STRINGSTRING
EAS47181.1 EAS47181.1 pyrG pyrG carB carB carA carA nrdR nrdR EAS48101.1 EAS48101.1 thyA thyA pyrE pyrE EAS47969.1 EAS47969.1 EAS47965.1 EAS47965.1 ppnP ppnP EAS47903.1 EAS47903.1 EAS47902.1 EAS47902.1 EAS47749.1 EAS47749.1 ndk ndk dcd dcd pyrC pyrC EAS46202.1 EAS46202.1 cmk cmk EAS46885.1 EAS46885.1 EAS46873.1 EAS46873.1 EAS46811.1 EAS46811.1 EAS46796.1 EAS46796.1 EAS46795.1 EAS46795.1 pyrF pyrF tgt tgt EAS46634.1 EAS46634.1 EAS47509.1 EAS47509.1 EAS47453.1 EAS47453.1 tmk tmk pyrH pyrH rlmL rlmL EAS46140.1 EAS46140.1 groS groS EAS47307.1 EAS47307.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EAS47181.1Short chain dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (270 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (547 aa)
carBCOG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (1072 aa)
carACOG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (380 aa)
nrdRHypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (157 aa)
EAS48101.1Putative membrane protein; COG2211 Na+/melibiose symporter and related transporters. (483 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (301 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (220 aa)
EAS47969.1Probable endonuclease. (281 aa)
EAS47965.1Endoribonuclease L-PSP, putative; COG0251 Putative translation initiation inhibitor, yjgF family. (127 aa)
ppnPHypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (104 aa)
EAS47903.1COG1652 Uncharacterized protein containing LysM domain. (222 aa)
EAS47902.1COG1652 Uncharacterized protein containing LysM domain. (124 aa)
EAS47749.1Hypothetical protein; COG1678 Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (192 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa)
EAS46202.1Hypothetical protein; COG0300 Short-chain dehydrogenases of various substrate specificities; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
cmkCOG0283 Cytidylate kinase. (229 aa)
EAS46885.1COG1011 Predicted hydrolase (HAD superfamily). (222 aa)
EAS46873.1MazG family protein; COG1694 Predicted pyrophosphatase. (274 aa)
EAS46811.1COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (282 aa)
EAS46796.1Hypothetical protein; COG0209 Ribonucleotide reductase, alpha subunit. (233 aa)
EAS46795.1Hypothetical protein; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (720 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (230 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (370 aa)
EAS46634.1Hypothetical protein; COG1611 Predicted Rossmann fold nucleotide-binding protein; Belongs to the LOG family. (217 aa)
EAS47509.1Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding; COG0167 Dihydroorotate dehydrogenase; Belongs to the dihydroorotate dehydrogenase family. (546 aa)
EAS47453.15'-nucleotidase. (302 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (208 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (245 aa)
rlmLHypothetical protein; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (705 aa)
EAS46140.1Oxidoreductase, short-chain dehydrogenase/reductase family protein; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (275 aa)
groSChaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (97 aa)
EAS47307.1COG0540 Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (337 aa)
Your Current Organism:
gamma proteobacterium HTCC2207
NCBI taxonomy Id: 314287
Other names: g. proteobacterium HTCC2207, marine gamma proteobacterium HTCC2207
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