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| | argJ | Glutamate N-acetyltransferase / N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa) |
| | RPB_0077 | Aspartate kinase; Belongs to the aspartokinase family. (417 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (462 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (376 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (430 aa) |
| | RPB_0291 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (920 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (370 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (293 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (245 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (107 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (271 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (504 aa) |
| | RPB_0444 | 6-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (312 aa) |
| | RPB_0477 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (332 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (205 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (382 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (404 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (218 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (445 aa) |
| | dapE | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (389 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (310 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (298 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (407 aa) |
| | RPB_0784 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (328 aa) |
| | argH | Argininosuccinate lyase. (465 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa) |
| | RPB_0842 | Arginase; Belongs to the arginase family. (328 aa) |
| | RPB_0850 | Glutamate synthase (NADPH) small chain; Sulfide dehydrogenase (flavoprotein) subunit SudA / sulfide dehydrogenase (flavoprotein) subunit SudB. (942 aa) |
| | hisE-2 | phosphoribosyl-ATP pyrophosphatase. (133 aa) |
| | RPB_0949 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (671 aa) |
| | RPB_0950 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (361 aa) |
| | RPB_0998 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. (559 aa) |
| | RPB_0999 | Aminotransferase, class IV. (290 aa) |
| | metAS | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (333 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | RPB_1297 | Aminotransferase. (400 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa) |
| | RPB_1314 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (390 aa) |
| | RPB_1315 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa) |
| | thrB | Homoserine kinase; Belongs to the pseudomonas-type ThrB family. (326 aa) |
| | RPB_1405 | L-glutamine synthetase. (367 aa) |
| | RPB_1423 | Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa) |
| | RPB_1541 | Asparagine synthase, glutamine-hydrolyzing. (631 aa) |
| | RPB_1548 | Asparagine synthase, glutamine-hydrolyzing. (647 aa) |
| | RPB_1584 | Methionine synthase, vitamin-B12 independent. (372 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (398 aa) |
| | RPB_1623 | L-threonine ammonia-lyase. (328 aa) |
| | RPB_1642 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (347 aa) |
| | RPB_1703 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. (558 aa) |
| | RPB_1764 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1304 aa) |
| | RPB_1767 | Prephenate dehydratase. (284 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric) / ATP phosphoribosyltransferase regulatory subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (325 aa) |
| | RPB_1846 | ATP phosphoribosyltransferase regulatory subunit. (385 aa) |
| | tal | Transaldolase / glucose-6-phosphate isomerase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the GPI family. (950 aa) |
| | RPB_2064 | Asparagine synthase, glutamine-hydrolyzing. (582 aa) |
| | RPB_2078 | Diaminopimelate decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (428 aa) |
| | RPB_2095 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (602 aa) |
| | RPB_2135 | Serine O-acetyltransferase. (302 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (148 aa) |
| | RPB_2269 | L-glutamine synthetase. (476 aa) |
| | RPB_2353 | Dihydrodipicolinate synthetase; Belongs to the DapA family. (317 aa) |
| | RPB_2506 | Acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (426 aa) |
| | RPB_2558 | L-glutamine synthetase. (469 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (265 aa) |
| | RPB_2813 | Citrate synthase; Belongs to the citrate synthase family. (434 aa) |
| | RPB_2907 | Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (346 aa) |
| | RPB_2913 | Cystathionine beta-lyase. (398 aa) |
| | RPB_2966 | Homoserine dehydrogenase. (440 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (331 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa) |
| | RPB_3087 | Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (405 aa) |
| | RPB_3134 | Acetolactate synthase I. (527 aa) |
| | RPB_3135 | Acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (432 aa) |
| | RPB_3169 | Pyruvate kinase; Belongs to the pyruvate kinase family. (492 aa) |
| | RPB_3210 | Methionine synthase (B12-independent). (340 aa) |
| | RPB_3247 | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (569 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (524 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | RPB_3344 | Acetolactate synthase, small subunit. (180 aa) |
| | RPB_3345 | Acetolactate synthase, large subunit. (592 aa) |
| | RPB_3347 | Phosphoserine phosphatase. (297 aa) |
| | RPB_3371 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (532 aa) |
| | RPB_3383 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (462 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (232 aa) |
| | RPB_3689 | Ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (232 aa) |
| | RPB_3700 | Aromatic amino acid beta-eliminating lyase/threonine aldolase. (355 aa) |
| | trpB-2 | Tryptophan synthase, beta chain-like; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa) |
| | RPB_3732 | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (408 aa) |
| | RPB_3736 | GCN5-related N-acetyltransferase. (252 aa) |
| | RPB_3802 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (600 aa) |
| | RPB_3930 | Acetolactate synthase large subunit. (514 aa) |
| | RPB_3958 | Dihydrodipicolinate synthetase; Belongs to the DapA family. (291 aa) |
| | ilvD | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (619 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (281 aa) |
| | RPB_4175 | Branched chain amino acid aminotransferase. (371 aa) |
| | RPB_4226 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (331 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (400 aa) |
| | hisC | Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa) |
| | RPB_4255 | Prephenate dehydrogenase. (313 aa) |
| | RPB_4318 | Anthranilate synthase, component II / anthranilate synthase, component I. (720 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (447 aa) |
| | RPB_4420 | L-threonine synthase. (420 aa) |
| | RPB_4433 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (353 aa) |
| | RPB_4466 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (662 aa) |
| | RPB_4467 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (398 aa) |
| | RPB_4471 | Fructose-bisphosphate aldolase. (346 aa) |
| | dapA-2 | Dihydrodipicolinate synthetase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | RPB_4530 | Glutamate synthase (NADH) small subunit. (484 aa) |
| | RPB_4531 | Glutamate synthase (NADH) large subunit. (1579 aa) |
| | RPB_4578 | L-threonine synthase. (472 aa) |
