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rplD rplD rplC rplC rpsJ rpsJ rpsG rpsG rpsL rpsL rplL rplL rplJ rplJ rplA rplA rplK rplK RPB_2259 RPB_2259 RPB_2237 RPB_2237 RPB_2116 RPB_2116 RPB_2007 RPB_2007 RPB_1979 RPB_1979 RPB_1826 RPB_1826 RPB_1805 RPB_1805 RPB_1726 RPB_1726 RPB_1719 RPB_1719 RPB_1717 RPB_1717 RPB_1683 RPB_1683 RPB_1652 RPB_1652 rpsU rpsU rpmJ rpmJ clpS clpS queE queE RPB_1130 RPB_1130 smc smc RPB_0818 RPB_0818 rpmH rpmH RPB_0667 RPB_0667 recR recR hpf hpf RPB_0640 RPB_0640 ihfB ihfB rpsO rpsO rpmB rpmB rpmF rpmF RPB_0388 RPB_0388 rpsP rpsP rimM rimM rplS rplS RPB_0303 RPB_0303 priA priA rpmA rpmA rplU rplU RPB_0125 RPB_0125 RPB_0097 RPB_0097 rplT rplT rpmI rpmI gyrB gyrB RPB_4514 RPB_4514 RPB_4701 RPB_4701 rpsT rpsT clpS-2 clpS-2 rpmG rpmG topA topA RPB_2431 RPB_2431 RPB_2458 RPB_2458 rplI rplI rpsR rpsR rpsF rpsF RPB_2482 RPB_2482 RPB_2523 RPB_2523 RPB_2529 RPB_2529 RPB_2557 RPB_2557 recO recO parC parC rplM rplM rpsI rpsI RPB_2324 RPB_2324 rpsB rpsB gyrA gyrA parE parE RPB_3043 RPB_3043 RPB_3101 RPB_3101 RPB_3117 RPB_3117 RPB_3273 RPB_3273 RPB_3305 RPB_3305 RPB_3412 RPB_3412 RPB_3521 RPB_3521 RPB_3531 RPB_3531 RPB_3537 RPB_3537 RPB_3642 RPB_3642 RPB_3651 RPB_3651 RPB_3669 RPB_3669 rpsD rpsD RPB_3889 RPB_3889 RPB_3963 RPB_3963 RPB_4079 RPB_4079 dnaG dnaG rplY rplY RPB_4220 RPB_4220 RPB_4262 RPB_4262 RPB_4264 RPB_4264 rpmE rpmE rplQ rplQ rpsK rpsK rpsM rpsM rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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rplDLSU ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (206 aa)
rplCLSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (241 aa)
rpsJSSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpsGSSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsLSSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. (123 aa)
rplLLSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (123 aa)
rplJLSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (172 aa)
rplALSU ribosomal protein L1P; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
rplKLSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (142 aa)
RPB_2259Transcriptional regulator, TetR family. (221 aa)
RPB_2237Transcriptional regulator, TetR family. (228 aa)
RPB_2116Transcriptional regulator, TetR family. (218 aa)
RPB_2007DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (561 aa)
RPB_1979Transcriptional regulator, TetR family. (216 aa)
RPB_1826Transcriptional regulator, TetR family. (250 aa)
RPB_1805Transcriptional regulator, TetR family. (235 aa)
RPB_1726Squalene cyclase. (654 aa)
RPB_1719Ethanolamine ammonia-lyase light chain; Belongs to the EutC family. (259 aa)
RPB_1717Ethanolamine ammonia-lyase heavy chain. (460 aa)
RPB_1683Transcriptional regulator, TetR family. (227 aa)
RPB_1652Class II aldolase/adducin-like. (257 aa)
rpsUSSU ribosomal protein S21P; Belongs to the bacterial ribosomal protein bS21 family. (101 aa)
rpmJLSU ribosomal protein L36P; Belongs to the bacterial ribosomal protein bL36 family. (41 aa)
clpSATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (101 aa)
queERadical SAM; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (210 aa)
RPB_1130Protein of unknown function DUF159; Belongs to the SOS response-associated peptidase family. (259 aa)
smcCondensin subunit Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1154 aa)
RPB_0818ATP:cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
rpmHLSU ribosomal protein L34P; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
RPB_0667Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (106 aa)
recRDNA replication and repair protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa)
hpfSSU ribosomal protein S30P / sigma 54 modulation protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (202 aa)
RPB_0640SSU ribosomal protein S1P; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. (565 aa)
ihfBIntegration host factor, beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (101 aa)
rpsOSSU ribosomal protein S15P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
rpmBLSU ribosomal protein L28P; Belongs to the bacterial ribosomal protein bL28 family. (101 aa)
rpmFLSU ribosomal protein L32P; Belongs to the bacterial ribosomal protein bL32 family. (60 aa)
RPB_0388Chromosome segregation DNA-binding protein; Belongs to the ParB family. (296 aa)
rpsPSSU ribosomal protein S16P; Belongs to the bacterial ribosomal protein bS16 family. (110 aa)
rimM16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (182 aa)
rplSLSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (131 aa)
RPB_0303Transcriptional regulator, TetR family. (200 aa)
priAReplication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (735 aa)
