(54 nodes) Porphyrin and chlorophyll metabolism network (Lentisphaera araneosa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	EDM28316.1	Cobalamin (vitamin B12) biosynthesis CbiX protein. (139 aa)
	EDM25334.1	Hypothetical protein; COG1240 Mg-chelatase subunit ChlD. (332 aa)
	EDM25335.1	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (307 aa)
	EDM25338.1	ATPase, AAA family protein; COG0714 MoxR-like ATPases. (345 aa)
	hemF	Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (304 aa)
	EDM26113.1	uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (229 aa)
	EDM27436.1	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (583 aa)
	EDM27438.1	Hypothetical protein; COG0714 MoxR-like ATPases. (331 aa)
	EDM27459.1	COG1492 Cobyric acid synthase. (107 aa)
	cobQ	Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (338 aa)
	hemL	Glutamate-1-semialdehyde-2,1-aminomutase; COG0001 Glutamate-1-semialdehyde aminotransferase. (423 aa)
	hemE	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (343 aa)
	EDM27504.1	cob(I)yrinic acid a,c-diamide adenosyltransferase; COG2109 ATP:corrinoid adenosyltransferase. (201 aa)
	EDM27532.1	BatB; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (718 aa)
	EDM27533.1	BatA; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (341 aa)
	EDM27536.1	ATPase family associated with various cellular activities (AAA), putative; COG0714 MoxR-like ATPases. (328 aa)
	EDM28400.1	COG1032 Fe-S oxidoreductase. (529 aa)
	EDM28549.1	Radical SAM; COG1032 Fe-S oxidoreductase. (731 aa)
	EDM28170.1	Hypothetical methyltransferase; COG1032 Fe-S oxidoreductase. (437 aa)
	EDM28981.1	Methanol dehydrogenase regulatory protein; COG0714 MoxR-like ATPases. (313 aa)
	tig	Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (445 aa)
	EDM25791.1	Von Willebrand factor, type A; COG4547 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase). (512 aa)
	EDM25793.1	ATPase; COG0714 MoxR-like ATPases. (326 aa)
	EDM27106.1	Hypothetical protein. (705 aa)
	EDM27108.1	ATPase, AAA family protein; COG0714 MoxR-like ATPases. (337 aa)
	EDM26154.1	Hypothetical protein; COG0714 MoxR-like ATPases. (509 aa)
	EDM29416.1	Bifunctional cobalamin biosynthesis protein (CobP)-like protein; COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase. (179 aa)
	EDM29417.1	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (345 aa)
	cls	Cardiolipin synthetase. (607 aa)
	EDM27905.1	ATPase, AAA family protein; COG0714 MoxR-like ATPases. (337 aa)
	EDM27960.1	MoxR protein; COG1716 FOG: FHA domain. (429 aa)
	cobS	Hypothetical protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (254 aa)
	EDM27963.1	COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (328 aa)
	EDM27992.1	Glutamate-1-semialdehyde-2,1-aminomutase; COG0001 Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (438 aa)
	EDM25819.1	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (455 aa)
	hemA	glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (414 aa)
	hemC	Prolyl 4-hydroxylase, alpha subunit; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (307 aa)
	EDM25835.1	Hypothetical protein; COG0714 MoxR-like ATPases. (354 aa)
	EDM26636.1	Hypothetical protein; COG0419 ATPase involved in DNA repair. (1734 aa)
	EDM25224.1	moxR-type regulator; COG0714 MoxR-like ATPases. (339 aa)
	EDM25227.1	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (348 aa)
	EDM25311.1	Hypothetical protein; COG0500 SAM-dependent methyltransferases. (383 aa)
	EDM29699.1	Hypothetical protein; COG0535 Predicted Fe-S oxidoreductases. (294 aa)
	EDM29738.1	Hypothetical protein. (613 aa)
	map	Hypothetical protein; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (256 aa)
	EDM26343.1	Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (375 aa)
	EDM27600.1	Putative cytochrome aa3 oxidase assembly protein, putative CtaA; COG1612 Uncharacterized protein required for cytochrome oxidase assembly. (342 aa)
	ctaB	Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (299 aa)
	EDM27603.1	Hypothetical protein; COG2813 16S RNA G1207 methylase RsmC; Belongs to the methyltransferase superfamily. (378 aa)
	EDM27692.1	Probable uroporphiryn-III C-methyltransferase/siroheme synthase; COG0007 Uroporphyrinogen-III methylase. (460 aa)
	EDM25504.1	COG0714 MoxR-like ATPases. (322 aa)
	EDM25507.1	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (333 aa)
	EDM25508.1	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (316 aa)
	EDM25152.1	Ferritin; Iron-storage protein. (180 aa)

