_26734 CRE_26734 CRE_12205 CRE_12205 Cre-pri-2 Cre-pri-2 Cre-pbs-5 Cre-pbs-5 CRE_14909 CRE_14909 Cre-rpt-4 Cre-rpt-4 Cre-pole-2 Cre-pole-2 Cre-pbs-2 Cre-pbs-2 Cre-mcm-2 Cre-mcm-2 Cre-rpn-1 Cre-rpn-1 Cre-rpn-7 Cre-rpn-7 CRE_25761 CRE_25761 Cre-gfi-3 Cre-gfi-3 CRE_17500 CRE_17500 CRE_15697 CRE_15697 CRE_13713 CRE_13713 Cre-pbs-1 Cre-pbs-1 MCM7-2 MCM7-2 Cre-rpt-6 Cre-rpt-6 Cre-imb-1 Cre-imb-1 CRE_15218 CRE_15218 CRE_29242 CRE_29242 Cre-pas-2 Cre-pas-2 CRE_30262 CRE_30262 CRE_25974 CRE_25974 CRE_21650 CRE_21650 CRE_20125 CRE_20125 CRE_27959 CRE_27959 CRE_25994 CRE_25994 Cre-his-39 Cre-his-39 CRE_01515 CRE_01515 CRE_24376 CRE_24376 CRE_02168 CRE_02168 Cre-mat-2 Cre-mat-2 Cre-rpn-9 Cre-rpn-9 Cre-rpn-12 Cre-rpn-12 Cre-orc-2 Cre-orc-2 Cre-dnj-23 Cre-dnj-23 Cre-emb-27 Cre-emb-27 Cre-pas-7 Cre-pas-7 CRE_09394 CRE_09394 CRE_18971 CRE_18971 Cre-his-31 Cre-his-31 MCM7 MCM7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cre-mcm-3CRE-MCM-3 protein; Belongs to the MCM family. (814 aa)
Cre-mcm-7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (730 aa)
Cre-cdt-1CRE-CDT-1 protein. (705 aa)
Cre-rpt-5CRE-RPT-5 protein; Belongs to the AAA ATPase family. (430 aa)
Cre-rpn-10CRE-RPN-10 protein. (350 aa)
CRE_28562Uncharacterized protein; Belongs to the AAA ATPase family. (309 aa)
CRE_28272AAA domain-containing protein; Belongs to the AAA ATPase family. (409 aa)
Cre-rpt-1CRE-RPT-1 protein; Belongs to the AAA ATPase family. (435 aa)
CRE_27381Histone H2B; Belongs to the histone H2B family. (156 aa)
CRE_26482Uncharacterized protein. (197 aa)
CRE_26065CBFD_NFYB_HMF domain-containing protein. (212 aa)
CRE_26066CBFD_NFYB_HMF domain-containing protein. (212 aa)
Cre-rpa-1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (656 aa)
Cre-mcm-6DNA helicase; Belongs to the MCM family. (828 aa)
Cre-pri-1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (410 aa)
CRE_25584MPN domain-containing protein. (319 aa)
CRE_25310ANAPC4_WD40 domain-containing protein. (111 aa)
Cre-pbs-6Proteasome subunit beta. (258 aa)
CRE_25146Uncharacterized protein. (568 aa)
CRE_25147CPG4 domain-containing protein. (713 aa)
Cre-pas-1Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (246 aa)
Cre-pas-6Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (271 aa)
Cre-rpt-2CRE-RPT-2 protein; Belongs to the AAA ATPase family. (443 aa)
CRE_29638TPR_REGION domain-containing protein. (652 aa)
Cre-pbs-7Proteasome subunit beta; Belongs to the peptidase T1B family. (236 aa)
Cre-pas-5Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (258 aa)
Cre-ubq-2CRE-UBQ-2 protein. (128 aa)
Cre-rpn-226S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (978 aa)
CRE_03180CBFD_NFYB_HMF domain-containing protein. (150 aa)
CRE_03184AAA domain-containing protein; Belongs to the AAA ATPase family. (443 aa)
CRE_03983Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (446 aa)
CRE_04677DNA polymerase. (1489 aa)
Cre-ubq-1CRE-UBQ-1 protein. (920 aa)
Cre-div-1DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (581 aa)
CRE_04614Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (665 aa)
CRE_04615Uncharacterized protein. (398 aa)
CRE_05743Histone H2B; Belongs to the histone H2B family. (163 aa)
CRE_05746Histone H2B; Belongs to the histone H2B family. (120 aa)
CRE_05547Histone H2B; Belongs to the histone H2B family. (163 aa)
CRE_06288MPN domain-containing protein. (323 aa)
CRE_08032Histone H2B; Belongs to the histone H2B family. (123 aa)
Cre-mcm-4DNA helicase; Belongs to the MCM family. (817 aa)
CRE_08300DOC domain-containing protein. (216 aa)
CRE_08190Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (195 aa)
Cre-pbs-3Proteasome subunit beta. (204 aa)
CRE_10866Uncharacterized protein. (449 aa)
CRE_10867Uncharacterized protein. (264 aa)
CRE_11090PCI domain-containing protein. (489 aa)
Cre-htz-1Histone H2A; Belongs to the histone H2A family. (141 aa)
CRE_10017Histone H2B; Belongs to the histone H2B family. (128 aa)
