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| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | dnaA | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (467 aa) |
| | recF | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (362 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (813 aa) |
| | Tcr_0013 | PFAM: phosphoribulokinase/uridine kinase; KEGG: pma:Pro0861 phosphoribulokinase. (313 aa) |
| | tsaC | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. (186 aa) |
| | Tcr_0032 | ATP-binding cassette (ABC) superfamily transporter, ATPase component; PFAM: ABC transporter related; SMART: ATPase; KEGG: btk:BT9727_2665 alkanesulfonates transport ATP-binding protein. (265 aa) |
| | Tcr_0033 | ATP-binding cassette (ABC) superfamily transporter, solute-binding component; TIGRFAM: Twin-arginine translocation pathway signal; KEGG: ppu:PP3636 sulfonate ABC transporter, periplasmic sulfonate-binding protein, putative. (417 aa) |
| | Tcr_0034 | ATP-binding cassette (ABC) superfamily transporter, permease component; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: pae:PA2327 putative nitrate transport system permease protein. (276 aa) |
| | Tcr_0035 | Transcriptional regulator, NifA subfamily, Fis family; PFAM: sigma-54 factor, interaction region helix-turn-helix, Fis-type GAF; SMART: ATPase; KEGG: dvu:DVUA0143 Nif-specific regulatory protein. (564 aa) |
| | thrB | Homoserine kinase; KEGG: neu:NE1471 putative homoserine kinase protein; TIGRFAM: homoserine kinase; PFAM: aminoglycoside phosphotransferase; Belongs to the pseudomonas-type ThrB family. (326 aa) |
| | Tcr_0070 | long-chain-fatty-acid-CoA ligase of the AMP binding family; PFAM: AMP-dependent synthetase and ligase phospholipid/glycerol acyltransferase; KEGG: bja:bll2324 long-chain-fatty-acid--[acyl-carrier-protein] ligase / acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase. (717 aa) |
| | Tcr_0076 | PFAM: ATPase associated with various cellular activities, AAA_3; KEGG: ilo:IL0995 MoxR-like ATPase. (323 aa) |
| | Tcr_0095 | PFAM: ATPase associated with various cellular activities, AAA_3 ATPase associated with various cellular activities, AAA_5; SMART: ATPase; KEGG: vpa:VPA1450 MoxR-related protein. (329 aa) |
| | Tcr_0106 | PFAM: protein kinase; SMART: Serine/threonine protein kinase Sel1-like repeat; KEGG: lpp:lpp1174 hypothetical protein. (454 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa) |
| | Tcr_0128 | PFAM: UvrD/REP helicase; KEGG: stt:t3346 DNA helicase II. (741 aa) |
| | Tcr_0129 | PFAM: ABC transporter related; SMART: ATPase; KEGG: bja:blr8070 probable ATP-binding protein. (202 aa) |
| | Tcr_0179 | ATP-binding cassette superfamily transporter, permease component; PFAM: transport system permease protein; KEGG: gvi:gll0579 hemin ABC transporter permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (326 aa) |
| | hmuV | ATP-binding cassette superfamily transporter, ATP-binding component; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. (258 aa) |
| | Tcr_0188 | Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver sigma-54 factor, interaction region helix-turn-helix, Fis-type; KEGG: mca:MCA2848 nitrogen regulation protein NtrX, putative. (452 aa) |
| | argS | KEGG: mca:MCA3089 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. (592 aa) |
| | Tcr_0202 | Mg chelatase-related protein; KEGG: plu:plu4686 magnesium chelatase family protein; TIGRFAM: Mg chelatase, subunit ChlI; PFAM: magnesium chelatase, ChlI subunit; SMART: ATPase. (511 aa) |
| | Tcr_0207 | Type I secretion system ATPase; PFAM: ABC transporter, transmembrane region ABC transporter related; SMART: ATPase; KEGG: dps:DP0513 related to toxin secretion ATP-binding protein. (734 aa) |
| | rep | ATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (677 aa) |
| | cca | Metal dependent phosphohydrolase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (416 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: mca:MCA2021 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (393 aa) |
| | Tcr_0247 | PFAM: pyruvate kinase; KEGG: vpa:VP2039 pyruvate kinase II; Belongs to the pyruvate kinase family. (480 aa) |
| | Tcr_0251 | Type II secretion pathway protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (484 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (219 aa) |
