STRINGSTRING
BPUM_2393 BPUM_2393 BPUM_2395 BPUM_2395 thiC thiC thiI thiI thiM thiM BPUM_2639 BPUM_2639 BPUM_3116 BPUM_3116 thiE thiE BPUM_3132 BPUM_3132 adk adk thiL thiL BPUM_0641 BPUM_0641 BPUM_0663 BPUM_0663 BPUM_0893 BPUM_0893 BPUM_0896 BPUM_0896 BPUM_1094 BPUM_1094 BPUM_3574 BPUM_3574 BPUM_1095 BPUM_1095 BPUM_1096 BPUM_1096 thiG thiG BPUM_1100 BPUM_1100 BPUM_1235 BPUM_1235 rsgA rsgA BPUM_1479 BPUM_1479 BPUM_1670 BPUM_1670 BPUM_1800 BPUM_1800 dxs dxs BPUM_2392 BPUM_2392
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BPUM_2393Rrf2 family transcriptional regulator. (139 aa)
BPUM_2395Hypothetical protein. (254 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (585 aa)
thiIThiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (401 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (271 aa)
BPUM_2639Phosphotransferase. (270 aa)
BPUM_3116NUDIX hydrolase. (154 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (222 aa)
BPUM_3132Rrf2 family transcriptional regulator. (142 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
thiLThiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa)
BPUM_0641Alkaline phosphatase; Belongs to the alkaline phosphatase family. (468 aa)
BPUM_0663Rrf2 family transcriptional regulator. (145 aa)
BPUM_0893Rrf2 family transcriptional regulator. (143 aa)
BPUM_0896Alkaline phosphatase; Belongs to the alkaline phosphatase family. (454 aa)
BPUM_1094Thiaminase II; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (236 aa)
BPUM_3574Thiaminase II; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (228 aa)
BPUM_1095Transcriptional regulator. (205 aa)
BPUM_1096Glycine oxidase. (370 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (255 aa)
BPUM_1100Phosphomethylpyrimidine kinase. (268 aa)
BPUM_1235Hypothetical protein. (204 aa)
rsgAGTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (298 aa)
BPUM_1479Thiamine pyrophosphokinase. (214 aa)
BPUM_1670Rrf2 family transcriptional regulator. (137 aa)
BPUM_1800Hypothetical protein. (200 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa)
BPUM_2392Cysteine desulfurase. (380 aa)
Your Current Organism:
Bacillus pumilus
NCBI taxonomy Id: 315750
Other names: B. pumilus SAFR-032, Bacillus pumilus SAFR-032, Bacillus pumilus str. SAFR-032, Bacillus pumilus strain SAFR-032
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.