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| | aroK | Putative shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (163 aa) |
| | EAQ99941.1 | Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (279 aa) |
| | EAQ99656.1 | Asparagine synthetase B. (554 aa) |
| | EAR02268.1 | L-asparaginase I. (342 aa) |
| | EAR02440.1 | Probable L-serine dehydratase, alpha chain. (526 aa) |
| | EAR02463.1 | Predicted dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (337 aa) |
| | EAR02471.1 | Aspartate kinase III; Belongs to the aspartokinase family. (416 aa) |
| | EAR02732.1 | Oxidoreductase, aldo/keto reductase family protein. (282 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa) |
| | EAR02895.1 | Hypothetical protein. (128 aa) |
| | EAR02910.1 | Hypothetical protein; Belongs to the glycerate kinase type-1 family. (374 aa) |
| | EAR03022.1 | Cys/Met metabolism PLP-dependent enzyme superfamily protein. (384 aa) |
| | katG | Catalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (721 aa) |
| | ahcY | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (438 aa) |
| | EAR00544.1 | Hypothetical protein. (150 aa) |
| | EAR00945.1 | Putative shikimate 5-dehydrogenase. (248 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (400 aa) |
| | EAQ99710.1 | 4-amino-4-deoxychorismate lyase, putative. (281 aa) |
| | EAR01159.1 | Cystathionine beta-lyase. (391 aa) |
| | EAR01189.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (354 aa) |
| | EAR01207.1 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (353 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (347 aa) |
| | hisB | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (377 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (193 aa) |
| | EAR01231.1 | Acetyltransferase. (141 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (244 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (242 aa) |
| | EAR01234.1 | Hypothetical protein. (193 aa) |
| | EAR01235.1 | Asp/Glu racemase:Aspartate racemase; Belongs to the aspartate/glutamate racemases family. (231 aa) |
| | hisI | Histidine biosynthesis bifunctional protein; In the N-terminal section; belongs to the PRA-CH family. (200 aa) |
| | EAR01299.1 | Glyoxylate/hydroxypyruvate reductase; 6-phosphogluconate dehydrogenase, NAD-binding:D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein. (309 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (354 aa) |
| | leuC | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa) |
| | EAR01493.1 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa) |
| | EAR01494.1 | Putative alpha-isopropylmalate synthase 2; Belongs to the alpha-IPM synthase/homocitrate synthase family. (496 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (351 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (416 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa) |
| | EAR01501.1 | Putative acetohydroxyacid synthase small subunit. (183 aa) |
| | EAR01502.1 | Acetolactate synthase large subunit. (577 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (558 aa) |
| | EAR01520.1 | Histidinol-phosphate aminotransferase. (371 aa) |
| | EAR00235.1 | Para-aminobenzoate synthase component I. (435 aa) |
| | EAR00240.1 | Cystathionine beta-lyase. (406 aa) |
| | EAR00284.1 | Cystathionine beta-synthase. (346 aa) |
| | EAR00330.1 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (474 aa) |
| | EAR00368.1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (390 aa) |
| | EAR00369.1 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (372 aa) |
| | EAR01575.1 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (627 aa) |
| | EAR01655.1 | Aromatic-L-amino-acid decarboxylase. (474 aa) |
| | EAR01791.1 | Flavin-containing amine oxidase. (479 aa) |
| | EAR01870.1 | Aspartokinase/homoserine dehydrogenase. (814 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa) |
| | EAR01872.1 | Threonine synthase. (431 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (139 aa) |
| | EAR02000.1 | Decarboxylase, pyridoxal-dependent. (497 aa) |
| | EAR00659.1 | Anthranilate synthase component I. (466 aa) |
| | EAR00660.1 | Anthranilate synthase component II. (189 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (330 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (261 aa) |
| | trpF | Putative N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (220 aa) |
| | trpB-2 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (260 aa) |
| | EAR00666.1 | Hypothetical protein. (74 aa) |
| | EAR00667.1 | Putative peptidase. (498 aa) |
| | EAR00698.1 | Aspartate aminotransferase. (397 aa) |
| | gpmI | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
| | EAR00754.1 | Putative aspartate aminotransferase. (395 aa) |
| | aroA | Putative 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (409 aa) |
| | EAR00820.1 | Hypothetical protein. (224 aa) |
| | EAR00821.1 | Putative chorismate mutase. (360 aa) |
| | EAR00822.1 | Prephenate dehydrogenase. (285 aa) |
| | EAR00823.1 | Putative aminotransferase. (381 aa) |
| | EAR00824.1 | Putative prefrenate dehydratase. (275 aa) |
| | EAR00828.1 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (317 aa) |
| | EAR00829.1 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (896 aa) |
| | EAR00831.1 | 5-methyltetrahydrofolate--homocysteine methyltransferase. (330 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (389 aa) |
| | EAR00842.1 | Bifunctional aspartokinase I/homoserine dehydrogenase I. (1128 aa) |
| | EAR00843.1 | O-acetyl-L-homoserine sulfhydrylase. (430 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (418 aa) |