| | purC | KEGG: mca:MCA0021 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (295 aa) |
| | uvrA | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (935 aa) |
| | Tcr_0334 | Type I site-specific deoxyribonuclease, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1075 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (376 aa) |
| | groS | Chaperonin 10 kDa subunit (groES protein); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa) |
| | groL | Chaperonin 60 kDa subunit (groEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (544 aa) |
| | anmK | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (354 aa) |
| | glyQ | PFAM: glycyl-tRNA synthetase, alpha subunit; KEGG: son:SO0015 glycyl-tRNA synthetase alpha chain. (308 aa) |
| | glyS | KEGG: ecc:c4378 glycyl-tRNA synthetase beta chain. (690 aa) |
| | parE | DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (628 aa) |
| | parC | DNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (742 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa) |
| | ychF | GTP-binding protein, HSR1-related; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (363 aa) |
| | hslU | ATP-dependent hsl protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (440 aa) |
| | clpB | ATPase family associated with various cellular activities; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (854 aa) |
| | Tcr_0423 | CbbQ-m protein; PFAM: ATPase associated with various cellular activities, AAA_5; SMART: ATPase; KEGG: neu:NE1919 nitric oxide reductase NorQ protein. (266 aa) |
| | Tcr_0429 | CbbQ-1 protein; PFAM: ATPase associated with various cellular activities, AAA_5; KEGG: mca:MCA2746 nitric-oxide reductase NorQ protein. (272 aa) |
| | Tcr_0433 | LolD homolog; PFAM: ABC transporter related; SMART: ATPase; KEGG: ppr:PBPRB1124 putative ABC transporter, ATP-binding protein. (233 aa) |
| | purD | KEGG: son:SO0441 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (430 aa) |
| | Tcr_0443 | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha / biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | Tcr_0463 | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (760 aa) |
| | Tcr_0474 | PFAM: PhoH-like protein; KEGG: mca:MCA1458 PhoH family protein. (322 aa) |
| | leuS | TIGRFAM: leucyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase, class Ia; KEGG: pst:PSPTO4812 leucyl-tRNA synthetase. (877 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (209 aa) |
| | Tcr_0494 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase; KEGG: sfx:S0024 putative regulator. (321 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (943 aa) |
| | hldE | D-beta-D-heptose 1-phosphate adenylyltransferase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (480 aa) |
| | glk | Glucokinase; KEGG: gvi:gll1169 glucokinase; TIGRFAM: glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. (320 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (422 aa) |
| | dnaX | DNA polymerase III, tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (696 aa) |
| | Tcr_0536 | KEGG: mca:MCA1677 glutamine synthetase, type I; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region glutamine synthetase, beta-Grasp. (468 aa) |
| | Tcr_0537 | PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ppu:PP5328 phosphate ABC transporter, permease protein. (755 aa) |
| | Tcr_0538 | ATP-binding cassette (ABC) superfamily phosphate transporter, permease component; TIGRFAM: phosphate ABC transporter, inner membrane subunit PstA; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: pae:PA5367 phosphate transport system permease protein. (548 aa) |
| | pstB | ATP-binding cassette (ABC) superfamily phosphate transporter, ATP-binding component; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (272 aa) |
| | Tcr_0544 | ATP-binding cassette (ABC) superfamily phosphate transporter, substrate-binding component; TIGRFAM: phosphate binding protein; KEGG: pae:PA5369 phosphate transport system substrate-binding protein. (322 aa) |
| | Tcr_0550 | ATP-binding cassette (ABC) superfamily transporter, ATP-binding component; PFAM: ABC transporter related; SMART: ATPase; KEGG: pst:PSPTO2267 ABC transporter, ATP-binding protein. (224 aa) |
| | Tcr_0551 | ATP-binding cassette (ABC) superfamily transporter, permease component; PFAM: protein of unknown function DUF214; KEGG: bpa:BPP1688 putative inner membrane transport permease. (823 aa) |
