STRINGSTRING
NSP_8500 NSP_8500 polA polA NSP_11410 NSP_11410 uvrA uvrA NSP_11980 NSP_11980 recG recG uvrB uvrB NSP_13450 NSP_13450 ligA ligA NSP_1610 NSP_1610 NSP_18430 NSP_18430 NSP_18920 NSP_18920 mutS2 mutS2 recA recA ruvA ruvA lexA lexA mfd mfd NSP_27090 NSP_27090 NSP_27460 NSP_27460 NSP_28140 NSP_28140 NSP_30180 NSP_30180 nth nth NSP_31240 NSP_31240 recO recO ruvB ruvB NSP_35730 NSP_35730 radA radA NSP_36100 NSP_36100 NSP_36230 NSP_36230 NSP_36830 NSP_36830 NSP_37320 NSP_37320 NSP_37350 NSP_37350 NSP_380 NSP_380 NSP_40440 NSP_40440 NSP_40450 NSP_40450 NSP_40750 NSP_40750 NSP_40790 NSP_40790 NSP_9870 NSP_9870 NSP_41010 NSP_41010 NSP_42620 NSP_42620 NSP_43200 NSP_43200 mutL mutL NSP_46520 NSP_46520 ruvC ruvC NSP_4900 NSP_4900 NSP_51050 NSP_51050 uvrC uvrC NSP_52010 NSP_52010 NSP_52670 NSP_52670 recF recF NSP_53210 NSP_53210 NSP_53320 NSP_53320 mutS mutS recR recR NSP_6900 NSP_6900 NSP_6910 NSP_6910 NSP_700 NSP_700
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NSP_8500Exodeoxyribonuclease III; Nsp8500; ORF_ID:nsp8500. (260 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (972 aa)
NSP_11410ATPase-like protein; Nsp11410; ORF_ID:nsp11410. (391 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (956 aa)
NSP_11980Cytosine-specific DNA methyltransferase; Nsp11980; ORF_ID:nsp11980. (278 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (823 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (665 aa)
NSP_13450Hypothetical protein; Nsp13450; ORF_ID:nsp13450. (430 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (678 aa)
NSP_1610Haloacid dehalogenase/epoxide hydrolase family; Nsp1610; ORF_ID:nsp1610. (243 aa)
NSP_18430Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (264 aa)
NSP_18920Hypothetical protein; Nsp18920; ORF_ID:nsp18920. (391 aa)
mutS2Recombination inhibitory protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (817 aa)
recARecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (356 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (213 aa)
lexASOS-response repressor and protease LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (208 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1164 aa)
NSP_27090Helicase, C-terminal:Type III restriction enzyme, res subunit:DEAD/DEAH box helicase, N-terminal; Nsp27090; ORF_ID:nsp27090. (2169 aa)
NSP_27460Single-stranded-DNA-specific exonuclease RecJ; Nsp27460; ORF_ID:nsp27460. (727 aa)
NSP_28140Hypothetical protein; Nsp28140; ORF_ID:nsp28140. (607 aa)
NSP_30180Hypothetical protein; Nsp30180; ORF_ID:nsp30180. (182 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (225 aa)
NSP_31240Single-stranded-DNA-specific exonuclease RecJ; Nsp31240; ORF_ID:nsp31240. (780 aa)
recODNA recombination and repair protein RecO; Involved in DNA repair and RecF pathway recombination. (295 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (367 aa)
NSP_35730ATP binding protein; Nsp35730; ORF_ID:nsp35730. (423 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (524 aa)
NSP_36100Hypothetical protein; Nsp36100; ORF_ID:nsp36100. (52 aa)
NSP_36230Hypothetical protein; Nsp36230; ORF_ID:nsp36230. (134 aa)
NSP_36830Hypothetical protein; Nsp36830; ORF_ID:nsp36830. (265 aa)
NSP_37320Hypothetical protein; Nsp37320; ORF_ID:nsp37320. (418 aa)
NSP_37350Hypothetical protein; Nsp37350; ORF_ID:nsp37350. (541 aa)
NSP_380SMC domain protein; Nsp380; ORF_ID:nsp380. (437 aa)
NSP_40440Hypothetical protein; Nsp40440; ORF_ID:nsp40440. (201 aa)
NSP_40450Abortive infection protein, putative; Nsp40450; ORF_ID:nsp40450. (434 aa)
NSP_40750hupL element site-specific recombinase; Nsp40750; ORF_ID:nsp40750. (475 aa)
NSP_40790Integrase; Nsp40790; ORF_ID:nsp40790. (433 aa)
NSP_9870Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Nsp9870; ORF_ID:nsp9870. (151 aa)
NSP_41010hupL element site-specific recombinase; Nsp41010; ORF_ID:nsp41010. (488 aa)
NSP_42620Putative UV damage endonuclease; Nsp42620; ORF_ID:nsp42620. (315 aa)
NSP_43200ABC transport protein, ATP-binding subunit; Nsp43200; ORF_ID:nsp43200. (355 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (552 aa)
NSP_46520DNA adenine methylase; Nsp46520; ORF_ID:nsp46520. (312 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (163 aa)
NSP_4900DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (575 aa)
NSP_51050Hypothetical protein; Nsp51050; ORF_ID:nsp51050. (340 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (628 aa)
NSP_52010Radical SAM domain protein; Nsp52010; ORF_ID:nsp52010. (312 aa)
NSP_52670Hypothetical protein; Nsp52670; ORF_ID:nsp52670. (285 aa)
recFDNA recombination and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (376 aa)
NSP_53210Cell division protein Ftn6; Nsp53210; ORF_ID:nsp53210. (232 aa)
NSP_53320Hypothetical protein; Nsp53320; ORF_ID:nsp53320. (100 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (863 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (185 aa)
NSP_6900Helicase, C-terminal:Type III restriction enzyme, res subunit:DEAD/DEAH box helicase, N-terminal; Nsp6900; ORF_ID:nsp6900. (152 aa)
NSP_6910Helicase, C-terminal:Type III restriction enzyme, res subunit:DEAD/DEAH box helicase, N-terminal; Nsp6910; ORF_ID:nsp6910. (418 aa)
NSP_700Uracil-DNA glycosylase, family 4; Nsp700; ORF_ID:nsp700. (223 aa)
Your Current Organism:
Nodularia spumigena
NCBI taxonomy Id: 313624
Other names: N. spumigena CCY9414, Nodularia spumigena CCY9414
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