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| | DFI_08390 | Acetolactate synthase small subunit. (207 aa) |
| | ilvC | Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (336 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (521 aa) |
| | lysJ | [LysW]-aminoadipate semialdehyde transaminase; Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (416 aa) |
| | kynB | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. (206 aa) |
| | valS | Valine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (917 aa) |
| | gltX | Glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (477 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (351 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (428 aa) |
| | DFI_08895 | Aminoglycoside phosphotransferase. (325 aa) |
| | hutH | Histidine ammonia-lyase. (500 aa) |
| | hutI | Imidazolonepropionase. (399 aa) |
| | DFI_08945 | Agmatinase; Belongs to the arginase family. (308 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (559 aa) |
| | DFI_08965 | Aspartate aminotransferase family protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa) |
| | DFI_08970 | Lysine 2,3-aminomutase. (486 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | DFI_08990 | Glutamine amidotransferase. (209 aa) |
| | folD-2 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (475 aa) |
| | DFI_09310 | Proline dehydrogenase. (310 aa) |
| | DFI_09315 | L-glutamate gamma-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (523 aa) |
| | DFI_09345 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (390 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | proS-2 | Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacy [...] (594 aa) |
| | DFI_09485 | Carboxynorspermidine decarboxylase. (430 aa) |
| | hisI | Histidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. (221 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (382 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (203 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (352 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa) |
| | DFI_09990 | Type I glutamate--ammonia ligase; Belongs to the glutamine synthetase family. (454 aa) |
| | ilvA | L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (519 aa) |
| | DFI_10285 | Cysteine desulfurase-like protein. (399 aa) |
| | proS | Proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (497 aa) |
| | glyQS | Glycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (504 aa) |
| | DFI_10530 | Methylcrotonoyl-CoA carboxylase. (560 aa) |
| | tpl | Tyrosine phenol-lyase. (471 aa) |
| | tnaA | Tryptophanase; Belongs to the beta-eliminating lyase family. (468 aa) |
| | thrS | Threonine--tRNA ligase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (649 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (370 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (212 aa) |
| | DFI_10835 | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (229 aa) |
| | dtd | D-aminoacyl-tRNA deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (360 aa) |
| | DFI_11270 | Cysteine synthase. (416 aa) |
| | DFI_11375 | Peptidase M20. (451 aa) |
| | DFI_11390 | Pyruvate carboxyltransferase. (431 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (249 aa) |
| | pheT | Phenylalanine--tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (821 aa) |
| | pheS | Phenylalanine--tRNA ligase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (339 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (408 aa) |
| | DFI_12230 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (346 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (306 aa) |
| | DFI_12245 | L-asparaginase. (329 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (157 aa) |
| | DFI_12865 | Glutamine--tRNA ligase. (801 aa) |
| | DFI_13055 | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (408 aa) |
| | DFI_13110 | Methionine gamma-lyase. (396 aa) |
| | glmS | Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (606 aa) |
| | lysS | Lysine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (517 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (394 aa) |
| | DFI_13440 | GNAT family N-acetyltransferase. (177 aa) |
| | DFI_13445 | GNAT family N-acetyltransferase. (163 aa) |
| | argH | Argininosuccinate lyase. (468 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa) |
| | DFI_13485 | Aminotransferase. (375 aa) |
| | DFI_13560 | Sulfurtransferase. (285 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (201 aa) |
| | DFI_13665 | 2-oxoisovalerate dehydrogenase. (369 aa) |
| | DFI_13670 | Alpha-ketoacid dehydrogenase subunit beta. (339 aa) |
| | tyrS | Tyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (431 aa) |
| | DFI_00080 | GNAT family N-acetyltransferase. (309 aa) |
| | DFI_00100 | Branched-chain amino acid dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (343 aa) |
| | DFI_00360 | Glutathione-dependent formaldehyde dehydrogenase. (392 aa) |
| | carB | Carbamoyl-phosphate synthase large chain. (1033 aa) |
| | DFI_00645 | Tryptophan--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (342 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (472 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit PurQ; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (221 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (242 aa) |
| | DFI_01385 | APH domain-containing protein. (121 aa) |
| | GCA_000419625_00870 | annotation not available (96 aa) |
| | gcvP | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (952 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (121 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (356 aa) |
| | DFI_01660 | N-acyl-L-amino acid amidohydrolase. (392 aa) |
| | DFI_01685 | Deaminase. (176 aa) |
| | DFI_01700 | Arginase; Belongs to the arginase family. (299 aa) |
| | DFI_01895 | N-carbamoylputrescine amidase. (298 aa) |
| | DFI_01930 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (167 aa) |
| | DFI_02050 | Histidinol phosphate aminotransferase. (334 aa) |
| | cbiA | Cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (438 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | DFI_02270 | 2-aminoadipate aminotransferase. (382 aa) |
| | DFI_02320 | Aspartate ammonia-lyase. (478 aa) |
| | speA | Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (639 aa) |
| | DFI_06540 | Serine-tRNA(Ala) deacylase AlaX. (406 aa) |
| | DFI_02490 | Glutamate synthase subunit alpha. (1598 aa) |
| | gltD | Glutamate synthase. (488 aa) |
| | DFI_02685 | APH domain-containing protein. (340 aa) |
| | DFI_02770 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (434 aa) |
| | DFI_02775 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (417 aa) |
| | GCA_000419625_03624 | annotation not available (379 aa) |
| | DFI_17520 | Cysteine desulfurase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (411 aa) |