| | Tcr_0554 | TIGRFAM: ATP-dependent helicase HrpB; PFAM: helicase-like helicase-associated region DEAD/DEAH box helicase-like; KEGG: gsu:GSU1838 ATP-dependent helicase HrpB. (848 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (505 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (474 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (449 aa) |
| | Tcr_0575 | ATP-binding cassete (ABC) superfamily transporter, permease component; PFAM: ABC-3; KEGG: atc:AGR_C_2802 permease of ABC zinc transporter ZnuB. (268 aa) |
| | znuC | ATP-binding cassette (ABC) superfamily transporter, ATP-binding component; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (258 aa) |
| | Tcr_0577 | ATP-binding cassette (ABC) superfamily transporter, substrate-binding component; PFAM: periplasmic solute binding protein; KEGG: vch:VC2081 zinc transport system substrate-binding protein; Belongs to the bacterial solute-binding protein 9 family. (301 aa) |
| | Tcr_0580 | KEGG: eca:ECA1861 probable ABC transporter ATP-dependent protein; TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: ATPase. (261 aa) |
| | murC | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (461 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation. (313 aa) |
| | secA | Protein translocase subunit secA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (910 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (197 aa) |
| | Tcr_0595 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II asparagine synthase; KEGG: mpa:MAP1421 asparagine synthetase, glutamine-hydrolyzing. (602 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | hisS | KEGG: pst:PSPTO1435 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S) Anticodon-binding. (426 aa) |
| | Tcr_0672 | PFAM: phage terminase GpA; KEGG: wol:WD0597 prophage LambdaW4, terminase large subunit, putative. (725 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (219 aa) |
| | Tcr_0721 | ATP-binding cassette (ABC) superfamily transporter, ATP-binding component and permease; PFAM: ABC transporter, transmembrane region ABC transporter related; SMART: ATPase; KEGG: vvy:VV1644 ABC-type multidrug transport system, ATPase and permease component. (621 aa) |
| | Tcr_0722 | TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC cadmium-translocating P-type ATPase heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase-like hydrolase E1-E2 ATPase-associated region Hemerythrin HHE cation binding region; KEGG: sme:SMa1163 putative cation transport P-type ATPase. (759 aa) |
| | lysS | TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S) tRNA synthetase, class II (D, K and N) nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: ilo:IL0822 lysyl-tRNA synthetase class II; Belongs to the class-II aminoacyl-tRNA synthetase family. (504 aa) |
| | Tcr_0746 | Flagellar biosynthesis protein FlhG; PFAM: Cobyrinic acid a,c-diamide synthase; KEGG: ppu:PP4342 flagellar number regulator FleN. (297 aa) |
| | Tcr_0764 | DNA translocase FtsK; PFAM: cell divisionFtsK/SpoIIIE; KEGG: ilo:IL0667 DNA segregation ATPase FtsK. (821 aa) |
| | Tcr_0766 | Recombination protein MgsA; PFAM: AAA ATPase, central region; SMART: ATPase; KEGG: pae:PA2613 putative ATPase. (453 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (428 aa) |
| | rhlE | ATP-dependent RNA helicase; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (445 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (284 aa) |
| | Tcr_0806 | TIGRFAM: FolC bifunctional protein; KEGG: xft:PD0854 folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (425 aa) |
| | ftsH | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (651 aa) |
| | Tcr_0866 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (555 aa) |
| | nadK | NAD(+) kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (291 aa) |
| | grpE | GrpE chaparone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] (186 aa) |
| | dnaK | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (638 aa) |
| | dnaJ | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (387 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I Carbamoyl-phosphate synthase, small chain; KEGG: spt:SPA0067 carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (378 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding Carbamoyl-phosphate synthetase large chain, oligomerisation Carbamoyl-phosphate synthetase large chain-like MGS-like; KEGG: pae:PA4756 carbamoylphosphate synthetase large subunit; Belongs to the CarB family. (1070 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (596 aa) |
