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| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2,6- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (496 aa) |
| | lysS | Lysyl-tRNA synthetase (class II); Nsp10370; ORF_ID:nsp10370; Belongs to the class-II aminoacyl-tRNA synthetase family. (561 aa) |
| | NSP_1080 | Protoporphyrin IX Mg-chelatase subunit H; Nsp1080; ORF_ID:nsp1080. (1269 aa) |
| | argG | Argininosuccinate synthase; Nsp12880; ORF_ID:nsp12880; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa) |
| | leuS | Leucyl-tRNA synthetase; Nsp1300; ORF_ID:nsp1300; Belongs to the class-I aminoacyl-tRNA synthetase family. (873 aa) |
| | glyS | Glycyl-tRNA synthetase beta chain; Nsp13400; ORF_ID:nsp13400. (716 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (455 aa) |
| | glyQ | Glycyl-tRNA synthetase alpha chain; Nsp14040; ORF_ID:nsp14040. (292 aa) |
| | gshB | Glutathione synthetase; Nsp14350; ORF_ID:nsp14350; Belongs to the prokaryotic GSH synthase family. (322 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta chain; Nsp15080; ORF_ID:nsp15080; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (819 aa) |
| | NSP_15670 | Lipoate-protein ligase A; Nsp15670; ORF_ID:nsp15670. (262 aa) |
| | ligA | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (678 aa) |
| | NSP_16180 | Glutamine synthetase type I; Nsp16180; ORF_ID:nsp16180. (471 aa) |
| | NSP_16290 | Protoporphyrin IX Mg-chelatase subunit I; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (348 aa) |
| | hisS | Histidyl-tRNA synthetase; Nsp16520; ORF_ID:nsp16520. (462 aa) |
| | NSP_16660 | 2'-5' RNA ligase; Nsp16660; ORF_ID:nsp16660. (195 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (939 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | NSP_19070 | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenoylcysteine synthetase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (417 aa) |
| | NSP_19160 | RNA 3'-terminal phosphate cyclase; Nsp19160; ORF_ID:nsp19160. (62 aa) |
| | cysS | Cysteinyl-tRNA synthetase; Nsp19600; ORF_ID:nsp19600; Belongs to the class-I aminoacyl-tRNA synthetase family. (477 aa) |
| | NSP_19760 | Dihydrofolate synthase / Folylpolyglutamate synthase; Nsp19760; ORF_ID:nsp19760; Belongs to the folylpolyglutamate synthase family. (448 aa) |
| | gltX | Glutamyl-tRNA synthetase Glutamyl-tRNA(Gln) synthetase unambiguous; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (481 aa) |
| | NSP_23020 | D-alanine--D-alanine ligase; Nsp23020; ORF_ID:nsp23020. (350 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa) |
| | nadE | NAD synthetase/ Glutamine amidotransferase chain of NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (573 aa) |
| | queC | Queuosine Biosynthesis QueC ATPase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (236 aa) |
| | NSP_25820 | Protoporphyrin IX Mg-chelatase subunit D; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (680 aa) |
| | NSP_26320 | Long-chain-fatty-acid--CoA ligase; Nsp26320; ORF_ID:nsp26320. (500 aa) |
| | NSP_26730 | Long-chain-fatty-acid--CoA ligase; Nsp26730; ORF_ID:nsp26730. (1205 aa) |
| | NSP_26910 | Long-chain-fatty-acid--CoA ligase; Nsp26910; ORF_ID:nsp26910. (1650 aa) |
| | NSP_26920 | Long-chain-fatty-acid--CoA ligase; Nsp26920; ORF_ID:nsp26920. (2595 aa) |
| | NSP_26930 | Long-chain-fatty-acid--CoA ligase; Nsp26930; ORF_ID:nsp26930. (1077 aa) |
| | NSP_26950 | Long-chain-fatty-acid--CoA ligase; Nsp26950; ORF_ID:nsp26950. (2436 aa) |
| | NSP_26960 | Long-chain-fatty-acid--CoA ligase; Nsp26960; ORF_ID:nsp26960. (2621 aa) |
| | NSP_26980 | Long-chain-fatty-acid--CoA ligase; Nsp26980; ORF_ID:nsp26980. (1088 aa) |
| | NSP_270 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (465 aa) |
| | NSP_29090 | Methionyl-tRNA synthetase; Nsp29090; ORF_ID:nsp29090. (226 aa) |
| | NSP_29100 | Methionyl-tRNA synthetase; Nsp29100; ORF_ID:nsp29100; Belongs to the class-I aminoacyl-tRNA synthetase family. (309 aa) |
| | NSP_29380 | Biotin-protein ligase; Nsp29380; ORF_ID:nsp29380. (232 aa) |
| | NSP_29570 | 5-formyltetrahydrofolate cyclo-ligase; Nsp29570; ORF_ID:nsp29570; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (165 aa) |
| | NSP_3040 | Acetyl-coenzyme A carboxyl transferase alpha chain; Nsp3040; ORF_ID:nsp3040. (178 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (455 aa) |
| | NSP_31360 | Putative amino acid ligase found clustered with an amidotransferase; Nsp31360; ORF_ID:nsp31360. (429 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (224 aa) |
| | panC/cmk | Pantoate--beta-alanine ligase / Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the N-terminal section; belongs to the pantothenate synthetase family. (534 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; Nsp31670; ORF_ID:nsp31670. (342 aa) |
| | NSP_3360 | Long-chain-fatty-acid--CoA ligase; Nsp3360; ORF_ID:nsp3360. (635 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (355 aa) |
| | NSP_35900 | Glutamate--cysteine ligase, putative; Nsp35900; ORF_ID:nsp35900. (379 aa) |
| | argS | Arginyl-tRNA synthetase; Nsp36250; ORF_ID:nsp36250. (588 aa) |
