STRINGSTRING
GCA_000419625_01411 GCA_000419625_01411 murE murE DFI_13225 DFI_13225 DFI_13420 DFI_13420 DFI_13530 DFI_13530 prfB prfB DFI_00145 DFI_00145 DFI_00250 DFI_00250 priA priA DFI_00735 DFI_00735 DFI_01125 DFI_01125 DFI_01245 DFI_01245 DFI_01530 DFI_01530 DFI_01760 DFI_01760 DFI_01765 DFI_01765 murI murI DFI_02300 DFI_02300 DFI_02305 DFI_02305 DFI_02380 DFI_02380 DFI_02535 DFI_02535 mltG mltG rsfS rsfS DFI_02815 DFI_02815 recD2 recD2 DFI_05295 DFI_05295 DFI_05045 DFI_05045 DFI_04880 DFI_04880 DFI_04590 DFI_04590 DFI_03990 DFI_03990 DFI_03985 DFI_03985 DFI_03980 DFI_03980 DFI_03975 DFI_03975 ccmE ccmE prfA prfA DFI_03875 DFI_03875 DFI_03835 DFI_03835 murD murD rplT rplT DFI_03415 DFI_03415 ddl ddl murA murA DFI_02905 DFI_02905 GCA_000419625_03869 GCA_000419625_03869 GCA_000419625_03868 GCA_000419625_03868 GCA_000419625_03860 GCA_000419625_03860 GCA_000419625_03848 GCA_000419625_03848 GCA_000419625_03818 GCA_000419625_03818 GCA_000419625_03774 GCA_000419625_03774 GCA_000419625_03696 GCA_000419625_03696 DFI_19450 DFI_19450 GCA_000419625_03603 GCA_000419625_03603 DFI_16995 DFI_16995 DFI_18010 DFI_18010 DFI_15320 DFI_15320 DFI_15685 DFI_15685 GCA_000419625_03031 GCA_000419625_03031 DFI_16185 DFI_16185 DFI_16510 DFI_16510 DFI_13780 DFI_13780 ruvA ruvA mfd mfd glmU glmU frr frr DFI_06575 DFI_06575 DFI_06995 DFI_06995 DFI_07000 DFI_07000 DFI_07050 DFI_07050 DFI_07130 DFI_07130 GCA_000419625_02491 GCA_000419625_02491 DFI_07420 DFI_07420 DFI_07565 DFI_07565 uppP uppP DFI_07655 DFI_07655 recG recG murG murG murC murC murB murB DFI_08285 DFI_08285 ftsZ ftsZ mraY mraY ruvB ruvB DFI_08600 DFI_08600 gyrA gyrA DFI_09025 DFI_09025 DFI_09130 DFI_09130 DFI_09160 DFI_09160 smc smc DFI_09450 DFI_09450 DFI_09580 DFI_09580 DFI_09590 DFI_09590 topA topA DFI_09675 DFI_09675 DFI_09820 DFI_09820 prfC prfC DFI_09910 DFI_09910 DFI_09925 DFI_09925 DFI_09930 DFI_09930 DFI_10245 DFI_10245 DFI_10505 DFI_10505 DFI_10955 DFI_10955 mscL mscL DFI_11145 DFI_11145 DFI_11445 DFI_11445 DFI_11570 DFI_11570 DFI_11635 DFI_11635 DFI_11775 DFI_11775 DFI_11780 DFI_11780 DFI_11785 DFI_11785 DFI_11870 DFI_11870 DFI_12070 DFI_12070 DFI_12105 DFI_12105 argR argR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GCA_000419625_01411annotation not available (1620 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (493 aa)
DFI_13225Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (448 aa)
DFI_13420Topoisomerase I. (346 aa)
DFI_13530Uncharacterized protein. (151 aa)
prfBPeptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (377 aa)
DFI_00145DNA-binding protein; Belongs to the bacterial histone-like protein family. (124 aa)
DFI_00250Elongation factor G. (668 aa)
priAProbable primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (842 aa)
DFI_00735ATP-dependent helicase. (883 aa)
DFI_01125RNA-binding protein. (196 aa)
DFI_01245Twitching motility protein PilT. (361 aa)
DFI_01530AAA family ATPase. (429 aa)
DFI_01760OstA family protein. (345 aa)
DFI_01765OstA-like_N domain-containing protein. (301 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (279 aa)
DFI_02300Fe-S cluster assembly protein SufD. (450 aa)
DFI_02305Fe-S cluster assembly protein SufB. (468 aa)
DFI_02380Uncharacterized protein. (936 aa)
DFI_02535RNA helicase; Belongs to the DEAD box helicase family. (532 aa)
mltGEndolytic murein transglycosylase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (343 aa)
rsfSRibosomal silencing factor RsfS; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (133 aa)
DFI_02815LytR family transcriptional regulator. (446 aa)
recD2ATP-dependent RecD-like DNA helicase; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (714 aa)
DFI_05295DNA helicase. (738 aa)
DFI_05045ATPase. (599 aa)
DFI_04880Cysteine desufuration protein SufE. (148 aa)
DFI_04590Penicillin-binding protein. (449 aa)
DFI_03990Cytochrome C biogenesis protein CcdA. (226 aa)
DFI_03985ABC transporter ATP-binding protein. (235 aa)
DFI_03980Heme ABC transporter permease CcmB. (229 aa)
DFI_03975Cytochrome C assembly protein. (239 aa)
ccmECytochrome c-type biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (156 aa)
prfAPeptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (368 aa)
DFI_03875Type IV pili twitching motility protein PilT. (358 aa)
DFI_03835Iron-sulfur cluster carrier protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (349 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (434 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa)
DFI_03415Folate-binding protein YgfZ; Belongs to the GcvT family. (297 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (339 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (426 aa)