| | ruvA | Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (200 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (340 aa) |
| | queC | ExsB family protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (232 aa) |
| | ntrC | Nitrogen metabolism transcriptional regulator, NtrC, Fis family; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (487 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: ppu:PP1088 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa) |
| | glnS | KEGG: son:SO1786 glutaminyl-tRNA synthetase; TIGRFAM: glutaminyl-tRNA synthetase; PFAM: glutamyl-tRNA synthetase, class Ic. (559 aa) |
| | cysS | KEGG: mca:MCA0509 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (456 aa) |
| | Tcr_0943 | TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC copper-translocating P-type ATPase heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase-like hydrolase E1-E2 ATPase-associated region; KEGG: hma:pNG6056 copper-transporting ATPase CopA. (670 aa) |
| | Tcr_0948 | DEAD/DEAH box helicase; PFAM: helicase-like DbpA, RNA-binding DEAD/DEAH box helicase-like; KEGG: ppr:PBPRB0212 putative ATP-dependent RNA helicase DbpA; Belongs to the DEAD box helicase family. (468 aa) |
| | Tcr_0950 | KEGG: son:SO2229 ATP-dependent helicase HrpA; TIGRFAM: ATP-dependent helicase HrpA; PFAM: helicase-like helicase-associated region DEAD/DEAH box helicase-like protein of unknown function DUF1605; SMART: ATPase. (1342 aa) |
| | Tcr_0955 | S16-family peptidase; KEGG: pst:PSPTO4585 ATP-dependent protease, putative. (797 aa) |
| | lpxK | lipid-A-disaccharide synthase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (335 aa) |
| | Tcr_0973 | PFAM: ABC transporter related; SMART: ATPase; KEGG: vpa:VP2669 ABC transporter, ATP-binding protein. (240 aa) |
| | Tcr_0979 | ATP-binding cassette (ABC) superfamily transporter, ATP-binding component; PFAM: ABC transporter related; SMART: ATPase; KEGG: son:SO3954 ABC transporter, ATP-binding protein, putative. (265 aa) |
| | Tcr_0980 | ATP-binding cassette (ABC) superfamily transporter, permease component; PFAM: protein of unknown function DUF140; KEGG: eca:ECA0296 putative membrane protein. (261 aa) |
| | Tcr_0981 | ATP-binding cassette (ABC) superfamily transporter, solute-binding component; PFAM: Mammalian cell entry related; KEGG: mca:MCA1967 putative ABC transport system substrate-binding protein. (158 aa) |
| | Tcr_0982 | ATP-binding cassette (ABC) superfamily transporter, solute-binding component; PFAM: toluene tolerance; KEGG: bps:BPSL3146 putative toluene tolerance protein. (214 aa) |
| | Tcr_0984 | ATP-binding cassette (ABC) superfamily transporter, ATP-binding component; PFAM: ABC transporter related; SMART: ATPase; KEGG: eba:ebA1306 ATP-binding ABC transporter protein. (308 aa) |
| | Tcr_0985 | ATP-binding cassette (ABC) superfamily transporter, permease component; PFAM: ABC-2; KEGG: probable transmembrane protein. (255 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (208 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (457 aa) |
| | Tcr_1015 | PFAM: helicase-like DEAD/DEAH box helicase-like; KEGG: vfi:VF1790 ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (393 aa) |
| | selD | Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (359 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (680 aa) |
| | Tcr_1042 | Conserved hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (374 aa) |
| | purM | KEGG: ppr:PBPRA2910 putative phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein AIR synthase related protein-like. (347 aa) |
| | Tcr_1065 | TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: cation transporting ATPase-like Haloacid dehalogenase-like hydrolase E1-E2 ATPase-associated region; KEGG: mac:MA4378 sodium/potassium-transporting ATPase, alpha subunit. (892 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (572 aa) |
| | mutL | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (630 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (324 aa) |
| | mnmA | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (379 aa) |
