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| | ABS22846.1 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (164 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa) |
| | ABS20385.1 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: beta-lactamase; peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: bat:BAS0012 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (439 aa) |
| | ABS20389.1 | PFAM: deoxynucleoside kinase; KEGG: btl:BALH_0015 deoxynucleoside kinase. (222 aa) |
| | tmk | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (208 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (459 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | ABS20434.1 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: btl:BALH_0062 hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (262 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (276 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (622 aa) |
| | ABS20547.1 | PFAM: protein of unknown function DUF201; KEGG: bca:BCE_A0170 phosphoribosylglycinamide synthetase, ATP-grasp (A) domain protein. (411 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation. (362 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (458 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (512 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (383 aa) |
| | ABS20632.1 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: bcz:BCZK0265 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (433 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: bce:BC0326 phosphoribosylaminoimidazole-succinocarboxamide synthase. (239 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (84 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (227 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (739 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (471 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: btk:BT9727_0268 phosphoribosylaminoimidazole synthetase. (347 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (195 aa) |
| | purH | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: bat:BAS0285 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (511 aa) |
| | purD | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; ATP-grasp domain protein; KEGG: btk:BT9727_0271 phosphoribosylamine--glycine ligase; Belongs to the GARS family. (423 aa) |
| | ugtP | Monogalactosyldiacylglycerol synthase; Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta- monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D- glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-triglucosyl-DAG (3-O- (beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl-beta-(1->6)-D- glucopyranosyl)-1,2-diac [...] (388 aa) |
| | queG | Putative iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (380 aa) |
| | uppP | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (270 aa) |
| | ABS20933.1 | PFAM: GCN5-related N-acetyltransferase; KEGG: bca:BCE_0766 acetyltransferase, GNAT family. (145 aa) |
| | ABS20980.1 | PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: btk:BT9727_0664 conserved hypothetical protein, ErfK/YbiS/YcfS/YnhG family protein. (253 aa) |
| | ABS21062.1 | PFAM: membrane bound O-acyl transferase MBOAT family protein; KEGG: btl:BALH_0803 alginate O-acetyltransferase; Belongs to the membrane-bound acyltransferase family. (470 aa) |
| | ABS21063.1 | PFAM: membrane bound O-acyl transferase MBOAT family protein; KEGG: bca:BCE_0976 alginate O-acetyltransferase, putative; Belongs to the membrane-bound acyltransferase family. (485 aa) |
| | ABS21072.1 | PFAM: cell cycle protein; KEGG: bce:BC3948 cell division protein ftsW; Belongs to the SEDS family. (381 aa) |
| | ABS21248.1 | PFAM: RelA/SpoT domain protein; KEGG: btl:BALH_1060 GTP pyrophosphokinase. (212 aa) |
| | ABS21253.1 | PFAM: cell cycle protein; KEGG: bce:BC1203 cell division protein FtsW; Belongs to the SEDS family. (386 aa) |
| | ABS21270.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa) |
| | ABS21272.1 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (283 aa) |
| | ABS21276.1 | PFAM: GCN5-related N-acetyltransferase; KEGG: bca:BCE_1347 acetyltransferase, GNAT family. (123 aa) |
| | ABS21299.1 | TIGRFAM: cytidyltransferase-related domain; PFAM: Riboflavin kinase / FAD synthetase; cytidylyltransferase; KEGG: bce:BC3807 riboflavin kinase; Belongs to the ribF family. (288 aa) |
| | ABS21324.1 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: bcz:BCZK1171 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (423 aa) |