| | DFI_17380 | Homoserine acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (370 aa) |
| | DFI_17095 | Ferredoxin--nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (529 aa) |
| | DFI_17055 | Sulfurtransferase. (105 aa) |
| | DFI_18085 | Asparagine synthetase B. (624 aa) |
| | DFI_18005 | Gamma-glutamyl-gamma-aminobutyrate hydrolase. (234 aa) |
| | DFI_17830 | Aminotransferase. (533 aa) |
| | DFI_17735 | Uncharacterized protein. (360 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (418 aa) |
| | kynA | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (290 aa) |
| | DFI_17650 | Ornithine--oxo-acid transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (411 aa) |
| | DFI_14640 | Uncharacterized protein. (327 aa) |
| | DFI_15085 | Peptidase M20. (447 aa) |
| | DFI_15310 | Argininosuccinate lyase. (484 aa) |
| | DFI_15665 | N-acetyltransferase domain-containing protein. (329 aa) |
| | DFI_16030 | Dihydrodipicolinate synthase family protein; Belongs to the DapA family. (307 aa) |
| | DFI_16080 | Zn-dependent hydrolase. (306 aa) |
| | GCA_000419625_03002 | annotation not available (105 aa) |
| | DFI_16085 | Diaminopropionate ammonia-lyase. (385 aa) |
| | DFI_16090 | Acetylornithine deacetylase. (377 aa) |
| | DFI_16215 | Uncharacterized protein. (315 aa) |
| | GCA_000419625_02967 | annotation not available (74 aa) |
| | DFI_13745 | Methionine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (518 aa) |
| | DFI_13965 | Homocysteine S-methyltransferase. (314 aa) |
| | DFI_14265 | Uncharacterized protein. (183 aa) |
| | DFI_14315 | N-acetyltransferase domain-containing protein. (157 aa) |
| | DFI_05885 | Flavin monoamine oxidase. (532 aa) |
| | cysS | Cysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (491 aa) |
| | DFI_05920 | Peptidase M20. (451 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (544 aa) |
| | leuS | Leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (826 aa) |
| | DFI_06045 | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (265 aa) |
| | mqnB | Futalosine hydrolase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (219 aa) |
| | DFI_06405 | Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (261 aa) |
| | DFI_06420 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (340 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (311 aa) |
| | DFI_06480 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (359 aa) |
| | DFI_02840 | Carboxypeptidase. (377 aa) |
| | DFI_02870 | Serine--tRNA ligase. (425 aa) |
| | DFI_03100 | Alanine dehydrogenase; Belongs to the AlaDH/PNT family. (369 aa) |
| | lysK | [LysW]-lysine hydrolase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine. (376 aa) |
| | tdh | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (363 aa) |
| | DFI_03810 | Membrane protein. (218 aa) |
| | guaA | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (505 aa) |
| | DFI_03925 | Homoserine dehydrogenase. (320 aa) |
| | panD | Aspartate 1-decarboxylase alpha chain; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa) |
| | DFI_04065 | Bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase. (361 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (380 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (440 aa) |
| | DFI_04640 | O-acetylhomoserine aminocarboxypropyltransferase. (456 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (345 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa) |
| | DFI_04885 | Sulfurtransferase. (290 aa) |
| | alaS | Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (878 aa) |
| | DFI_05165 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (297 aa) |
| | DFI_05170 | Serine acetyltransferase. (276 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (363 aa) |
| | metG | Methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (666 aa) |
| | trpS | Tryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (332 aa) |
| | DFI_05685 | Isocitrate dehydrogenase. (333 aa) |
| | DFI_06655 | Shikimate dehydrogenase. (254 aa) |
| | DFI_06665 | Prephenate dehydrogenase. (374 aa) |
| | gluQ | Glutamyl-Q tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (298 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (416 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (275 aa) |
| | ileS | Isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1063 aa) |
| | pdxS | Pyridoxal 5'-phosphate synthase subunit PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (295 aa) |
| | pdxT | Pyridoxal 5'-phosphate synthase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa) |
| | DFI_06850 | Aminotransferase class V. (387 aa) |
| | hisS | Histidine--tRNA ligase. (441 aa) |
| | aspS-2 | Aspartate--tRNA ligase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (580 aa) |
| | DFI_06940 | Aspartokinase; Belongs to the aspartokinase family. (475 aa) |
| | DFI_06965 | Pyrimidine reductase. (182 aa) |
| | asnS | Asparagine--tRNA ligase. (444 aa) |
| | DFI_07035 | Aspartate aminotransferase family protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (485 aa) |
| | DFI_07055 | Lysine biosynthesis enzyme LysX; Belongs to the RimK family. (288 aa) |
| | DFI_07070 | Homoaconitate hydratase; Belongs to the LeuD family. (167 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa) |
| | DFI_07150 | Aminotransferase V. (393 aa) |
| | DFI_07155 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (547 aa) |
| | argS | Arginine--tRNA ligase. (615 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ alpha chain; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (401 aa) |
| | aspS | Aspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (452 aa) |
| | aroE | Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (287 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (576 aa) |
| | lysZ | [LysW]-aminoadipate kinase; Catalyzes the phosphorylation of LysW-gamma-alpha- aminoadipate; Belongs to the acetylglutamate kinase family. LysZ subfamily. (267 aa) |
| | lysY | [LysW]-L-2-aminoadipate 6-phosphate reductase; Catalyzes the NADPH-dependent reduction of [LysW]- aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (347 aa) |
| | DFI_07750 | Bifunctional chorismate mutase/prephenate dehydratase. (295 aa) |
| | DFI_07780 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1221 aa) |
| | DFI_07785 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (249 aa) |
| | DFI_07875 | L-glutamate gamma-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (525 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (263 aa) |
| | DFI_07960 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (354 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (196 aa) |
| | DFI_08055 | Enolase; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (372 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (431 aa) |
| | DFI_08385 | Acetolactate synthase. (574 aa) |