| | Tcr_1107 | RimK family protein; TIGRFAM: alpha-L-glutamate ligase-like protein; KEGG: vfi:VF0944 glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase). (314 aa) |
| | Tcr_1112 | ATP-dependent Clp protease ATP-binding subunit ClpA; PFAM: AAA ATPase, central region Clp, N terminal; SMART: ATPase; KEGG: mca:MCA1789 ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. (748 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (653 aa) |
| | Tcr_1134 | ATP-binding cassette (ABC) superfamily transporter, ATPase component; PFAM: ABC transporter related; SMART: ATPase; KEGG: bbr:BB2382 probable ABC transporter ATP-binding protein. (651 aa) |
| | Tcr_1135 | ATP-binding cassette (ABC) superfamily transporter, permease component; PFAM: ABC-2; KEGG: mca:MCA0555 ABC transporter, ATP-binding/permease protein. (384 aa) |
| | Tcr_1136 | ATP-binding cassette (ABC) superfamily transporter, permease component; PFAM: ABC-2; KEGG: atc:AGR_L_429 probable permease of ABC transporter. (381 aa) |
| | Tcr_1153 | ATP-binding cassette (ABC) superfamily nitrate transporter, substrate-binding component; TIGRFAM: Twin-arginine translocation pathway signal; KEGG: vvy:VVA0951 nitrate transporter system, periplasmic component. (461 aa) |
| | Tcr_1154 | ATP-binding cassette (ABC) superfamily nitrate transporter, permease component; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: vvy:VVA0950 nitrate transporter system, permease component. (332 aa) |
| | Tcr_1155 | ATP-binding cassette (ABC) superfamily nitrate transporter, ATP-binding component; KEGG: vvy:VVA0949 nitrate transporter system, ATPase component; TIGRFAM: nitrate ABC transporter, ATPase subunits C and D; PFAM: ABC transporter related; SMART: ATPase. (264 aa) |
| | Tcr_1165 | TIGRFAM: septum site-determining protein MinD; PFAM: Cobyrinic acid a,c-diamide synthase; KEGG: vvy:VV1056 septum formation inhibitor-activating ATPase. (270 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1159 aa) |
| | lolD | Lipoprotein releasing system, ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (230 aa) |
| | Tcr_1174 | ABC transporter ATP-binding protein homolog; PFAM: ABC transporter related; SMART: ATPase; KEGG: yps:YPTB3716 putative ABC transporter with fused ATP-binding domains. (654 aa) |
| | clpX | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (416 aa) |
| | lon1 | Lon-A peptidase. Serine peptidase. MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (815 aa) |
| | Tcr_1182 | ATP-binding cassette (ABC) superfamily transporter, substrate-binding component; PFAM: extracellular solute-binding protein, family 5; KEGG: neu:NE1152 bacterial extracellular solute-binding protein, family 5. (709 aa) |
| | Tcr_1183 | ATP-binding cassette (ABC) superfamily transporter, permease component; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eba:ebA6661 oligopeptide transport system permease protein OppB. (325 aa) |
| | Tcr_1184 | ATP-binding cassette (ABC) superfamily transporter, permease component; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: neu:NE2479 oligopeptide ABC transporter. (457 aa) |
| | Tcr_1185 | ATP-binding cassette (ABC) superfamily transporter, ATP-binding component; PFAM: ABC transporter related; SMART: ATPase; KEGG: mca:MCA1268 peptide ABC transporter, ATP-binding protein; Belongs to the ABC transporter superfamily. (547 aa) |
| | Tcr_1186 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (804 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (871 aa) |
| | cmk | KEGG: hdu:HD1351 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (221 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (470 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa) |
| | tilS | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (420 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa) |
| | Tcr_1269 | Conserved hypothetical protein with a helicase c2 domain; SMART: Helicase c2; KEGG: mca:MCA1991 ATP-dependent helicase, putative. (636 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (236 aa) |
| | Tcr_1298 | ATP-binding cassette superfamily transporter, permease component; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: btk:BT9727_4232 oligopeptide transport system, permease. (272 aa) |
| | Tcr_1299 | PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ttj:TTHA1337 peptide ABC transporter, permease protein. (307 aa) |