| | ABS21357.1 | PFAM: beta-lactamase; KEGG: bld:BLi01294 PbpE; Belongs to the class-A beta-lactamase family. (358 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (220 aa) |
| | ABS21391.1 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: bat:BAS1258 6-pyruvoyl tetrahydrobiopterin synthase, putative. (164 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (238 aa) |
| | queF | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (165 aa) |
| | ABS21402.1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (322 aa) |
| | ABS21415.1 | PFAM: DltD domain protein; DltD central domain protein; KEGG: bce:BC1369 protein dltD precursor. (391 aa) |
| | dltC | D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (79 aa) |
| | ABS21417.1 | Membrane bound O-acyl transferase MBOAT family protein; Could be involved in the transport of activated D-alanine through the membrane. (388 aa) |
| | dltA | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] (504 aa) |
| | ABS21426.1 | PFAM: sulfatase; KEGG: lin:lin0647 hypothetical protein; Belongs to the LTA synthase family. (609 aa) |
| | uppP-2 | Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (263 aa) |
| | ABS21464.1 | PFAM: sulfatase; KEGG: bca:BCE_1538 sulfatase; Belongs to the LTA synthase family. (628 aa) |
| | ABS21515.1 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: bca:BCE_1594 D-alanyl-D-alanine carboxypeptidase family protein; Belongs to the peptidase S11 family. (373 aa) |
| | ABS21533.1 | PFAM: metallophosphoesterase; KEGG: btl:BALH_1344 phosphoesterase. (238 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase (NAD(P)(+)); PFAM: NADP oxidoreductase coenzyme F420-dependent; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; 6-phosphogluconate dehydrogenase NAD-binding; KEGG: bce:BC1505 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (341 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (148 aa) |
| | ABS21580.1 | PFAM: LmbE family protein; KEGG: bat:BAS1444 hypothetical protein. (234 aa) |
| | ABS21581.1 | PFAM: glycosyl transferase group 1; KEGG: bce:BC1535 glycosyltransferase. (381 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (197 aa) |
| | ABS21660.1 | PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: bca:BCE_1745 hypothetical protein. (200 aa) |
| | ABS21683.1 | TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase; KEGG: bcz:BCZK1526 flagellum-specific ATP synthase. (434 aa) |
| | ABS21693.1 | PFAM: glycosyl transferase family 2; TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: lwe:lwe0657 glycosyl transferase, group 2 family protein. (633 aa) |
| | ABS21806.1 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: btl:BALH_1727 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (339 aa) |
| | amj | Conserved hypothetical protein; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (265 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (318 aa) |
| | ABS21950.1 | Peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; NTF2 domain protein transpeptidase; KEGG: bat:BAS2084 penicillin-binding protein 3. (661 aa) |
| | ABS21974.1 | PFAM: glycosyl transferase family 2; KEGG: btl:BALH_2035 glycosyltransferase. (404 aa) |
| | ABS22005.1 | PFAM: phosphoesterase PA-phosphatase related; KEGG: btk:BT9727_2092 phosphatidylglycerophosphatase B. (211 aa) |
| | ABS22013.1 | PFAM: metallophosphoesterase; KEGG: bcz:pE33L466_0391 possible DNA repair exonuclease. (282 aa) |
| | ABS22014.1 | PFAM: Monogalactosyldiacylglycerol synthase; KEGG: bcz:pE33L466_0393 possible UDP-glucuronosyltransferase. (382 aa) |
| | ABS22016.1 | PFAM: phosphoesterase PA-phosphatase related; KEGG: bcz:pE33L466_0399 phosphatase. (176 aa) |
| | ABS22082.1 | PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: bcz:BCZK2203 GTP pyrophosphokinase. (177 aa) |
| | ABS22102.1 | Carbamoyl-phosphate synthase L chain ATP-binding; PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: bcz:BCZK2286 acetyl-CoA carboxylase. (445 aa) |
| | ABS22109.1 | PFAM: glycosyl transferase family 2; KEGG: bcz:pE33L466_0435 glycosyltransferase. (513 aa) |
| | ABS22111.1 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: bar:GBAA2559 D-alanyl-D-alanine carboxypeptidase family protein; Belongs to the peptidase S11 family. (337 aa) |
| | ABS22155.1 | PFAM: glycosyl transferase family 2; KEGG: bce:BC3001 glycosyltransferase involved in cell wall biogenesis. (507 aa) |