Your Current Organism:

Lentisphaera araneosa

NCBI taxonomy Id: 313628
Other names: L. araneosa HTCC2155, Lentisphaera araneosa HTCC2155, Lentisphaera araneosa str. HTCC2155, Lentisphaera araneosa strain HTCC2155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDM25224.1	EDM25227.1	LNTAR_03309	LNTAR_03324	moxR-type regulator; COG0714 MoxR-like ATPases.	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	0.862
EDM25224.1	EDM27532.1	LNTAR_03309	LNTAR_05451	moxR-type regulator; COG0714 MoxR-like ATPases.	BatB; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	0.464
EDM25224.1	EDM27533.1	LNTAR_03309	LNTAR_05456	moxR-type regulator; COG0714 MoxR-like ATPases.	BatA; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	0.424
EDM25227.1	EDM25224.1	LNTAR_03324	LNTAR_03309	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	moxR-type regulator; COG0714 MoxR-like ATPases.	0.862
EDM25227.1	EDM25508.1	LNTAR_03324	LNTAR_23604	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	0.776
EDM25311.1	EDM26113.1	LNTAR_03499	LNTAR_04666	Hypothetical protein; COG0500 SAM-dependent methyltransferases.	uroporphyrinogen-III synthetase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.	0.546
EDM25311.1	EDM27692.1	LNTAR_03499	LNTAR_20838	Hypothetical protein; COG0500 SAM-dependent methyltransferases.	Probable uroporphiryn-III C-methyltransferase/siroheme synthase; COG0007 Uroporphyrinogen-III methylase.	0.477
EDM25311.1	EDM28316.1	LNTAR_03499	LNTAR_10386	Hypothetical protein; COG0500 SAM-dependent methyltransferases.	Cobalamin (vitamin B12) biosynthesis CbiX protein.	0.623
EDM25334.1	EDM25335.1	LNTAR_03614	LNTAR_03619	Hypothetical protein; COG1240 Mg-chelatase subunit ChlD.	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	0.773
EDM25334.1	EDM25338.1	LNTAR_03614	LNTAR_03634	Hypothetical protein; COG1240 Mg-chelatase subunit ChlD.	ATPase, AAA family protein; COG0714 MoxR-like ATPases.	0.778
EDM25335.1	EDM25334.1	LNTAR_03619	LNTAR_03614	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	Hypothetical protein; COG1240 Mg-chelatase subunit ChlD.	0.773
EDM25335.1	EDM25338.1	LNTAR_03619	LNTAR_03634	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	ATPase, AAA family protein; COG0714 MoxR-like ATPases.	0.778
EDM25335.1	EDM25508.1	LNTAR_03619	LNTAR_23604	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	0.774
EDM25335.1	EDM27532.1	LNTAR_03619	LNTAR_05451	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	BatB; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	0.773
EDM25338.1	EDM25334.1	LNTAR_03634	LNTAR_03614	ATPase, AAA family protein; COG0714 MoxR-like ATPases.	Hypothetical protein; COG1240 Mg-chelatase subunit ChlD.	0.778
EDM25338.1	EDM25335.1	LNTAR_03634	LNTAR_03619	ATPase, AAA family protein; COG0714 MoxR-like ATPases.	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	0.778
EDM25504.1	EDM25507.1	LNTAR_23584	LNTAR_23599	COG0714 MoxR-like ATPases.	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	0.882
EDM25504.1	EDM25508.1	LNTAR_23584	LNTAR_23604	COG0714 MoxR-like ATPases.	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	0.880
EDM25507.1	EDM25504.1	LNTAR_23599	LNTAR_23584	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	COG0714 MoxR-like ATPases.	0.882
EDM25507.1	EDM25508.1	LNTAR_23599	LNTAR_23604	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain.	0.990

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