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| | dnaA | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (459 aa) |
| | NSP_10800 | Phosphate regulon transcriptional regulatory protein PhoB (SphR); Nsp10800; ORF_ID:nsp10800. (228 aa) |
| | NSP_10850 | Putative Transcriptional Regulator, Crp/Fnr family protein; Nsp10850; ORF_ID:nsp10850. (221 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (972 aa) |
| | NSP_11040 | RuBisCO operon transcriptional regulator; Nsp11040; ORF_ID:nsp11040; Belongs to the LysR transcriptional regulatory family. (337 aa) |
| | NSP_11600 | Hypothetical protein; Nsp11600; ORF_ID:nsp11600. (251 aa) |
| | NSP_11740 | Two-component response regulator; Nsp11740; ORF_ID:nsp11740. (238 aa) |
| | uvrA | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (956 aa) |
| | NSP_14280 | Cyanobacterial SigF-like sigma factor; Nsp14280; ORF_ID:nsp14280; Belongs to the sigma-70 factor family. (258 aa) |
| | NSP_14960 | Single-stranded DNA-binding protein; Nsp14960; ORF_ID:nsp14960. (178 aa) |
| | NSP_1570 | Two-component response regulator; Nsp1570; ORF_ID:nsp1570. (226 aa) |
| | NSP_15960 | RNA polymerase sigma-70 factor; Nsp15960; ORF_ID:nsp15960; Belongs to the sigma-70 factor family. ECF subfamily. (198 aa) |
| | NSP_16050 | Transcriptional regulator, TetR family; Nsp16050; ORF_ID:nsp16050. (211 aa) |
| | hetR | Main regulator of heterocyst differentiation HetR; Controls heterocyst differentiation. Has both a protease and a DNA-binding activity; Belongs to the peptidase S48 family. (280 aa) |
| | NSP_17120 | Cell division protein FtsK; Nsp17120; ORF_ID:nsp17120. (871 aa) |
| | NSP_17200 | Transcriptional regulator; Nsp17200; ORF_ID:nsp17200. (387 aa) |
| | NSP_17330 | Cold-shock DNA-binding domain protein; Nsp17330; ORF_ID:nsp17330. (209 aa) |
| | NSP_17610 | Cyanobacteria-specific RpoD-like sigma factor, type-3 Group 2 RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (327 aa) |
| | NSP_18040 | Nitrogen-responsive response regulator NrrA; Nsp18040; ORF_ID:nsp18040. (256 aa) |
| | NSP_18430 | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (264 aa) |
| | NSP_18940 | Two component Transcriptional regulator, Winged helix family protein; Nsp18940; ORF_ID:nsp18940. (228 aa) |
| | priA | Helicase PriA essential for oriC/DnaA-independent DNA replication; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (867 aa) |
| | NSP_19450 | Cyanobacteria-specific RpoD-like sigma factor, type-1; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (377 aa) |
| | NSP_19830 | DNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (100 aa) |
| | NSP_19890 | Peroxide stress regulator; Nsp19890; ORF_ID:nsp19890; Ferric uptake regulation protein; Fe2+/Zn2+ uptake regulation proteins; Belongs to the Fur family. (149 aa) |
| | NSP_20 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (387 aa) |
| | mutS2 | Recombination inhibitory protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (817 aa) |
| | NSP_20820 | Two-component response regulator; Nsp20820; ORF_ID:nsp20820. (231 aa) |
| | NSP_20950 | Two-component response regulator; Nsp20950; ORF_ID:nsp20950. (241 aa) |
| | recA | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (356 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (213 aa) |
| | NSP_22890 | Ferric uptake regulation protein FUR; Nsp22890; ORF_ID:nsp22890; Belongs to the Fur family. (151 aa) |
| | NSP_22910 | Group 2 RNA polymerase sigma factor Cyanobacteria-specific RpoD-like sigma factor, type-7; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (416 aa) |
| | lexA | SOS-response repressor and protease LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (208 aa) |
| | NSP_23770 | RNA polymerase sigma-70 factor; Nsp23770; ORF_ID:nsp23770; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1164 aa) |
| | NSP_25830 | Cyanobacterial SigF-like sigma factor; Nsp25830; ORF_ID:nsp25830; Belongs to the sigma-70 factor family. (254 aa) |
| | NSP_26020 | Two-component response regulator; Nsp26020; ORF_ID:nsp26020. (230 aa) |
| | NSP_2630 | Global nitrogen regulatory protein, CRP family of transcriptional regulators; Nsp2630; ORF_ID:nsp2630. (223 aa) |
| | NSP_2680 | Transcriptional regulator; Nsp2680; ORF_ID:nsp2680. (224 aa) |
| | NSP_2700 | Transcriptional regulator, AraC family; Nsp2700; ORF_ID:nsp2700. (347 aa) |
| | NSP_27080 | Putative DNA helicase; Nsp27080; ORF_ID:nsp27080. (711 aa) |
| | NSP_27280 | DNA-binding response regulator, LuxR family; Nsp27280; ORF_ID:nsp27280. (220 aa) |
| | NSP_2780 | Transcriptional regulator, AraC family; Nsp2780; ORF_ID:nsp2780. (73 aa) |
| | NSP_29540 | Transcriptional regulator, Crp/Fnr family; Nsp29540; ORF_ID:nsp29540. (219 aa) |
| | NSP_29800 | Nitrogen assimilation transcriptional activator NtcB; Nsp29800; ORF_ID:nsp29800; Belongs to the LysR transcriptional regulatory family. (189 aa) |