| | ABS22156.1 | PFAM: glycosyl transferase family 2; KEGG: bcz:BCZK2744 glycosyl transferase, group 2 family protein. (503 aa) |
| | ABS22200.1 | PFAM: GCN5-related N-acetyltransferase; KEGG: bcz:BCZK2522 acetyltransferase, GNAT family. (145 aa) |
| | ABS22218.1 | PFAM: phosphoribulokinase/uridine kinase; KEGG: btl:BALH_2853 possible uridine kinase. (215 aa) |
| | ABS22263.1 | TIGRFAM: pantothenate kinase; PFAM: Fumble domain protein; KEGG: btl:BALH_2604 possible pantothenate kinase. (276 aa) |
| | ABS22275.1 | PFAM: DNA/pantothenate metabolism flavoprotein domain protein; KEGG: bat:BAS2721 hypothetical protein. (232 aa) |
| | ABS22285.1 | PFAM: sulfatase; KEGG: bca:BCE_2987 sulfatase; Belongs to the LTA synthase family. (657 aa) |
| | ABS22303.1 | Uridine kinase; KEGG: btk:BT9727_2748 uridine kinase. (71 aa) |
| | ABS22318.1 | KEGG: btl:BALH_2743 hypothetical protein. (267 aa) |
| | ABS22322.1 | PFAM: phosphoesterase PA-phosphatase related; KEGG: btk:BT9727_2497 bacitracin transport permease. (199 aa) |
| | ABS22340.1 | PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; KEGG: gka:GK0840 NDP-sugar dehydrogenase. (428 aa) |
| | ABS22412.1 | PFAM: UDP-glucose/GDP-mannose dehydrogenase; KEGG: cpe:CPE0494 UDPglucose 6-dehydrogenase. (300 aa) |
| | ABS22444.1 | PFAM: LmbE family protein; KEGG: btl:BALH_3121 hypothetical protein. (220 aa) |
| | ABS22445.1 | PFAM: Protein of unknown function DUF1806; KEGG: bcz:BCZK3184 hypothetical protein. (116 aa) |
| | ABS22500.1 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (150 aa) |
| | ABS22535.1 | PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; NmrA family protein; KEGG: oih:OB3381 hypothetical protein. (321 aa) |
| | ABS22602.1 | PFAM: beta-lactamase; KEGG: bsu:BG10390 penicillin-binding protein 4*. (381 aa) |
| | ABS22697.1 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase; cytidylyltransferase; KEGG: bce:BC3807 riboflavin kinase; Belongs to the ribF family. (323 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | ABS22731.1 | KEGG: btl:BALH_3474 KH domain family; Belongs to the UPF0109 family. (75 aa) |
| | ABS22757.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (401 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (238 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (309 aa) |
| | pyrK | Oxidoreductase FAD/NAD(P)-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (259 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; RimK domain protein ATP-grasp; KEGG: btk:BT9727_3628 carbamoyl-phosphate synthase. (1072 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: bce:BC3887 carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (373 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: btk:BT9727_3631 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (304 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (306 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (364 aa) |
| | ABS22795.1 | TIGRFAM: cell division protein FtsW; stage V sporulation protein E; PFAM: cell cycle protein; KEGG: bat:BAS3762 stage V sporulation protein E; Belongs to the SEDS family. (363 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (451 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (324 aa) |
| | murE | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (491 aa) |
| | ABS22799.1 | TIGRFAM: stage V sporulation protein D; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; PASTA domain containing protein; KEGG: bce:BC3915 stage V sporulation protein D / sporulation specific D,D-transpeptidase. (638 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (163 aa) |
| | ABS22884.1 | PFAM: cell cycle protein; KEGG: bce:BC3948 cell division protein ftsW; Belongs to the SEDS family. (391 aa) |
| | ABS22927.1 | PFAM: metallophosphoesterase; KEGG: bca:BCE_4041 Ser/Thr protein phosphatase family protein. (287 aa) |
| | ABS23007.1 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: btl:BALH_3693 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (392 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (395 aa) |
| | ABS23030.1 | PFAM: protein of unknown function UPF0157; KEGG: bca:BCE_4167 hypothetical protein. (174 aa) |
| | ABS23078.1 | PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: btk:BT9727_3894 conserved hypothetical protein, possible ErfK/SrfK protein. (169 aa) |
| | ABS23086.1 | PFAM: cell cycle protein; KEGG: bcz:BCZK3911 cell division protein, FtsW/RodA/SpoVE family; Belongs to the SEDS family. (392 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (630 aa) |
