STRINGSTRING
purA purA LCA_0071 LCA_0071 add add adeC1 adeC1 gmk1 gmk1 guaA guaA iunH1 iunH1 guaB guaB arcC arcC guaC guaC pgm pgm iunH2 iunH2 purE purE purK1 purK1 purB1 purB1 purC purC purS purS purQ purQ purL purL purF purF purM purM purN purN purH purH purD purD gmk2 gmk2 relA relA LCA_0774 LCA_0774 deoB deoB deoD deoD iunH3 iunH3 nrdF nrdF nrdE nrdE pyk pyk apt apt LCA_1444 LCA_1444 nrdD nrdD purB2 purB2 purK2 purK2 xpt xpt LCA_1593 LCA_1593 hpt hpt prs prs adeC2 adeC2 adk adk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purAAdenylosuccinate synthetase (IMP-aspartate ligase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (426 aa)
LCA_0071Putative carbamate kinase; Belongs to the carbamate kinase family. (311 aa)
addAdenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (339 aa)
adeC1Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (594 aa)
gmk1Guanylate kinase. (186 aa)
guaAGuanosine monophosphate synthase (Glutamine amidotransferase); Catalyzes the synthesis of GMP from XMP. (517 aa)
iunH1Inosine-uridine preferring nucleoside hydrolase. (311 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)
arcCCarbamate kinase; Belongs to the carbamate kinase family. (314 aa)
guaCGuanosine 5'-monophosphate reductase (GMP reductase); Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (325 aa)
pgmPhosphoglucomutase. (574 aa)
iunH2Inosine-uridine preferring nucleoside hydrolase. (319 aa)
purEPhospho ribosylaminoimidazole carboxylase (AIR carboxylase), catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa)
purK1Phospho ribosylaminoimidazole carboxylase (AIR carboxylase), ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (383 aa)
purB1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa)
purCPhospho ribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (241 aa)
purSPhospho ribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (86 aa)
purQPhospho ribosylformylglycinamidine synthase, glutamine amidotransferase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ a [...] (228 aa)
purLPhospho ribosylformylglycinamidine synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (741 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (477 aa)
purMPhospho ribosylformylglycinamidine cyclo-ligase. (342 aa)
purNPhospho ribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (189 aa)
purHBifunctional protein:phospho ribosylaminoimidazole carboxamide formyltransferase (AICAR transformylase)and IMP cyclohydrolase (inosinicase). (510 aa)
purDPhosphoribosylamine--glycine ligase (Phosphoribosylglycinamide synthetase); Belongs to the GARS family. (416 aa)
gmk2Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (203 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (743 aa)
LCA_0774Putative ADP-ribose pyrophosphatase, NUDIX family. (180 aa)
deoBPhosphopentomutase (Phosphodeoxyribomutase); Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (396 aa)
deoDPurine-nucleoside phosphorylase. (234 aa)
iunH3Inosine-uridine preferring nucleoside hydrolase. (324 aa)
nrdFRibonucleoside-diphosphate reductase, beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (318 aa)
nrdERibonucleoside-diphosphate reductase, alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (723 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (586 aa)
aptAdenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
LCA_14445 Proteins of unknown function that are similar to other proteins. (224 aa)
nrdDAnaerobic ribonucleoside-triphosphate reductase. (738 aa)
purB2Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (430 aa)
purK2Phospho ribosylaminoimidazole carboxylase (AIR carboxylase), ATPase subunit; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family. (370 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (195 aa)
LCA_1593Putative nucleotide diphosphate hydrolase, NUDIX family. (194 aa)
hptHypoxanthine phosphoribosyltranferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa)
prsRibose-phosphate diphosphokinase (Phosphoribosyl pyrophosphate synthetase); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa)
adeC2Adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (580 aa)
adkAdenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa)
Your Current Organism:
Lactobacillus sakei
NCBI taxonomy Id: 314315
Other names: L. sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei str. 23K, Lactobacillus sakei subsp. sakei strain 23K
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.