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| | EDM27746.1 | Asparagine synthetase (WbpS); COG0367 Asparagine synthase (glutamine-hydrolyzing). (643 aa) |
| | cls | Cardiolipin synthetase. (607 aa) |
| | aspS-2 | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (596 aa) |
| | EDM27884.1 | COG0439 Biotin carboxylase. (545 aa) |
| | carA | COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (386 aa) |
| | EDM26543.1 | Hypothetical protein. (148 aa) |
| | EDM26569.1 | UBA/THIF-type NAD/FAD binding fold protein; COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1. (263 aa) |
| | atpC | ATP synthase, F1 epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (85 aa) |
| | EDM24735.1 | COG0055 F0F1-type ATP synthase, beta subunit. (270 aa) |
| | EDM24736.1 | COG0055 F0F1-type ATP synthase, beta subunit. (161 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (289 aa) |
| | atpA | ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (521 aa) |
| | atpH | ATP synthase delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (179 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (190 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (89 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (283 aa) |
| | gshA | Glutamate--cysteine ligase; COG2918 Gamma-glutamylcysteine synthetase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (514 aa) |
| | EDM24958.1 | Hypothetical protein; COG3307 Lipid A core - O-antigen ligase and related enzymes. (634 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (372 aa) |
| | EDM25227.1 | COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (348 aa) |
| | EDM25334.1 | Hypothetical protein; COG1240 Mg-chelatase subunit ChlD. (332 aa) |
| | EDM25335.1 | COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (307 aa) |
| | EDM24672.1 | COG0008 Glutamyl- and glutaminyl-tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. (217 aa) |
| | EDM24793.1 | COG0008 Glutamyl- and glutaminyl-tRNA synthetases. (123 aa) |
| | aspS-3 | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (591 aa) |
| | EDM26083.1 | Hypothetical protein. (409 aa) |
| | rtcA | RNA 3'-terminal-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (338 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (997 aa) |
| | EDM26108.1 | COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain. (268 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (226 aa) |
| | accD | acetyl-coA carboxylase carboxyl transferase subunit beta/alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa) |
| | EDM27436.1 | COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (583 aa) |
| | EDM27532.1 | BatB; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (718 aa) |
| | EDM27533.1 | BatA; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (341 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (577 aa) |
| | EDM26457.1 | Phosphoribosylformylglycinamidine cyclo-ligase, putative; COG0150 Phosphoribosylaminoimidazole (AIR) synthetase. (394 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa) |
| | gatC | glutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (96 aa) |
| | gatA | glutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (488 aa) |
| | gatB | aspartyl/glutamyl-tRNA amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (489 aa) |
| | EDM25601.1 | BirA bifunctional protein; COG0340 Biotin-(acetyl-CoA carboxylase) ligase. (245 aa) |
| | EDM25069.1 | Peptide synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (549 aa) |
| | thrS | COG0441 Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (603 aa) |
| | EDM25076.1 | Putative acyl-CoA synthetase, long-chain-fatty acid:CoA ligase; COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (579 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (424 aa) |
| | carB-2 | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (1079 aa) |
| | EDM28551.1 | COG4067 Uncharacterized protein conserved in archaea. (288 aa) |
| | EDM28553.1 | Alpha-L-glutamate ligase-related protein; COG4992 Ornithine/acetylornithine aminotransferase. (316 aa) |
| | EDM28005.1 | Hypothetical protein. (358 aa) |
| | EDM28030.1 | Hypothetical protein; COG3307 Lipid A core - O-antigen ligase and related enzymes. (470 aa) |
| | EDM28129.1 | MoeZ/MoeB; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. (249 aa) |
| | lysS | COG1190 Lysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (492 aa) |
| | EDM25710.1 | COG0367 Asparagine synthase (glutamine-hydrolyzing). (519 aa) |
| | hisS | COG0124 Histidyl-tRNA synthetase. (435 aa) |
| | EDM28845.1 | Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase. (201 aa) |
| | EDM28879.1 | Possible ribosomal protein S6 modification protein; COG4067 Uncharacterized protein conserved in archaea. (459 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1042 aa) |
| | EDM29069.1 | Hypothetical protein; COG0212 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (181 aa) |
| | purD | COG0151 Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (420 aa) |
| | cysS | COG0215 Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (463 aa) |
| | purC-2 | COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (365 aa) |
| | EDM29122.1 | COG0773 UDP-N-acetylmuramate-alanine ligase. (458 aa) |
| | EDM25791.1 | Von Willebrand factor, type A; COG4547 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase). (512 aa) |
| | EDM27106.1 | Hypothetical protein. (705 aa) |
| | argS | COG0018 Arginyl-tRNA synthetase. (587 aa) |
| | EDM27165.1 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1151 aa) |
| | EDM27191.1 | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (423 aa) |
| | EDM27209.1 | UDP-N-acetylmuramyl pentapeptide synthase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. (455 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (472 aa) |
| | EDM27231.1 | Hypothetical protein; COG3307 Lipid A core - O-antigen ligase and related enzymes. (730 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (485 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (536 aa) |
| | EDM29738.1 | Hypothetical protein. (613 aa) |
| | leuS-2 | COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (873 aa) |
| | EDM26687.1 | Glutamine synthetase, type III; COG3968 Uncharacterized protein related to glutamine synthetase. (726 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (437 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | EDM26755.1 | Long-chain fatty-acid-CoA ligase; COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (562 aa) |
| | pheS | COG0016 Phenylalanyl-tRNA synthetase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (340 aa) |
| | EDM26359.1 | COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase. (219 aa) |
| | EDM26360.1 | COG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (411 aa) |
| | EDM26380.1 | COG0272 NAD-dependent DNA ligase (contains BRCT domain type II). (647 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (426 aa) |
| | EDM27616.1 | Glutamate--tRNA ligase; COG0008 Glutamyl- and glutaminyl-tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. (274 aa) |
| | trpS | Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (333 aa) |
| | panC | Pantoate-beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa) |
| | acsA | Acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (652 aa) |
| | sucC | succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa) |
| | sucD | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa) |
| | EDM25361.1 | COG0525 Valyl-tRNA synthetase. (913 aa) |
| | asnC | COG0017 Aspartyl/asparaginyl-tRNA synthetases. (459 aa) |
| | EDM29383.1 | Hypothetical protein; COG0457 FOG: TPR repeat. (807 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (899 aa) |
| | EDM29388.1 | acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (144 aa) |
| | bioD | Dethiobiotin synthetase (bioD); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (233 aa) |
| | EDM25507.1 | COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (333 aa) |
| | EDM25508.1 | COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (316 aa) |
| | EDM25524.1 | lysyl-tRNA synthetase-related protein; COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II). (292 aa) |
| | EDM26229.1 | COG1488 Nicotinic acid phosphoribosyltransferase. (428 aa) |
| | EDM26286.1 | Hypothetical protein; COG3307 Lipid A core - O-antigen ligase and related enzymes. (859 aa) |
| | gshB | COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Belongs to the prokaryotic GSH synthase family. (329 aa) |
| | EDM24681.1 | COG0172 Seryl-tRNA synthetase. (260 aa) |