rpmALSU ribosomal protein L27P; Belongs to the bacterial ribosomal protein bL27 family. (89 aa)
rplULSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (128 aa)
RPB_0125Transcriptional regulator, TetR family. (238 aa)
RPB_0097Transcriptional regulator, TetR family. (207 aa)
rplTLSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa)
rpmILSU ribosomal protein L35P; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (813 aa)
RPB_4514Transcriptional regulator, TetR family. (202 aa)
RPB_4701ATP-dependent DNA helicase RecQ. (618 aa)
rpsTSSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. (88 aa)
clpS-2ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (132 aa)
rpmGLSU ribosomal protein L33P; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (911 aa)
RPB_2431Transcriptional regulator, TetR family. (214 aa)
RPB_2458Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (498 aa)
rplILSU ribosomal protein L9P; Binds to the 23S rRNA. (196 aa)
rpsRSSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (79 aa)
rpsFSSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. (159 aa)
RPB_2482DNA polymerase III, chi subunit. (150 aa)
RPB_2523Hypothetical protein. (572 aa)
RPB_2529Hypothetical protein. (403 aa)
RPB_2557Transcriptional regulator, TetR family. (250 aa)
recODNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination. (249 aa)
parCDNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (753 aa)
rplMLSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (154 aa)
rpsISSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (158 aa)
RPB_2324Recombination protein MgsA. (444 aa)
rpsBSSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (331 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (925 aa)
parEDNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (684 aa)
RPB_3043ADP-ribosyl-(dinitrogen reductase) hydrolase. (298 aa)
RPB_3101Transcriptional regulator, TetR family. (230 aa)
RPB_3117Transcriptional regulator, TetR family. (248 aa)
RPB_3273Transcriptional regulator, TetR family. (210 aa)
RPB_3305Transcriptional regulator, TetR family. (195 aa)
RPB_3412Transcriptional regulator, TetR family. (206 aa)
RPB_3521Class II aldolase/adducin-like. (259 aa)
RPB_3531Conserved hypothetical protein. (135 aa)
RPB_3537Glutathione-dependent formaldehyde-activating, GFA. (154 aa)
RPB_3642Transcriptional regulator, TetR family. (227 aa)
RPB_3651Transcriptional regulator, TetR family. (233 aa)
RPB_3669Transcriptional regulator, TetR family. (243 aa)
rpsDSSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (205 aa)
RPB_3889Class II aldolase/adducin-like. (250 aa)
RPB_3963Ribulose 1,5-bisphosphate carboxylase small subunit. (140 aa)
RPB_4079Transcriptional regulator, TetR family. (244 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (683 aa)
rplYLSU ribosomal protein L25P; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (240 aa)
RPB_4220Transcriptional regulator, TetR family. (204 aa)
RPB_4262Transcriptional regulator, TetR family. (226 aa)
RPB_4264Transcriptional regulator, TetR family. (181 aa)
rpmELSU ribosomal protein L31P; Binds the 23S rRNA; Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily. (75 aa)
rplQLSU ribosomal protein L17P. (138 aa)
rpsKSSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rpsMSSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (122 aa)
rplOLSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (161 aa)
rpmDLSU ribosomal protein L30P. (64 aa)
rpsESSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (191 aa)
rplRLSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (120 aa)
rplFLSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rpsHSSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsNSSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (101 aa)
rplELSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (185 aa)
rplXLSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (104 aa)
rplNLSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQSSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (82 aa)
rpmCLSU ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (69 aa)
rplPLSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (137 aa)
rpsCSSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (232 aa)
rplVLSU ribosomal protein L22P; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (128 aa)
rpsSSSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa)
rplBLSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (278 aa)
rplWLSU ribosomal protein L23P; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (99 aa)
Your Current Organism:
Rhodopseudomonas palustris HaA2
NCBI taxonomy Id: 316058
Other names: R. palustris HaA2, Rhodopseudomonas palustris str. HaA2, Rhodopseudomonas palustris strain HaA2
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