STRINGSTRING
EAQ99607.1 EAQ99607.1 EAR00081.1 EAR00081.1 EAR00148.1 EAR00148.1 EAR00152.1 EAR00152.1 guaB guaB pyrD pyrD EAQ99964.1 EAQ99964.1 EAQ99971.1 EAQ99971.1 apt apt folD folD carA carA adk adk purK purK purE purE EAR02587.1 EAR02587.1 EAR02627.1 EAR02627.1 purD purD tdk tdk EAR02925.1 EAR02925.1 purN purN EAR02988.1 EAR02988.1 EAQ99895.1 EAQ99895.1 EAR00510.1 EAR00510.1 surE surE purH purH purA purA EAR01025.1 EAR01025.1 EAR01423.1 EAR01423.1 EAR00264.1 EAR00264.1 EAR00420.1 EAR00420.1 EAR00421.1 EAR00421.1 EAR01582.1 EAR01582.1 EAR01594.1 EAR01594.1 EAR01611.1 EAR01611.1 purL purL EAR01819.1 EAR01819.1 pyrB pyrB EAR01895.1 EAR01895.1 guaA guaA pyrE pyrE EAR00847.1 EAR00847.1 EAR00877.1 EAR00877.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EAQ99607.1Pyrimidine regulatory protein PyrR. (180 aa)
EAR00081.1Purine nucleoside phosphorylase. (232 aa)
EAR00148.1MazG family protein. (257 aa)
EAR00152.1Glutamine amidotransferase. (238 aa)
guaBPutative inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (346 aa)
EAQ99964.1Orotidine 5'-phosphate decarboxylase. (274 aa)
EAQ99971.1Putative phosphoribosylformylglycinamidine cyclo-ligase. (392 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
folDPutative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
carACarbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (375 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (368 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (384 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
EAR02587.1dGTP triphosphohydrolase. (447 aa)
EAR02627.1Deoxycytidylate deaminase. (147 aa)
purDPutative phosphoribosylamine--glycine ligase; Belongs to the GARS family. (423 aa)
tdkPutative thymidine kinase. (214 aa)
EAR02925.1Amidophosphoribosyltransferase. (632 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (189 aa)
EAR02988.1Hypothetical protein. (169 aa)
EAQ99895.1Dihydroorotase. (444 aa)
EAR00510.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (273 aa)
surEAcid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (260 aa)
purHBifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (509 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
EAR01025.1Uridine kinase. (202 aa)
EAR01423.1Phosphorylase family protein. (288 aa)
EAR00264.1Dihydroorotase. (418 aa)
EAR00420.1Putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase. (254 aa)
EAR00421.1Possible secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (303 aa)
EAR01582.1Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (190 aa)
EAR01594.1Adenylosuccinate lyase. (235 aa)
EAR01611.1Carbamoyl-phosphate synthase, large subunit. (950 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1218 aa)
EAR01819.1Uracil phosphoribosyltransferase. (223 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (308 aa)
EAR01895.1Pyrimidine regulatory protein PyrR. (179 aa)
guaABifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. (510 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
EAR00847.1Deoxynucleoside kinase subfamily, putative. (204 aa)
EAR00877.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (160 aa)
Your Current Organism:
Maribacter sp. HTCC2170
NCBI taxonomy Id: 313603
Other names: Flavobacteriales bacterium HTCC2170, M. sp. HTCC2170
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