| | NSP_3680 | Long-chain-fatty-acid--CoA ligase; Nsp3680; ORF_ID:nsp3680. (658 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (402 aa) |
| | NSP_37170 | Biotin carboxylase; Nsp37170; ORF_ID:nsp37170. (123 aa) |
| | alaS | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (887 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Nsp38260; ORF_ID:nsp38260; Belongs to the GARS family. (425 aa) |
| | NSP_38640 | Cyanophycin synthase; Nsp38640; ORF_ID:nsp38640. (636 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Nsp39230; ORF_ID:nsp39230; Belongs to the CarA family. (368 aa) |
| | gatC | Aspartyl-tRNA(Asn) amidotransferase subunit C Glutamyl-tRNA(Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (97 aa) |
| | NSP_4190 | Biotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | NSP_42140 | Long-chain-fatty-acid--CoA ligase; Nsp42140; ORF_ID:nsp42140. (2607 aa) |
| | tilS | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (333 aa) |
| | pheS | Phenylalanyl-tRNA synthetase alpha chain; Nsp42850; ORF_ID:nsp42850; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (330 aa) |
| | accD | Acetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (316 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Nsp44030; ORF_ID:nsp44030; Belongs to the SAICAR synthetase family. (221 aa) |
| | thrS | Threonyl-tRNA synthetase; Nsp44240; ORF_ID:nsp44240; Belongs to the class-II aminoacyl-tRNA synthetase family. (572 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ a [...] (224 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, PurS subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (92 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (419 aa) |
| | NSP_45540 | GMP synthase [glutamine-hydrolyzing]; Nsp45540; ORF_ID:nsp45540. (275 aa) |
| | NSP_46820 | Protoporphyrin IX Mg-chelatase subunit H; Nsp46820; ORF_ID:nsp46820. (1249 aa) |
| | NSP_47000 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; Nsp47000; ORF_ID:nsp47000. (929 aa) |
| | proS | Prolyl-tRNA synthetase Bacterial type; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing a [...] (602 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (495 aa) |
| | NSP_48220 | O-succinylbenzoic acid--CoA ligase; Nsp48220; ORF_ID:nsp48220. (463 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (539 aa) |
| | NSP_49230 | Long-chain-fatty-acid--CoA ligase; Nsp49230; ORF_ID:nsp49230. (4171 aa) |
| | NSP_49250 | Long-chain-fatty-acid--CoA ligase; Nsp49250; ORF_ID:nsp49250. (1142 aa) |
| | NSP_49350 | Long-chain-fatty-acid--CoA ligase; Nsp49350; ORF_ID:nsp49350. (2195 aa) |
| | NSP_49360 | Long-chain-fatty-acid--CoA ligase; Nsp49360; ORF_ID:nsp49360. (1075 aa) |
| | NSP_49370 | Long-chain-fatty-acid--CoA ligase; Nsp49370; ORF_ID:nsp49370. (2558 aa) |
| | NSP_49380 | Long-chain-fatty-acid--CoA ligase; Nsp49380; ORF_ID:nsp49380. (1394 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (1010 aa) |
| | NSP_49630 | Putative cytoplasmic protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (391 aa) |
| | NSP_50060 | Asparagine synthetase [glutamine-hydrolyzing]; Nsp50060; ORF_ID:nsp50060. (643 aa) |
| | cbiA | Cobyrinic acid A,C-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (463 aa) |
| | NSP_50530 | Long-chain-fatty-acid--CoA ligase; Nsp50530; ORF_ID:nsp50530. (1490 aa) |
| | NSP_50540 | Long-chain-fatty-acid--CoA ligase; Nsp50540; ORF_ID:nsp50540; Belongs to the ATP-dependent AMP-binding enzyme family. (1518 aa) |
| | NSP_50580 | Long-chain-fatty-acid--CoA ligase; Nsp50580; ORF_ID:nsp50580. (1090 aa) |
| | trpS | Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (336 aa) |
| | asnS | Asparaginyl-tRNA synthetase; Nsp52120; ORF_ID:nsp52120. (463 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase, synthetase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (793 aa) |
| | gatB | Aspartyl-tRNA(Asn) amidotransferase subunit B Glutamyl-tRNA(Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (491 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (450 aa) |
| | aspS | Aspartyl-tRNA synthetase Aspartyl-tRNA(Asn) synthetase unambiguous; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (576 aa) |
| | NSP_5980 | Succinyl-CoA ligase [ADP-forming] beta chain; Nsp5980; ORF_ID:nsp5980. (408 aa) |
| | NSP_5990 | Succinyl-CoA ligase [ADP-forming] alpha chain; Nsp5990; ORF_ID:nsp5990. (299 aa) |
| | NSP_6920 | Asparagine synthetase [glutamine-hydrolyzing]; Nsp6920; ORF_ID:nsp6920. (476 aa) |
| | gatA | Aspartyl-tRNA(Asn) amidotransferase subunit A Glutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (485 aa) |
| | NSP_7040 | glutamyl-tRNA amidotransferase subunit A; Nsp7040; ORF_ID:nsp7040. (46 aa) |
| | accA | Acetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (326 aa) |
| | tyrS | Tyrosyl-tRNA synthetase cluster 1; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (431 aa) |
| | NSP_9120 | Dethiobiotin synthetase; Nsp9120; ORF_ID:nsp9120. (122 aa) |
| | NSP_9670 | Cyanophycin synthase; Nsp9670; ORF_ID:nsp9670. (824 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Nsp9830; ORF_ID:nsp9830; Belongs to the CarB family. (1088 aa) |
