(63 nodes) Mitophagy - animal network (Caenorhabditis remanei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cre-src-1	Tyrosine-protein kinase. (525 aa)
	Cre-ubq-2	CRE-UBQ-2 protein. (128 aa)
	CRE_29471	Uncharacterized protein. (221 aa)
	Cre-rab-7	CRE-RAB-7 protein. (245 aa)
	Cre-lgg-1	Protein lgg. (123 aa)
	Cre-fis-1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (143 aa)
	Cre-dct-1	CRE-DCT-1 protein. (214 aa)
	Cre-din-1	CRE-DIN-1 protein. (2318 aa)
	CRE_01724	SPOC domain-containing protein. (574 aa)
	CRE_02121	Uncharacterized protein. (1140 aa)
	CRE_01769	Uncharacterized protein. (137 aa)
	Cre-jun-1	CRE-JUN-1 protein. (317 aa)
	CRE_01904	Uncharacterized protein. (203 aa)
	Cre-atg-9	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (921 aa)
	Cre-daf-16	CRE-DAF-16 protein. (528 aa)
	Cre-kin-3	CRE-KIN-3 protein; Belongs to the protein kinase superfamily. (360 aa)
	CRE_26891	Uncharacterized protein. (391 aa)
	CRE_23824	Mitogen-activated protein kinase. (463 aa)
	CRE_06198	USP domain-containing protein; Belongs to the peptidase C19 family. (365 aa)
	Cre-kgb-1	Mitogen-activated protein kinase. (389 aa)
	CRE_20984	Uncharacterized protein. (367 aa)
	CRE_20055	Uncharacterized protein. (190 aa)
	Cre-cyk-3	CRE-CYK-3 protein. (1168 aa)
	Cre-ikke-1	CRE-IKKE-1 protein. (792 aa)
	CRE_05205	ZZ-type domain-containing protein. (581 aa)
	Cre-jnk-1	Mitogen-activated protein kinase. (495 aa)
	CRE_15697	Ribosomal_L40e domain-containing protein. (62 aa)
	CRE_13065	ZZ-type domain-containing protein. (202 aa)
	CRE_13064	ZZ-type domain-containing protein. (218 aa)
	Cre-hlh-30	CRE-HLH-30 protein. (631 aa)
	CRE_24714	Ubiquitin carboxyl-terminal hydrolase. (901 aa)
	Cre-ubl-1	CRE-UBL-1 protein. (160 aa)
	CRE_24573	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (300 aa)
	CRE_15480	Uncharacterized protein. (672 aa)
	Cre-bec-1	CRE-BEC-1 protein. (374 aa)
	CRE_04943	Uncharacterized protein. (148 aa)
	CRE_04940	Uncharacterized protein. (194 aa)
	Cre-zip-3	CRE-ZIP-3 protein. (312 aa)
	CRE_04077	Rab-GAP TBC domain-containing protein. (628 aa)
	Cre-efl-2	CRE-EFL-2 protein. (337 aa)
	Cre-tomm-7	CRE-TOMM-7 protein. (97 aa)
	CRE_28791	Protein kinase domain-containing protein. (388 aa)
	Cre-fis-2	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (151 aa)
	Cre-pgam-5	CRE-PGAM-5 protein. (324 aa)
	CRE_20749	Uncharacterized protein. (501 aa)
	CRE_21280	USP8_dimer domain-containing protein. (306 aa)
	CRE_21168	Uncharacterized protein. (171 aa)
	Cre-hif-1	CRE-HIF-1 protein. (732 aa)
	Cre-ras-2	CRE-RAS-2 protein. (211 aa)
	Cre-atf-5	CRE-ATF-5 protein. (243 aa)
	CRE_13931	Uncharacterized protein. (465 aa)
	Cre-let-60	CRE-LET-60 protein. (184 aa)
	CRE_10249	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (650 aa)
	Cre-fzo-1	CRE-FZO-1 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (804 aa)
	Cre-pink-1	CRE-PINK-1 protein. (638 aa)
	Cre-pek-1	CRE-PEK-1 protein. (1075 aa)
	Cre-ras-1	CRE-RAS-1 protein. (211 aa)
	CRE_05695	Uncharacterized protein. (368 aa)
	Cre-ubq-1	CRE-UBQ-1 protein. (920 aa)
	Cre-pdr-1	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (387 aa)
	Cre-kin-10	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (230 aa)
	Cre-atg-5	Autophagy protein 5; Involved in autophagic vesicle formation. (287 aa)
	CRE_02994	Ubiquitin carboxyl-terminal hydrolase. (492 aa)

Your Current Organism:

Caenorhabditis remanei

NCBI taxonomy Id: 31234
Other names: C. remanei, Caenorhabditis vulgaris

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRE_01724	CRE_10249	E3LF45	E3M644	SPOC domain-containing protein.	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.	0.650
CRE_01769	CRE_04077	E3LFC9	E3MMT7	Uncharacterized protein.	Rab-GAP TBC domain-containing protein.	0.573
CRE_01769	CRE_20055	E3LFC9	E3NHH6	Uncharacterized protein.	Uncharacterized protein.	0.947
CRE_01769	Cre-atg-5	E3LFC9	E3LXS9	Uncharacterized protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.773
CRE_01769	Cre-fis-1	E3LFC9	E3LQV3	Uncharacterized protein.	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.	0.575
CRE_01769	Cre-fis-2	E3LFC9	E3MJT7	Uncharacterized protein.	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.	0.456
CRE_01769	Cre-fzo-1	E3LFC9	E3M4X2	Uncharacterized protein.	CRE-FZO-1 protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.515
CRE_01769	Cre-ikke-1	E3LFC9	E3NFZ1	Uncharacterized protein.	CRE-IKKE-1 protein.	0.676
CRE_01769	Cre-kin-10	E3LFC9	E3LYC1	Uncharacterized protein.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.952
CRE_01769	Cre-kin-3	E3LFC9	E3LMP5	Uncharacterized protein.	CRE-KIN-3 protein; Belongs to the protein kinase superfamily.	0.956
CRE_01769	Cre-lgg-1	E3LFC9	E3LR71	Uncharacterized protein.	Protein lgg.	0.990
CRE_01769	Cre-pdr-1	E3LFC9	E3LYI0	Uncharacterized protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.521
CRE_01769	Cre-pgam-5	E3LFC9	E3MJ58	Uncharacterized protein.	CRE-PGAM-5 protein.	0.947
CRE_01769	Cre-pink-1	E3LFC9	E3M4K9	Uncharacterized protein.	CRE-PINK-1 protein.	0.521
CRE_01769	Cre-src-1	E3LFC9	E3LXJ8	Uncharacterized protein.	Tyrosine-protein kinase.	0.959
CRE_01904	CRE_23824	E3LG73	E3NRT8	Uncharacterized protein.	Mitogen-activated protein kinase.	0.939
CRE_01904	CRE_28791	E3LG73	E3MK34	Uncharacterized protein.	Protein kinase domain-containing protein.	0.939
CRE_01904	Cre-atf-5	E3LG73	E3MC58	Uncharacterized protein.	CRE-ATF-5 protein.	0.730
CRE_01904	Cre-daf-16	E3LG73	E3LMN9	Uncharacterized protein.	CRE-DAF-16 protein.	0.504
CRE_01904	Cre-hif-1	E3LG73	E3MF08	Uncharacterized protein.	CRE-HIF-1 protein.	0.623