| | Tcr_1303 | ATP-binding cassette (ABC) superfamily transporter, solute-binding component; PFAM: extracellular solute-binding protein, family 5; KEGG: oih:OB0773 oligopeptide ABC transporter oligopeptide-binding protein. (504 aa) |
| | Tcr_1360 | Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (473 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (545 aa) |
| | sucC | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (390 aa) |
| | Tcr_1380 | cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (204 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa) |
| | nrdR | Conserved hypothetical protein containing DUF193; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (154 aa) |
| | Tcr_1403 | PFAM: ABC transporter related; SMART: ATPase; KEGG: msu:MS1240 Uup protein. (556 aa) |
| | Tcr_1439 | Flagellar biosynthesis ATPase FliI; KEGG: pae:PA1104 flagellum-specific ATP synthase FliI; TIGRFAM: ATPase, FliI/YscN family; PFAM: H+-transporting two-sector ATPase, alpha/beta subunit, central region; SMART: ATPase. (446 aa) |
| | Tcr_1444 | Two component, sigma54 specific, transcriptional regulator, Fis family; PFAM: response regulator receiver sigma-54 factor, interaction region helix-turn-helix, Fis-type; SMART: ATPase; KEGG: vfi:VF1854 FlrC; two-component response regulator. (459 aa) |
| | Tcr_1446 | Sigma54 specific transcriptional regulator, Fis family; PFAM: sigma-54 factor, interaction region helix-turn-helix, Fis-type; SMART: ATPase; KEGG: lpp:lpp0915 transcriptional regulator FleQ. (366 aa) |
| | thiI | Thiamine biosynthesis protein thiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (478 aa) |
| | glnE | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] (911 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (924 aa) |
| | msbA | Lipid A export ATP-binding/permease protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (581 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa) |
| | Tcr_1527 | KEGG: vvu:VV11644 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (170 aa) |
| | pcnB | poly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (484 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (334 aa) |
| | lon2 | PIM1 peptidase. Serine peptidase. MEROPS family S16; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (878 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1292 aa) |
| | Tcr_1554 | PFAM: PhoH-like protein; SMART: Nucleotide binding protein, PINc; KEGG: mca:MCA0663 PhoH family protein. (469 aa) |
| | Tcr_1562 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: yps:YPTB3188 putative methenyl-THF synthetase-family protein (MTHFS). (192 aa) |
| | mpl | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (458 aa) |
| | Tcr_1589 | KEGG: pst:PSPTO1843 aspartate kinase, monofunctional class; TIGRFAM: aspartate kinase aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase amino acid-binding ACT; Belongs to the aspartokinase family. (408 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (864 aa) |
| | recA | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (347 aa) |
| | mutS | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (871 aa) |
| | Tcr_2187 | Two component, sigma54 specific, transcriptional regulator, Fis family; KEGG: mca:MCA1713 sigma-54 dependent DNA-binding response regulator; TIGRFAM: Helix-turn-helix, Fis-type; PFAM: response regulator receiver sigma-54 factor, interaction region; SMART: ATPase. (456 aa) |
| | gshB | KEGG: ppr:PBPRB1479 putative Glutathione synthase; Ribosomal protein S6 modification enzyme; Belongs to the prokaryotic GSH synthase family. (350 aa) |
| | Tcr_1599 | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (126 aa) |
| | Tcr_1606 | ABC transporter ATP-binding protein homolog; PFAM: ABC transporter related; SMART: ATPase; KEGG: eca:ECA3010 ABC transporter ATP-binding protein. (528 aa) |
| | htpG | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. (630 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (526 aa) |
| | gatB | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (475 aa) |
| | gatA | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (484 aa) |
| | gatC | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (95 aa) |
| | Tcr_1630 | TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl; KEGG: son:SO4098 rod shape-determining protein MreB. (348 aa) |
