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prs prs fabV fabV gpmI gpmI EDQ01358.1 EDQ01358.1 FdhB FdhB EDQ01360.1 EDQ01360.1 EDQ01362.1 EDQ01362.1 FdhB-2 FdhB-2 EDQ01364.1 EDQ01364.1 pckA pckA fadB fadB pgi pgi tal tal LeuB LeuB GndA GndA AtoB AtoB MmsA MmsA folD folD fbp fbp EDQ02695.1 EDQ02695.1 gcvT gcvT gcvH gcvH gcvP gcvP Tkt Tkt pgk pgk Fda Fda rpiA rpiA ppc ppc Rpe Rpe AceE AceE Lpd Lpd AcnB AcnB EDQ00287.1 EDQ00287.1 Gap Gap fumC fumC PrkB PrkB YfcX YfcX SdaA SdaA GltA GltA SdhD SdhD sdhA sdhA sdhB sdhB SucA SucA sucC sucC sucD sucD EDP99245.1 EDP99245.1 PykA PykA zwf zwf pgl pgl edd edd Eda Eda EDP99171.1 EDP99171.1 AceA AceA glcB glcB serC serC CbbGC CbbGC Gap-2 Gap-2 Idh Idh PpsA PpsA acsA acsA CysK CysK ackA ackA Pta Pta NifP NifP NifJ NifJ YbcF YbcF eno eno glyA glyA EDQ01298.1 EDQ01298.1 CysE CysE ilvA ilvA FrdC FrdC FrdC-2 FrdC-2 FrdA FrdA FrdB FrdB AccC AccC AccB AccB metF metF Cat-2 Cat-2 mdh mdh EDQ01106.1 EDQ01106.1 maeA maeA FrmA FrmA FrmC FrmC TpiA TpiA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
fabVHypothetical protein; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (400 aa)
gpmIPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa)
EDQ01358.1Formate dehydrogenase, alpha subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (949 aa)
FdhBFormate dehydrogenase, iron-sulfur subunit; COG0437 Fe-S-cluster-containing hydrogenase components 1. (196 aa)
EDQ01360.1Formate dehydrogenase, C subunit, putative; COG2864 Cytochrome b subunit of formate dehydrogenase. (341 aa)
EDQ01362.1Formate dehydrogenase, alpha subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (951 aa)
FdhB-2Formate dehydrogenase, iron-sulfur subunit; COG0437 Fe-S-cluster-containing hydrogenase components 1. (186 aa)
EDQ01364.1Formate dehydrogenase, C subunit, putative; COG2864 Cytochrome b subunit of formate dehydrogenase. (328 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (513 aa)
fadBFatty oxidation complex, alpha subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (717 aa)
pgiCOG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family. (545 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (318 aa)
LeuBCOG0473 Isocitrate/isopropylmalate dehydrogenase. (331 aa)
GndA6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (517 aa)
AtoBCOG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
MmsACOG1012 NAD-dependent aldehyde dehydrogenases. (501 aa)
folDMethylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
fbpCOG0158 Fructose-1,6-bisphosphatase; Belongs to the FBPase class 1 family. (329 aa)
EDQ02695.1Formate dehydrogenase, alpha subunit; COG3383 Uncharacterized anaerobic dehydrogenase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1434 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (962 aa)
TktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa)
pgkCOG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (391 aa)
FdaFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
rpiARibose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (218 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (877 aa)
RpeCOG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa)
AceEPyruvate dehydrogenase complex, dehydrogenase component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (886 aa)
LpdCOG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (483 aa)
AcnBAconitate hydratase; COG1049 Aconitase B; Belongs to the aconitase/IPM isomerase family. (866 aa)
EDQ00287.1Malate oxidoreductase, putative; COG0281 Malic enzyme. (415 aa)
GapCOG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
PrkBCOG3954 Phosphoribulokinase. (295 aa)
YfcXFatty oxidation complex, alpha subunit; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (709 aa)
SdaACOG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
GltACOG0372 Citrate synthase; Belongs to the citrate synthase family. (430 aa)
SdhDCOG2142 Succinate dehydrogenase, hydrophobic anchor subunit. (54 aa)
sdhACOG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)
sdhBCOG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (235 aa)
SucACOG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (932 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
EDP99245.1Cysteine synthase/cystathionine beta-synthase family protein; COG0031 Cysteine synthase. (353 aa)
PykACOG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (490 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (232 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (608 aa)
EdaCOG0800 2-keto-3-deoxy-6-phosphogluconate aldolase. (216 aa)
EDP99171.1Fumarate hydratase, class I, anaerobic, putative; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (433 aa)
AceACOG2224 Isocitrate lyase. (527 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (722 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (352 aa)
CbbGCCOG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
Gap-2COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (478 aa)
IdhIsocitrate dehydrogenase, NADP-dependent; COG2838 Monomeric isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (741 aa)
PpsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (789 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
CysKCOG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
ackAAcetate/propionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
PtaPhosphate acetyltransferase; COG0857 BioD-like N-terminal domain of phosphotransacetylase. (616 aa)
NifPCOG1045 Serine acetyltransferase. (273 aa)
NifJCOG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. (1201 aa)
YbcFCOG0549 Carbamate kinase; Belongs to the carbamate kinase family. (321 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (430 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
EDQ01298.1COG0560 Phosphoserine phosphatase. (326 aa)
CysECOG1045 Serine acetyltransferase. (256 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (516 aa)
FrdCCOG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. (243 aa)
FrdC-2COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. (238 aa)
FrdAFumarate reductase; COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. (670 aa)
FrdBCOG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (247 aa)
AccCacetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (453 aa)
AccBacetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (161 aa)
metFCOG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (296 aa)
Cat-2COG0753 Catalase; Belongs to the catalase family. (488 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)
EDQ01106.1COG1052 Lactate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
maeAMalate oxidoreductase; COG0281 Malic enzyme. (562 aa)
FrmACOG1062 Zn-dependent alcohol dehydrogenases, class III; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (376 aa)
FrmCEsterase, putative; Serine hydrolase involved in the detoxification of formaldehyde. (285 aa)
TpiACOG0149 Triosephosphate isomerase. (35 aa)
Your Current Organism:
Shewanella benthica
NCBI taxonomy Id: 314608
Other names: S. benthica KT99, Shewanella benthica KT99, Shewanella benthica str. KT99, Shewanella benthica strain KT99
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