STRINGSTRING
EAU47586.1 EAU47586.1 EAU44334.1 EAU44334.1 parE parE EAU45692.1 EAU45692.1 EAU46370.1 EAU46370.1 EAU46378.1 EAU46378.1 EAU45208.1 EAU45208.1 priA priA parC parC EAU44097.1 EAU44097.1 EAU44117.1 EAU44117.1 gyrB gyrB EAU48273.1 EAU48273.1 ruvA ruvA ruvB ruvB topA topA EAU45085.1 EAU45085.1 EAU43573.1 EAU43573.1 EAU44635.1 EAU44635.1 EAU46223.1 EAU46223.1 gyrA gyrA EAU44201.1 EAU44201.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EAU47586.1Hypothetical protein; COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster. (2003 aa)
EAU44334.1Nickase; COG3843 Type IV secretory pathway, VirD2 components (relaxase). (393 aa)
parEDNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (652 aa)
EAU45692.1Hypothetical protein; COG0606 Predicted ATPase with chaperone activity. (434 aa)
EAU46370.1Competence protein ComM; COG0606 Predicted ATPase with chaperone activity. (504 aa)
EAU46378.1Putative DNA topoisomerase I protein; COG3569 Topoisomerase IB. (328 aa)
EAU45208.1Hypothetical protein. (309 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (729 aa)
parCDNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (807 aa)
EAU44097.1COG0514 Superfamily II DNA helicase. (684 aa)
EAU44117.1COG0210 Superfamily I DNA and RNA helicases. (680 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (805 aa)
EAU48273.1ATP-dependent DNA helicase, UvrD/Rep family protein; COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); Belongs to the helicase family. UvrD subfamily. (1125 aa)
ruvAHolliday junction DNA helicase motor protein; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (224 aa)
ruvBHolliday junction DNA helicase B; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (341 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (906 aa)
EAU45085.1Hypothetical protein; COG3378 Predicted ATPase. (605 aa)
EAU43573.1COG1200 RecG-like helicase. (696 aa)
EAU44635.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (494 aa)
EAU46223.1Hypothetical protein; COG0433 Predicted ATPase. (527 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (905 aa)
EAU44201.1COG0210 Superfamily I DNA and RNA helicases. (816 aa)
Your Current Organism:
Salipiger bermudensis
NCBI taxonomy Id: 314265
Other names: Pelagibaca bermudensis HTCC2601, Pelagibaca bermudensis str. HTCC2601, Pelagibaca bermudensis strain HTCC2601, Roseovarius sp. HTCC2601, S. bermudensis HTCC2601, Salipiger bermudensis HTCC2601
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