| | ABS23110.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa) |
| | ABS23228.1 | PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; KEGG: bce:BC4270 penicillin-binding protein. (705 aa) |
| | ABS23294.1 | PFAM: RelA/SpoT domain protein; KEGG: btl:BALH_3933 GTP diphosphokinase. (216 aa) |
| | ABS23314.1 | PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; KEGG: btl:BALH_3963 penicillin-binding protein. (584 aa) |
| | udk | TIGRFAM: uridine kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: btl:BALH_3965 uridine kinase. (212 aa) |
| | mltG | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (355 aa) |
| | ABS23347.1 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (727 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (379 aa) |
| | queA | S-adenosylmethionine--tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (350 aa) |
| | ABS23418.1 | TIGRFAM: amino acid adenylation domain; PFAM: AMP-dependent synthetase and ligase; condensation domain protein; short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: ava:Ava_3984 amino acid adenylation; Belongs to the ATP-dependent AMP-binding enzyme family. (2031 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (267 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (324 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa) |
| | ABS23551.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: bce:BC4659 acetyl-coenzyme A synthetase. (572 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (436 aa) |
| | ABS23585.1 | PFAM: polysaccharide biosynthesis protein; virulence factor MVIN family protein; KEGG: bat:BAS4603 polysaccharide biosynthesis family protein. (550 aa) |
| | ABS23592.1 | Hypothetical protein; KEGG: bsu:BG13586 similar to glycosyltransferase. (327 aa) |
| | ABS23662.1 | KEGG: bca:BCE_4932 hypothetical protein. (417 aa) |
| | ABS23688.1 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: bce:BC4815 hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | dacB | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (201 aa) |
| | ABS23799.1 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: penicillin-binding protein transpeptidase; peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: bca:BCE_5147 D-alanyl-D-alanine carboxypeptidase family protein; Belongs to the peptidase S11 family. (279 aa) |
| | murB-2 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (304 aa) |
| | ABS23897.1 | PFAM: protein of unknown function DUF368; KEGG: btl:BALH_4649 hypothetical protein. (268 aa) |
| | ABS23937.1 | PFAM: UDP-N-acetylglucosamine 2-epimerase; KEGG: btl:BALH_4693 UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (371 aa) |
| | ABS23938.1 | PFAM: glycosyl transferase family 4; KEGG: bce:BC5203 undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase. (357 aa) |
| | ABS23957.1 | PFAM: sulfatase; KEGG: bca:BCE_5348 sulfatase; Belongs to the LTA synthase family. (642 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (144 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (434 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (133 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (464 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (286 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (502 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (180 aa) |
| | atpF | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (168 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (72 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (239 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | murA-2 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (429 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (535 aa) |
| | ABS24092.1 | TIGRFAM: phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; KEGG: btl:BALH_4886 phosphate acetyltransferase. (323 aa) |
| | ABS24094.1 | Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: bca:BCE_5518 D-alanyl-D-alanine carboxypeptidase, putative; Belongs to the peptidase S11 family. (425 aa) |
| | ABS24118.1 | Glycosyl transferase, WecB/TagA/CpsF family; Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. (246 aa) |
| | ABS24126.1 | KEGG: btk:BT9727_5104 conserved hypothetical protein, possible permease. (437 aa) |
| | ABS24130.1 | KEGG: bce:BC5428 hypothetical protein. (430 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
