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purH purH RPC_0056 RPC_0056 cysD cysD RPC_0064 RPC_0064 RPC_0143 RPC_0143 RPC_0324 RPC_0324 purC purC RPC_1131 RPC_1131 RPC_1132 RPC_1132 RPC_1133 RPC_1133 RPC_1152 RPC_1152 RPC_1233 RPC_1233 cpdA cpdA prs prs purC-2 purC-2 purS purS purQ purQ purL purL RPC_1610 RPC_1610 purF purF gmk gmk ndk ndk purN purN purM purM RPC_2330 RPC_2330 RPC_2380 RPC_2380 RPC_2507 RPC_2507 surE surE RPC_2635 RPC_2635 RPC_2752 RPC_2752 RPC_2956 RPC_2956 guaA guaA guaB guaB RPC_3082 RPC_3082 gpt gpt adk adk RPC_3517 RPC_3517 RPC_3518 RPC_3518 RPC_3519 RPC_3519 ureC ureC ureB ureB ureA ureA RPC_3722 RPC_3722 RPC_3876 RPC_3876 purE purE purK purK RPC_3982 RPC_3982 RPC_4016 RPC_4016 cysC cysC purA purA RPC_4230 RPC_4230 RPC_4239 RPC_4239 apt apt purD purD RPC_4638 RPC_4638 RPC_4639 RPC_4639 RPC_4640 RPC_4640 RPC_4694 RPC_4694
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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purHPhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (530 aa)
RPC_0056Glutamine amidotransferase class-I. (260 aa)
cysDSulfate adenylyltransferase subunit 2. (328 aa)
RPC_0064Adenylylsulfate kinase / sulfate adenylyltransferase subunit 1. (617 aa)
RPC_0143Ham1-like protein. (215 aa)
RPC_0324Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (211 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (305 aa)
RPC_1131Xanthine dehydrogenase, molybdenum binding subunit apoprotein. (750 aa)
RPC_1132Molybdopterin dehydrogenase, FAD-binding. (316 aa)
RPC_1133Twin-arginine translocation pathway signal. (218 aa)
RPC_11525'-Nucleotidase-like; Belongs to the 5'-nucleotidase family. (558 aa)
RPC_1233Phosphoglucomutase, alpha-D-glucose phosphate-specific. (550 aa)
cpdAMetallophosphoesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (275 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa)
purC-2Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (265 aa)
purSPhosphoribosylformylglycinamidine synthetase PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...] (82 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (233 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (736 aa)
RPC_1610Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (503 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (219 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (218 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (357 aa)
RPC_2330Ppx/GppA phosphatase. (501 aa)
RPC_2380Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1262 aa)
RPC_2507Deoxyguanosinetriphosphate triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily. (404 aa)
surE3'-nucleotidase / 5'-nucleotidase / exopolyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (255 aa)
RPC_2635(p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (761 aa)
RPC_2752MazG family protein. (274 aa)
RPC_2956Pyruvate kinase; Belongs to the pyruvate kinase family. (502 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (535 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (497 aa)
RPC_3082Ppx/GppA phosphatase. (366 aa)
gptXanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (174 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (335 aa)
RPC_3517Ribonucleoside-triphosphate reductase, anaerobic. (673 aa)
RPC_3518Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (386 aa)
RPC_3519Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (960 aa)
ureCUrease. Metallo peptidase. MEROPS family M38; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (570 aa)
ureBUrease, beta subunit; Belongs to the urease beta subunit family. (104 aa)
ureAUrease, gamma subunit; Belongs to the urease gamma subunit family. (100 aa)
RPC_3722Nucleoside diphosphate pyrophosphatase. (214 aa)
RPC_3876Metallophosphoesterase. (252 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (366 aa)
RPC_3982Pyruvate kinase; Belongs to the pyruvate kinase family. (475 aa)
RPC_4016Sulfate adenylyltransferase subunit 2. (268 aa)
cysCSulfate adenylyltransferase subunit 1 / adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (639 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
RPC_4230Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (343 aa)
RPC_4239Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II. (499 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (199 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (427 aa)
RPC_4638(2Fe-2S)-binding. (179 aa)
RPC_4639Molybdopterin dehydrogenase, FAD-binding. (331 aa)
RPC_4640Xanthine dehydrogenase, molybdenum binding subunit apoprotein. (756 aa)
RPC_4694Putative adenylate/guanylate cyclase. (340 aa)
Your Current Organism:
Rhodopseudomonas palustris BisB18
NCBI taxonomy Id: 316056
Other names: R. palustris BisB18, Rhodopseudomonas palustris str. BisB18, Rhodopseudomonas palustris strain BisB18
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