STRINGSTRING
EDM27876.1 EDM27876.1 EDM27883.1 EDM27883.1 EDM27884.1 EDM27884.1 pckA pckA EDM25040.1 EDM25040.1 EDM26530.1 EDM26530.1 EDM26606.1 EDM26606.1 EDM24686.1 EDM24686.1 EDM24946.1 EDM24946.1 ppc ppc EDM26067.1 EDM26067.1 pgk-2 pgk-2 accD accD glyA-2 glyA-2 EDM26461.1 EDM26461.1 EDM26477.1 EDM26477.1 accA accA vapC vapC EDM26973.1 EDM26973.1 EDM24967.1 EDM24967.1 EDM24972.1 EDM24972.1 EDM25579.1 EDM25579.1 EDM25591.1 EDM25591.1 pfp pfp EDM28621.1 EDM28621.1 pgi pgi EDM25070.1 EDM25070.1 EDM25077.1 EDM25077.1 tpiA tpiA EDM28359.1 EDM28359.1 pfp-2 pfp-2 EDM28378.1 EDM28378.1 EDM28486.1 EDM28486.1 vapC-2 vapC-2 EDM28189.1 EDM28189.1 sdhA sdhA EDM28191.1 EDM28191.1 zwf zwf EDM25727.1 EDM25727.1 EDM25736.1 EDM25736.1 EDM28873.1 EDM28873.1 EDM28896.1 EDM28896.1 EDM28930.1 EDM28930.1 tal tal EDM24826.1 EDM24826.1 EDM27085.1 EDM27085.1 EDM27165.1 EDM27165.1 EDM27188.1 EDM27188.1 EDM29422.1 EDM29422.1 gcvH gcvH EDM29661.1 EDM29661.1 EDM29662.1 EDM29662.1 ilvA ilvA EDM29679.1 EDM29679.1 EDM26734.1 EDM26734.1 EDM26747.1 EDM26747.1 eno eno EDM27586.1 EDM27586.1 EDM27588.1 EDM27588.1 EDM27589.1 EDM27589.1 EDM27695.1 EDM27695.1 kgd kgd sucC sucC sucD sucD EDM25371.1 EDM25371.1 folD folD EDM29375.1 EDM29375.1 EDM29388.1 EDM29388.1 EDM26214.1 EDM26214.1 EDM26262.1 EDM26262.1 EDM26267.1 EDM26267.1 EDM26285.1 EDM26285.1 EDM25629.1 EDM25629.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDM27876.1COG0281 Malic enzyme. (459 aa)
EDM27883.1COG0021 Transketolase; Belongs to the transketolase family. (657 aa)
EDM27884.1COG0439 Biotin carboxylase. (545 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (503 aa)
EDM25040.16-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (482 aa)
EDM26530.1Aldolase; COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. (290 aa)
EDM26606.1Carbohydrate kinase, thermoresistant glucokinase family protein; COG3265 Gluconate kinase. (159 aa)
EDM24686.1PIN domain protein; COG1487 Predicted nucleic acid-binding protein, contains PIN domain. (127 aa)
EDM24946.1COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (442 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (882 aa)
EDM26067.1Transcriptional regulator, XRE family protein; COG0560 Phosphoserine phosphatase. (223 aa)
pgk-2COG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
accDacetyl-coA carboxylase carboxyl transferase subunit beta/alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (504 aa)
EDM26461.1COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. (206 aa)
EDM26477.1COG1062 Zn-dependent alcohol dehydrogenases, class III. (369 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa)
vapCVirulence associated protein C; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (133 aa)
EDM26973.1Hypothetical protein; COG2706 3-carboxymuconate cyclase. (370 aa)
EDM24967.1Putative transcriptional regulator, rpiR family protein; COG1737 Transcriptional regulators. (262 aa)
EDM24972.1KDPG and KHG aldolase; COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. (205 aa)
EDM25579.1Aconitate hydratase 2; COG1049 Aconitase B; Belongs to the aconitase/IPM isomerase family. (853 aa)
EDM25591.1COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
pfpDiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (408 aa)
EDM28621.1Putative oxidoreductase protein; COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (695 aa)
pgiCOG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family. (526 aa)
EDM25070.1Ribose-phosphate pyrophosphokinase; COG0462 Phosphoribosylpyrophosphate synthetase. (390 aa)
EDM25077.13-hydroxyacyl-CoA dehydrogenase, C-terminal domain family protein; COG1250 3-hydroxyacyl-CoA dehydrogenase. (762 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (256 aa)
EDM28359.1Hypothetical protein; COG2706 3-carboxymuconate cyclase. (368 aa)
pfp-2Diphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (546 aa)
EDM28378.1Glutathione-dependent formaldehyde-activating, GFA. (140 aa)
EDM28486.1Hypothetical protein; COG2706 3-carboxymuconate cyclase. (354 aa)
vapC-2PilT protein-like protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (129 aa)
EDM28189.1COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. (256 aa)
sdhACOG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (644 aa)
EDM28191.1Putative cytochrome B subunit; COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. (241 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (475 aa)
EDM25727.1Hypothetical protein; COG2706 3-carboxymuconate cyclase. (356 aa)
EDM25736.1COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (736 aa)
EDM28873.1Cobyrinic acid a,c-diamide synthase family protein; COG0857 BioD-like N-terminal domain of phosphotransacetylase. (364 aa)
EDM28896.1COG1393 Arsenate reductase and related proteins, glutaredoxin family; Belongs to the ArsC family. (119 aa)
EDM28930.1COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (485 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (318 aa)
EDM24826.1PIN domain protein; COG1487 Predicted nucleic acid-binding protein, contains PIN domain. (126 aa)
EDM27085.1COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (220 aa)
EDM27165.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1151 aa)
EDM27188.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
EDM29422.1Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (371 aa)
gcvHGlycine cleavage H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (120 aa)
EDM29661.1COG0560 Phosphoserine phosphatase. (295 aa)
EDM29662.1COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (350 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (512 aa)
EDM29679.1COG0372 Citrate synthase; Belongs to the citrate synthase family. (417 aa)
EDM26734.1COG2833 Uncharacterized protein conserved in bacteria. (650 aa)
EDM26747.1LD-carboxypeptidase family protein; COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF. (289 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
EDM27586.1COG0698 Ribose 5-phosphate isomerase RpiB. (145 aa)
EDM27588.1COG1045 Serine acetyltransferase. (257 aa)
EDM27589.1COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
EDM27695.1Dihydrolipoamide acetyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (415 aa)
kgdAlpha-ketoglutarate decarboxylase; COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (913 aa)
sucCsuccinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
EDM25371.1Pyruvate phosphate dikinase; COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (933 aa)
folDMethylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
EDM29375.1COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain. (993 aa)
EDM29388.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (144 aa)
EDM26214.1Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (547 aa)
EDM26262.1Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (537 aa)
EDM26267.15,10-methylenetetrahydrofolate reductase-related protein; COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (255 aa)
EDM26285.1COG0685 5,10-methylenetetrahydrofolate reductase. (487 aa)
EDM25629.1Hypothetical protein. (272 aa)
Your Current Organism:
Lentisphaera araneosa
NCBI taxonomy Id: 313628
Other names: L. araneosa HTCC2155, Lentisphaera araneosa HTCC2155, Lentisphaera araneosa str. HTCC2155, Lentisphaera araneosa strain HTCC2155
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