STRINGSTRING
ABS21822.1 ABS21822.1 ABS21888.1 ABS21888.1 racA racA ABS22186.1 ABS22186.1 ABS22223.1 ABS22223.1 ABS22664.1 ABS22664.1 ABS22681.1 ABS22681.1 xerC xerC smc smc ABS22779.1 ABS22779.1 sepF sepF ftsZ ftsZ ftsA ftsA divIB divIB murB murB murG murG murD murD tig tig minC minC ABS23386.1 ABS23386.1 ABS23314.1 ABS23314.1 xerD xerD scpA scpA scpB scpB ABS22820.1 ABS22820.1 ABS22810.1 ABS22810.1 ftsL ftsL murE murE mraY mraY spoVG spoVG murF murF ABS20839.1 ABS20839.1 ABS21080.1 ABS21080.1 ABS21124.1 ABS21124.1 ABS21170.1 ABS21170.1 gpsB gpsB ABS21605.1 ABS21605.1 noc noc murA-2 murA-2 murA murA ftsE ftsE ABS23916.1 ABS23916.1 ABS23914.1 ABS23914.1 whiA whiA murB-2 murB-2 ABS23835.1 ABS23835.1 ABS23772.1 ABS23772.1 ABS23585.1 ABS23585.1 murC murC ezrA ezrA zapA zapA engB engB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABS21822.1PFAM: transglutaminase domain protein; KEGG: bce:BC1991 putative murein endopeptidase. (386 aa)
ABS21888.1PFAM: cell divisionFtsK/SpoIIIE; KEGG: bce:BC2081 DNA segregation ATPase and related proteins (FtsK/SpoIIIE family). (1501 aa)
racAConserved hypothetical protein; Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure; Belongs to the RacA family. (158 aa)
ABS22186.1KEGG: btk:BT9727_2519 hypothetical protein. (110 aa)
ABS22223.1PFAM: Septum formation initiator; KEGG: bat:BAS2660 cell division protein DivIC. (119 aa)
ABS22664.1PFAM: Stage V sporulation protein S; KEGG: btl:BALH_3404 stage V sporulation protein S. (86 aa)
ABS22681.1PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: btl:BALH_3422 stage III sporulation protein E; Belongs to the FtsK/SpoIIIE/SftA family. (793 aa)
xerCTyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (299 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1189 aa)
ABS22779.1PFAM: DivIVA family protein; KEGG: btl:BALH_3527 cell-division initiation protein (divIVA). (168 aa)
sepFProtein of unknown function DUF552; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (156 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (384 aa)
ftsACell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (434 aa)
divIBPolypeptide-transport-associated domain protein FtsQ-type; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex; Belongs to the FtsQ/DivIB family. DivIB subfamily. (255 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (306 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (364 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (451 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (427 aa)
minCSeptum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (228 aa)
ABS23386.1TIGRFAM: septum site-determining protein MinD; PFAM: Cobyrinic acid ac-diamide synthase; KEGG: bca:BCE_4540 septum site-determining protein MinD. (265 aa)
ABS23314.1PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; KEGG: btl:BALH_3963 penicillin-binding protein. (584 aa)
xerDTyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (296 aa)
scpAChromosome segregation and condensation protein ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. (248 aa)
scpBPutative transcriptional regulator; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (190 aa)
ABS22820.1TIGRFAM: phage tail tape measure protein, TP901 family; KEGG: bat:BAS3793 prophage LambdaBa02, tape measure protein, putative. (1346 aa)
ABS22810.1PFAM: cell divisionFtsK/SpoIIIE; KEGG: bat:BAS3778 prophage LambdaBa02, FtsK/SpoIIIE family protein. (393 aa)
ftsLCell division protein FtsL; Essential cell division protein; Belongs to the FtsL family. (118 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (491 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (324 aa)
spoVGSpoVG family protein; Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation. (97 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (458 aa)
ABS20839.1PFAM: S-layer domain protein; SMART: transglutaminase domain protein; KEGG: bce:BC0991 S-layer homology domain / putative murein endopeptidase. (586 aa)
ABS21080.1KEGG: bat:BAS2049 hypothetical protein. (232 aa)
ABS21124.1TIGRFAM: LPXTG-motif cell wall anchor domain; KEGG: bce:BC3221 surface protein. (317 aa)
ABS21170.1KEGG: bca:BCE_1839 hypothetical protein. (223 aa)
gpsBDivIVA family protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. (111 aa)
ABS21605.1PFAM: phage integrase family protein; phage integrase domain protein SAM domain protein; KEGG: swo:Swol_1316 integrase/recombinase; Belongs to the 'phage' integrase family. (304 aa)
nocparB-like partition protein; Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage. Belongs to the ParB family. (290 aa)
murA-2UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (429 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (434 aa)
ftsECell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (228 aa)
ABS23916.1Protein of unknown function DUF214; Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation. Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (297 aa)
ABS23914.1KEGG: btl:BALH_4676 hypothetical protein. (394 aa)
whiAProtein of unknown function DUF199; Involved in cell division and chromosome segregation. (316 aa)
murB-2UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (304 aa)
ABS23835.1Chromosome segregation ATPase-like protein; KEGG: ehi:82.t00025 viral A-type inclusion protein repeat, putative Pfam: Nha1_C Rho_Binding ERM Prefoldin_2 WXG100 Vicilin_N TBPIP Myosin_tail_1 Filament YscO Bacillus_HBL HAP1_N EzrA DUF948 Rab5-bind Laminin_I MpPF2 MSG Spectrin LMP PROSITE: GLU_RICH LYS_RICH. (480 aa)
ABS23772.1PFAM: peptidase M23B; KEGG: btl:BALH_4505 peptidase, M23/M37 family. (328 aa)
ABS23585.1PFAM: polysaccharide biosynthesis protein; virulence factor MVIN family protein; KEGG: bat:BAS4603 polysaccharide biosynthesis family protein. (550 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (436 aa)
ezrASeptation ring formation regulator EzrA; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (569 aa)
zapAProtein of unknown function DUF710; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (94 aa)
engBSmall GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (198 aa)
Your Current Organism:
Bacillus cytotoxicus
NCBI taxonomy Id: 315749
Other names: B. cytotoxicus NVH 391-98, Bacillus cereus NVH 391-98, Bacillus cereus subsp. cytotoxicus NVH 391-98, Bacillus cereus subsp. cytotoxis NVH 391-98, Bacillus cytotoxicus NVH 391-98, Bacillus cytotoxicus str. NVH 391-98, Bacillus cytotoxicus strain NVH 391-98, Bacillus cytotoxis NVH 391-98
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