STRINGSTRING
EAQ99941.1 EAQ99941.1 EAR02463.1 EAR02463.1 EAR02471.1 EAR02471.1 asd asd EAR02910.1 EAR02910.1 EAR03022.1 EAR03022.1 ahcY ahcY EAR00544.1 EAR00544.1 EAQ99710.1 EAQ99710.1 EAR01159.1 EAR01159.1 EAR01189.1 EAR01189.1 serC serC leuC leuC EAR01493.1 EAR01493.1 EAR01494.1 EAR01494.1 leuB leuB ilvA ilvA ilvC ilvC EAR01501.1 EAR01501.1 EAR01502.1 EAR01502.1 ilvD ilvD EAR00240.1 EAR00240.1 EAR00284.1 EAR00284.1 EAR00368.1 EAR00368.1 EAR00369.1 EAR00369.1 EAR01575.1 EAR01575.1 EAR01870.1 EAR01870.1 thrB thrB EAR01872.1 EAR01872.1 gpmI gpmI EAR00828.1 EAR00828.1 EAR00829.1 EAR00829.1 EAR00831.1 EAR00831.1 metZ metZ EAR00842.1 EAR00842.1 EAR00843.1 EAR00843.1 metK metK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EAQ99941.1Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (279 aa)
EAR02463.1Predicted dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (337 aa)
EAR02471.1Aspartate kinase III; Belongs to the aspartokinase family. (416 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa)
EAR02910.1Hypothetical protein; Belongs to the glycerate kinase type-1 family. (374 aa)
EAR03022.1Cys/Met metabolism PLP-dependent enzyme superfamily protein. (384 aa)
ahcYS-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (438 aa)
EAR00544.1Hypothetical protein. (150 aa)
EAQ99710.14-amino-4-deoxychorismate lyase, putative. (281 aa)
EAR01159.1Cystathionine beta-lyase. (391 aa)
EAR01189.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (354 aa)
leuCIsopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
EAR01493.13-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa)
EAR01494.1Putative alpha-isopropylmalate synthase 2; Belongs to the alpha-IPM synthase/homocitrate synthase family. (496 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (351 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (416 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa)
EAR01501.1Putative acetohydroxyacid synthase small subunit. (183 aa)
EAR01502.1Acetolactate synthase large subunit. (577 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (558 aa)
EAR00240.1Cystathionine beta-lyase. (406 aa)
EAR00284.1Cystathionine beta-synthase. (346 aa)
EAR00368.12-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (390 aa)
EAR00369.13-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (372 aa)
EAR01575.1D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (627 aa)
EAR01870.1Aspartokinase/homoserine dehydrogenase. (814 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa)
EAR01872.1Threonine synthase. (431 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa)
EAR00828.15,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (317 aa)
EAR00829.15-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (896 aa)
EAR00831.15-methyltetrahydrofolate--homocysteine methyltransferase. (330 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (389 aa)
EAR00842.1Bifunctional aspartokinase I/homoserine dehydrogenase I. (1128 aa)
EAR00843.1O-acetyl-L-homoserine sulfhydrylase. (430 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (418 aa)
Your Current Organism:
Maribacter sp. HTCC2170
NCBI taxonomy Id: 313603
Other names: Flavobacteriales bacterium HTCC2170, M. sp. HTCC2170
Server load: low (36%) [HD]