| | NSP_30280 | Single-stranded DNA-binding protein; Nsp30280; ORF_ID:nsp30280. (127 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (225 aa) |
| | NSP_33270 | DNA uptake protein and DNA-binding proteins; Nsp33270; ORF_ID:nsp33270. (176 aa) |
| | NSP_33590 | Two-component system response regulator; Nsp33590; ORF_ID:nsp33590. (230 aa) |
| | NSP_3380 | Transcriptional regulator, TetR family; Nsp3380; ORF_ID:nsp3380. (405 aa) |
| | cas1 | CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (336 aa) |
| | NSP_34180 | HicB protein; Nsp34180; ORF_ID:nsp34180. (109 aa) |
| | NSP_34730 | Two-component response regulator; Nsp34730; ORF_ID:nsp34730. (240 aa) |
| | NSP_35090 | LysR family transcriptional regulator YeiE; Nsp35090; ORF_ID:nsp35090; Belongs to the LysR transcriptional regulatory family. (291 aa) |
| | NSP_35750 | ATP-dependent DNA helicase UvrD/PcrA; Nsp35750; ORF_ID:nsp35750. (774 aa) |
| | NSP_36690 | DNA-binding response regulator, AraC family; Nsp36690; ORF_ID:nsp36690. (295 aa) |
| | NSP_39870 | Single-stranded DNA-binding protein; Nsp39870; ORF_ID:nsp39870. (120 aa) |
| | NSP_40380 | RuBisCO operon transcriptional regulator; Nsp40380; ORF_ID:nsp40380; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | NSP_4110 | Transcriptional regulator AbrB; Nsp4110; ORF_ID:nsp4110. (143 aa) |
| | NSP_42730 | Transcriptional regulator/antitoxin, MazE; Nsp42730; ORF_ID:nsp42730. (86 aa) |
| | NSP_44390 | Zinc uptake regulation protein ZUR; Nsp44390; ORF_ID:nsp44390; Belongs to the Fur family. (97 aa) |
| | kaiC | Circadian clock protein KaiC; Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction; Belongs to the KaiC family. (521 aa) |
| | NSP_45410 | Hypothetical protein; Nsp45410; ORF_ID:nsp45410. (236 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (861 aa) |
| | NSP_45750 | ATP-dependent DNA helicase UvrD/PcrA/Rep; Nsp45750; ORF_ID:nsp45750. (811 aa) |
| | NSP_45930 | Transcriptional regulator, TetR family; Nsp45930; ORF_ID:nsp45930. (201 aa) |
| | NSP_46500 | Phage integrase; Nsp46500; ORF_ID:nsp46500; Belongs to the 'phage' integrase family. (391 aa) |
| | NSP_46550 | Transcriptional regulator, TetR family; Nsp46550; ORF_ID:nsp46550. (190 aa) |
| | NSP_47140 | Chromosome (plasmid) partitioning protein ParB; Nsp47140; ORF_ID:nsp47140; Belongs to the ParB family. (538 aa) |
| | NSP_47300 | Transcriptional regulatory protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (101 aa) |
| | NSP_47320 | Two-component response regulator; Nsp47320; ORF_ID:nsp47320. (227 aa) |
| | NSP_47600 | AbrB family transciptional regulator; Nsp47600; ORF_ID:nsp47600. (137 aa) |
| | NSP_47880 | Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase; Nsp47880; ORF_ID:nsp47880; Belongs to the Dps family. (163 aa) |
| | NSP_48360 | Transcriptional regulator, FUR family; Nsp48360; ORF_ID:nsp48360; Belongs to the Fur family. (138 aa) |
| | NSP_48490 | Transcriptional regulator, GntR family; Nsp48490; ORF_ID:nsp48490. (328 aa) |
| | NSP_48880 | DNA gyrase subunit A; Nsp48880; ORF_ID:nsp48880. (836 aa) |
| | sigA | Group 2 RNA polymerase sigma factor RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (391 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (645 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (633 aa) |
| | NSP_51430 | Replicative DNA helicase intein-containing; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (451 aa) |
| | NSP_52090 | Two-component response regulator; Nsp52090; ORF_ID:nsp52090. (215 aa) |
| | NSP_52590 | DNA-binding response regulator, AraC family; Nsp52590; ORF_ID:nsp52590. (277 aa) |
| | recF | DNA recombination and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (376 aa) |
| | mutS | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (863 aa) |
| | NSP_53450 | Transcriptional regulator; Nsp53450; ORF_ID:nsp53450. (87 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (864 aa) |
| | NSP_6460 | Hypothetical protein; Nsp6460; ORF_ID:nsp6460. (109 aa) |
| | NSP_6500 | Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase; Nsp6500; ORF_ID:nsp6500; Belongs to the Dps family. (179 aa) |
| | NSP_7590 | Transcriptional regulator PhnF; Nsp7590; ORF_ID:nsp7590. (246 aa) |
| | NSP_8140 | Transcriptional regulator, TetR family; Nsp8140; ORF_ID:nsp8140. (204 aa) |
| | smc | Chromosome partition protein smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1206 aa) |
| | NSP_9010 | Putative transcriptional regulator of cysteine synthase, Rrf2 family; Nsp9010; ORF_ID:nsp9010. (145 aa) |
| | NSP_9840 | Cyanobacteria-specific RpoD-like sigma factor, type-2 Group 2 RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (318 aa) |
| | NSP_9940 | Putative transcriptional regulator ycf27; Nsp9940; ORF_ID:nsp9940. (242 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (524 aa) |
