STRINGSTRING
EAQ99607.1 EAQ99607.1 EAR00081.1 EAR00081.1 EAR00148.1 EAR00148.1 EAR00152.1 EAR00152.1 guaB guaB pyrD pyrD EAQ99964.1 EAQ99964.1 EAQ99971.1 EAQ99971.1 apt apt EAR00037.1 EAR00037.1 folD folD carA carA adk adk purK purK purE purE nadK nadK EAR02181.1 EAR02181.1 EAR02454.1 EAR02454.1 EAR02587.1 EAR02587.1 nadD nadD EAR02627.1 EAR02627.1 purD purD tdk tdk EAR02925.1 EAR02925.1 purN purN EAR02988.1 EAR02988.1 EAQ99756.1 EAQ99756.1 panD panD panC panC EAQ99895.1 EAQ99895.1 EAR00510.1 EAR00510.1 coaX coaX surE surE purH purH purA purA ribH ribH EAR01025.1 EAR01025.1 EAR01423.1 EAR01423.1 EAR01453.1 EAR01453.1 ribB ribB EAR00264.1 EAR00264.1 panB panB EAR00415.1 EAR00415.1 EAR00420.1 EAR00420.1 EAR00421.1 EAR00421.1 EAR01537.1 EAR01537.1 EAR01573.1 EAR01573.1 EAR01582.1 EAR01582.1 cobB cobB EAR01594.1 EAR01594.1 EAR01611.1 EAR01611.1 purL purL EAR01819.1 EAR01819.1 pyrB pyrB EAR01895.1 EAR01895.1 guaA guaA EAQ99829.1 EAQ99829.1 coaD coaD pyrE pyrE EAR00804.1 EAR00804.1 EAR00847.1 EAR00847.1 thyA thyA EAR00860.1 EAR00860.1 EAR00861.1 EAR00861.1 EAR00877.1 EAR00877.1 EAR00885.1 EAR00885.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EAQ99607.1Pyrimidine regulatory protein PyrR. (180 aa)
EAR00081.1Purine nucleoside phosphorylase. (232 aa)
EAR00148.1MazG family protein. (257 aa)
EAR00152.1Glutamine amidotransferase. (238 aa)
guaBPutative inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (346 aa)
EAQ99964.1Orotidine 5'-phosphate decarboxylase. (274 aa)
EAQ99971.1Putative phosphoribosylformylglycinamidine cyclo-ligase. (392 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
EAR00037.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (273 aa)
folDPutative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
carACarbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (375 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (368 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (384 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
nadKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (293 aa)
EAR02181.1Deoxyguanosine kinase/deoxyadenosine kinase subunit. (381 aa)
EAR02454.1Riboflavin kinase / FAD synthetase; Belongs to the ribF family. (308 aa)
EAR02587.1dGTP triphosphohydrolase. (447 aa)
nadDNicotinic acid mononucleotide adenyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (194 aa)
EAR02627.1Deoxycytidylate deaminase. (147 aa)
purDPutative phosphoribosylamine--glycine ligase; Belongs to the GARS family. (423 aa)
tdkPutative thymidine kinase. (214 aa)
EAR02925.1Amidophosphoribosyltransferase. (632 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (189 aa)
EAR02988.1Hypothetical protein. (169 aa)
EAQ99756.1Putative dolichol-P-glucose synthetase. (321 aa)
panDAspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa)
panCPutative pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa)
EAQ99895.1Dihydroorotase. (444 aa)
EAR00510.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (273 aa)
coaXPutative regulatory protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (242 aa)
surEAcid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (260 aa)
purHBifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (509 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
ribHRiboflavin synthase subunit beta; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (160 aa)
EAR01025.1Uridine kinase. (202 aa)
EAR01423.1Phosphorylase family protein. (288 aa)
EAR01453.1Hypothetical protein. (194 aa)
ribBPutative riboflavin biosynthesis protein; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (380 aa)
EAR00264.1Dihydroorotase. (418 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (272 aa)
EAR00415.1Flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (401 aa)
EAR00420.1Putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase. (254 aa)
EAR00421.1Possible secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (303 aa)
EAR01537.1Putative riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (350 aa)
EAR01573.1Putative nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (285 aa)
EAR01582.1Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (190 aa)
cobBHypothetical protein; Belongs to the sirtuin family. Class III subfamily. (230 aa)
EAR01594.1Adenylosuccinate lyase. (235 aa)
EAR01611.1Carbamoyl-phosphate synthase, large subunit. (950 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1218 aa)
EAR01819.1Uracil phosphoribosyltransferase. (223 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa)
EAR01895.1Pyrimidine regulatory protein PyrR. (179 aa)
guaABifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. (510 aa)
EAQ99829.1Putative competence-damage inducible; Belongs to the CinA family. (415 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (151 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
EAR00804.1Putative NH(3)-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (262 aa)
EAR00847.1Deoxynucleoside kinase subfamily, putative. (204 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (274 aa)
EAR00860.1Hypothetical protein. (128 aa)
EAR00861.1DfrA; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (159 aa)
EAR00877.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (160 aa)
EAR00885.1Folylpolyglutamate synthase. (403 aa)
Your Current Organism:
Maribacter sp. HTCC2170
NCBI taxonomy Id: 313603
Other names: Flavobacteriales bacterium HTCC2170, M. sp. HTCC2170
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