CRE_01514Histone H2B; Belongs to the histone H2B family. (122 aa)
CRE_13961DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2200 aa)
CRE_14692Uncharacterized protein. (89 aa)
CRE_14579AAA domain-containing protein; Belongs to the AAA ATPase family. (404 aa)
CRE_15276TPR_REGION domain-containing protein. (800 aa)
Cre-rpn-6CRE-RPN-6 protein. (420 aa)
Cre-apc-11CRE-APC-11 protein. (140 aa)
CRE_20353Uncharacterized protein. (507 aa)
Cre-apc-2CRE-APC-2 protein; Belongs to the cullin family. (732 aa)
Cre-pbs-4Proteasome subunit beta. (204 aa)
Cre-rpn-8CRE-RPN-8 protein. (362 aa)
Cre-cdc-6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (553 aa)
CRE_22877Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (239 aa)
Cre-rpn-3CRE-RPN-3 protein. (506 aa)
CRE_01039Mcm10 domain-containing protein. (692 aa)
Cre-such-1CRE-SUCH-1 protein. (794 aa)
CRE_01016Uncharacterized protein. (266 aa)
CRE_19220Ubiquitin-like domain-containing protein. (81 aa)
Cre-mcm-5DNA helicase; Belongs to the MCM family. (759 aa)
CRE_25628TPR_REGION domain-containing protein. (673 aa)
CRE_25701Uncharacterized protein. (117 aa)
Cre-rpn-11CRE-RPN-11 protein. (312 aa)
Cre-apc-10CRE-APC-10 protein. (206 aa)
CRE_23600AAA domain-containing protein; Belongs to the AAA ATPase family. (329 aa)
Cre-ubl-1CRE-UBL-1 protein. (160 aa)
Cre-pas-3Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (250 aa)
Cre-mat-1CRE-MAT-1 protein. (459 aa)
Cre-rpn-5CRE-RPN-5 protein. (507 aa)
CRE_26733Uncharacterized protein. (338 aa)
CRE_26734Uncharacterized protein. (103 aa)
CRE_12205PCI domain-containing protein. (472 aa)
Cre-pri-2DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (504 aa)
Cre-pbs-5CRE-PBS-5 protein. (284 aa)
CRE_14909KxDL domain-containing protein. (72 aa)
Cre-rpt-4CRE-RPT-4 protein; Belongs to the AAA ATPase family. (492 aa)
Cre-pole-2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (520 aa)
Cre-pbs-2CRE-PBS-2 protein. (290 aa)
Cre-mcm-2DNA helicase; Belongs to the MCM family. (877 aa)
Cre-rpn-126S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (989 aa)
Cre-rpn-7CRE-RPN-7 protein. (409 aa)
CRE_25761PCI domain-containing protein. (372 aa)
Cre-gfi-3CRE-GFI-3 protein. (807 aa)
CRE_17500Uncharacterized protein. (706 aa)
CRE_15697Ribosomal_L40e domain-containing protein. (62 aa)
CRE_13713Uncharacterized protein. (657 aa)
Cre-pbs-1Proteasome subunit beta. (239 aa)
MCM7-2DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (77 aa)
Cre-rpt-6CRE-RPT-6 protein; Belongs to the AAA ATPase family. (408 aa)
Cre-imb-1CRE-IMB-1 protein. (899 aa)
CRE_15218Histone H2B; Belongs to the histone H2B family. (122 aa)
CRE_29242Uncharacterized protein. (302 aa)
Cre-pas-2Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (231 aa)
CRE_30262Uncharacterized protein. (101 aa)
CRE_25974AAA_lid_3 domain-containing protein. (114 aa)
CRE_21650Importin N-terminal domain-containing protein. (145 aa)
CRE_20125Uncharacterized protein. (686 aa)
CRE_27959KxDL domain-containing protein. (114 aa)
CRE_25994Uncharacterized protein. (692 aa)
Cre-his-39Histone H2B; Belongs to the histone H2B family. (64 aa)
CRE_01515Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (90 aa)
CRE_24376Uncharacterized protein. (63 aa)
CRE_02168Uncharacterized protein. (375 aa)
Cre-mat-2CRE-MAT-2 protein. (1518 aa)
Cre-rpn-9CRE-RPN-9 protein. (390 aa)
Cre-rpn-12CRE-RPN-12 protein. (250 aa)
Cre-orc-2CRE-ORC-2 protein. (430 aa)
Cre-dnj-23CRE-DNJ-23 protein. (243 aa)
Cre-emb-27CRE-EMB-27 protein. (666 aa)
Cre-pas-7Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (250 aa)
CRE_09394AAA domain-containing protein; Belongs to the AAA ATPase family. (416 aa)
CRE_18971Histone H2B; Belongs to the histone H2B family. (163 aa)
Cre-his-31Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (440 aa)
Your Current Organism:
Caenorhabditis remanei
NCBI taxonomy Id: 31234
Other names: C. remanei, Caenorhabditis vulgaris
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