DFI_02905Twitching motility protein PilT. (424 aa)
GCA_000419625_03869annotation not available (243 aa)
GCA_000419625_03868annotation not available (721 aa)
GCA_000419625_03860annotation not available (363 aa)
GCA_000419625_03848annotation not available (233 aa)
GCA_000419625_03818annotation not available (623 aa)
GCA_000419625_03774annotation not available (223 aa)
GCA_000419625_03696annotation not available (122 aa)
DFI_19450DNA helicase RecQ. (908 aa)
GCA_000419625_03603annotation not available (371 aa)
DFI_16995GGDEF domain-containing protein. (364 aa)
DFI_18010DNA-binding protein; Belongs to the bacterial histone-like protein family. (124 aa)
DFI_15320GGDEF domain-containing protein. (361 aa)
DFI_15685Uncharacterized protein. (677 aa)
GCA_000419625_03031annotation not available (466 aa)
DFI_16185GGDEF domain-containing protein. (368 aa)
DFI_16510GGDEF domain-containing protein. (364 aa)
DFI_13780GNAT family N-acetyltransferase. (267 aa)
ruvAHolliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (199 aa)
mfdTranscription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1054 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (490 aa)
frrRibosome-recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (183 aa)
DFI_06575Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase. (387 aa)
DFI_06995Translational GTPase TypA. (593 aa)
DFI_07000DNA helicase RecQ. (762 aa)
DFI_07050Metal-sulfur cluster biosynthetic enzyme. (119 aa)
DFI_07130Outer membrane chaperone OmpH. (159 aa)
GCA_000419625_02491annotation not available (165 aa)
DFI_07420RNA-binding protein. (79 aa)
DFI_07565Septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization. (201 aa)
uppPUndecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (275 aa)
DFI_07655Stage V sporulation protein S. (97 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (778 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (396 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (481 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (316 aa)
DFI_08285Cell division protein FtsQ; Essential cell division protein. (242 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (355 aa)
mraYPhospho-N-acetylmuramoyl-pentapeptide-transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (309 aa)
ruvBHolliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
DFI_08600DNA topoisomerase (ATP-hydrolyzing). (679 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (811 aa)
DFI_09025NADH dehydrogenase subunit. (129 aa)
DFI_09130Uncharacterized protein. (213 aa)
DFI_09160DNA helicase. (1117 aa)
smcChromosome partition protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1098 aa)
DFI_09450Uncharacterized protein. (895 aa)
DFI_09580ATP-dependent protease. (499 aa)
DFI_09590Cysteine desulfurase NifS. (377 aa)
topADNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (968 aa)
DFI_09675Murein biosynthesis integral membrane protein MurJ. (552 aa)
DFI_09820Iron-sulfur cluster scaffold-like protein. (153 aa)
prfCPeptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (533 aa)
DFI_09910UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. (433 aa)
DFI_09925Fimbrial assembly protein. (229 aa)
DFI_09930Pilus assembly protein PilO. (213 aa)
DFI_10245SWIM-type domain-containing protein. (447 aa)
DFI_10505DNA helicase. (709 aa)
DFI_10955Uncharacterized protein. (375 aa)
mscLLarge-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (128 aa)
DFI_11145Serine/threonine protein kinase. (577 aa)
DFI_11445Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family. (140 aa)
DFI_11570Phenylacetate-CoA oxygenase subunit PaaJ. (168 aa)
DFI_11635Uncharacterized protein. (209 aa)
DFI_11775Cytochrome c-type biogenesis protein; Possible subunit of a heme lyase. (172 aa)
DFI_11780Cytochrome C biogenesis protein. (172 aa)
DFI_11785Cytochrome C biogenesis protein CcmF. (670 aa)
DFI_11870Preprotein translocase YidC. (531 aa)
DFI_12070DUF2726 domain-containing protein. (164 aa)
DFI_12105K+/H+ antiporter. (489 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (157 aa)
Your Current Organism:
Deinococcus ficus
NCBI taxonomy Id: 317577
Other names: CCUG 51391, CIP 108832, D. ficus, DSM 17424 [[Deinococcus mumbaiensis Shashidhar and Bandekar 2006]], DSM 19119, Deinococcus ficus Lai et al. 2006 emend. Kampfer 2009, Deinococcus mumbaiensis, Deinococcus mumbaiensis Shashidhar and Bandekar 2006, Deinococcus sp. 2009, Deinococcus sp. CC-FR2-10, Deinococcus sp. UK, MTCC 7297 [[Deinococcus mumbaiensis Shashidhar and Bandekar 2006]], strain CC-FR2-10, strain CON-1 [[Deinococcus mumbaiensis Shashidhar and Bandekar 2006]]
Server load: low (16%) [HD]