| | pheT | KEGG: sfx:S1635 phenylalanine tRNA synthetase, beta-subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit. (793 aa) |
| | pheS | KEGG: sfx:S1634 phenylalanine tRNA synthetase, alpha-subunit; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase, class IIc aminoacyl tRNA synthetase, class II-like; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (332 aa) |
| | thrS | threonyl-tRNA synthetase / Ser-tRNA(Thr) hydrolase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (642 aa) |
| | Tcr_1672 | PFAM: ATP dependent DNA ligase; KEGG: msu:MS0939 ATP-dependent DNA ligase. (266 aa) |
| | Tcr_1697 | PFAM: UvrD/REP helicase; KEGG: neu:NE2166 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1182 aa) |
| | Tcr_1732 | PFAM: GHMP kinase; KEGG: mevalonate kinase, putative. (349 aa) |
| | Tcr_1733 | PFAM: GHMP kinase; KEGG: phosphomevalonate kinase, putative. (295 aa) |
| | Tcr_1734 | KEGG: mvaD; diphosphomevalonate decarboxylase; TIGRFAM: diphosphomevalonate decarboxylase; PFAM: GHMP kinase. (332 aa) |
| | Tcr_1740 | Truncated lysyl-tRNA synthetase GenX; PFAM: tRNA synthetase, class II (D, K and N); KEGG: spt:SPA4161 lysyl-tRNA synthetase. (324 aa) |
| | Tcr_1750 | Pilus retraction ATPase PilT; KEGG: son:SO3351 twitching motility protein PilT; TIGRFAM: twitching motility protein; PFAM: type II secretion system protein E; SMART: ATPase. (345 aa) |
| | uvrB | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (678 aa) |
| | Tcr_1761 | ABC transporter ATP-binding protein homolog; PFAM: ABC transporter related; SMART: ATPase; KEGG: gsu:GSU0913 ABC transporter, ATP-binding protein. (642 aa) |
| | Tcr_1768 | KEGG: mac:MA3268 ribosomal protein S6 modification protein. (302 aa) |
| | Tcr_1787 | ATP-binding cassette (ABC) superfamily transporter, permease component; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: bja:blr6247 ABC transporter permease protein. (326 aa) |
| | Tcr_1788 | ATP-binding cassette (ABC) superfamily transporter, ATP-binding component; PFAM: ABC transporter related; SMART: ATPase; KEGG: mja:MJ0412 putative taurine transport system ATP-binding protein. (303 aa) |
| | Tcr_1792 | TIGRFAM: urea amidolyase related protein; PFAM: biotin/lipoyl attachment Allophanate hydrolase subunit 2 Allophanate hydrolase subunit 1 Carbamoyl-phosphate synthase L chain, ATP-binding Carbamoyl-phosphate synthetase large chain-like biotin carboxylase-like; KEGG: neu:NE2420 biotin / lipoyl attachment:carbamoyl-phosphate synthase:DUF183. (1206 aa) |
| | nnrE | YjeF family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] (490 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (369 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (385 aa) |
| | gshB-2 | KEGG: mca:MCA2338 glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: glutathione synthetase-like glutathione synthetase, ATP-binding; Belongs to the prokaryotic GSH synthase family. (321 aa) |
| | Tcr_1883 | ATP-dependent RNA helicase; PFAM: helicase-like DEAD/DEAH box helicase-like; KEGG: son:SO0947 ATP-dependent RNA helicase SrmB; Belongs to the DEAD box helicase family. (401 aa) |
| | ppk | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (703 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (304 aa) |
| | Tcr_1923 | TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: cation transporting ATPase-like Haloacid dehalogenase-like hydrolase E1-E2 ATPase-associated region; KEGG: bha:BH2515 cation-transporting ATPase. (898 aa) |
| | modC | ATP-binding cassette (ABC) superfamily molybdenum transporter, ATP-binding component; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. (358 aa) |
| | Tcr_1926 | ATP-binding cassette (ABC) superfamily molybdenum transporter, permease component; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (231 aa) |
| | Tcr_1927 | ATP-binding cassette superfamily transporter, molybdate-binding component; TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding protein; PFAM: extracellular solute-binding protein, family 1; KEGG: rpa:RPA4717 molybdate transport system substrate-binding protein. (253 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | coaX | Putative transcriptional acitvator, Baf; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (248 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (398 aa) |
| | Tcr_1960 | TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC copper-translocating P-type ATPase heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase-like hydrolase Heavy metal transport/detoxification protein E1-E2 ATPase-associated region; KEGG: son:SO2359 cation transport ATPase, E1-E2 family. (828 aa) |
| | hisE | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mca:MCA2800 phosphoribosyl-ATP pyrophosphatase. (113 aa) |
| | priA | Replication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (774 aa) |
| | Tcr_1996 | TIGRFAM: ATP-dependent DNA helicase, RecQ family ATP-dependent DNA helicase RecQ; PFAM: helicase-like HRDC DEAD/DEAH box helicase-like; KEGG: recQ; ATP-dependent DNA helicase RecQ. (629 aa) |
| | deaD | DEAD/DEAH box helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (574 aa) |
| | selO | Conserved hypothetical protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). (481 aa) |
| | Tcr_2023 | ATP-binding cassette (ABC) superfamily periplasmic substrate binding component homolog; KEGG: gvi:gll0175 ABC transport system substrate-binding protein. (294 aa) |
| | tmcA | Conserved hypothetical protein with DUF699; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (712 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa) |
| | rimK | SSU ribosomal protein S6P modification protein; TIGRFAM: alpha-L-glutamate ligases, RimK family; PFAM: ATP-dependent carboxylate-amine ligase-like, ATP-grasp; KEGG: vch:VC2281 ribosomal protein S6 modification protein. (301 aa) |
| | Tcr_2068 | PAS/PAC sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: PAS domain containing protein+B6621 response regulator receiver GAF ATP-binding region, ATPase-like histidine kinase A-like; KEGG: gka:GK1468 hypothetical protein. (948 aa) |
| | Tcr_2079 | ATP-binding cassette (ABC) superfamily phosphonate transporter, solute-binding component; TIGRFAM: phosphonate ABC transporter, periplasmic phosphonate-binding protein; KEGG: ana:all8089 putative phosphonate transport system substrate-binding protein. (305 aa) |
| | phnC | ATP-binding cassette (ABC) superfamily phosphonate transporter, ATP-binding component; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. (272 aa) |
| | Tcr_2081 | ATP-binding cassette (ABC) superfamily phosphonate transporter, permease component; TIGRFAM: phosphonate ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ccr:CC0363 phosphonates ABC transporter, permease protein. (335 aa) |
| | Tcr_2086 | ABC transporter ATP-binding component homolog; PFAM: ABC transporter related; SMART: ATPase; KEGG: oih:OB0972 phosphonate ABC transporter ATP-binding protein. (278 aa) |
| | Tcr_2087 | ABC transporter ATP-binding component homolog; KEGG: ypm:YP0621 phosphonates transport ATP-binding protein; TIGRFAM: phosphonate C-P lyase system protein PhnL; PFAM: ABC transporter related; SMART: ATPase. (244 aa) |
| | phnN | Phosphonate metabolism accessory protein; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (195 aa) |
| | Tcr_2110 | P-type ATPase (P-ATPase) superfamily cation transporter; KEGG: bja:bll0700 heavy-metal transporting P-type ATPase; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC copper-translocating P-type ATPase heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase-like hydrolase YHS E1-E2 ATPase-associated region; SMART: TRASH. (776 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa) |
| | Tcr_2146 | ATP-binding cassette (ABC) superfamily transporter, permease component; PFAM: ABC-3; KEGG: sth:STH1509 ABC transporter permease protein. (295 aa) |
| | Tcr_2147 | ATP-binding cassette (ABC) superfamily transporter, permease component; PFAM: iron dependent repressor ABC-3; KEGG: bsu:BG13853 manganese transport system permease protein. (466 aa) |
| | Tcr_2148 | ATP-binding cassette (ABC) superfamily transporter, ATP-binding component; PFAM: ABC transporter related; SMART: ATPase; KEGG: sth:STH1507 ABC transporter ATP-binding protein. (263 aa) |
| | Tcr_2149 | ATP-binding cassette (ABC) superfamily transporter, solute-binding component; PFAM: periplasmic solute binding protein; KEGG: sth:STH1506 ABC transporter permease protein; Belongs to the bacterial solute-binding protein 9 family. (300 aa) |
| | recG | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (690 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (144 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (459 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
