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| | DFI_05660 | Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (265 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (362 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (321 aa) |
| | DFI_05370 | Isocitrate lyase. (443 aa) |
| | DFI_05165 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (297 aa) |
| | DFI_04820 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa) |
| | DFI_04730 | Lactoylglutathione lyase. (126 aa) |
| | DFI_04640 | O-acetylhomoserine aminocarboxypropyltransferase. (456 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (380 aa) |
| | DFI_04065 | Bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase. (361 aa) |
| | panD | Aspartate 1-decarboxylase alpha chain; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa) |
| | moaA | GTP 3',8-cyclase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (334 aa) |
| | DFI_03490 | Aamy domain-containing protein. (517 aa) |
| | DFI_03425 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (268 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa) |
| | dacA | Diadenylate cyclase; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (299 aa) |
| | mltG | Endolytic murein transglycosylase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (343 aa) |
| | speA | Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (639 aa) |
| | DFI_02320 | Aspartate ammonia-lyase. (478 aa) |
| | DFI_02275 | Fructose-1,6-bisphosphate aldolase, class II. (305 aa) |
| | cobD | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (288 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (242 aa) |
| | moaC | Cyclic pyranopterin monophosphate synthase; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (177 aa) |
| | DFI_01640 | Uncharacterized protein. (139 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (161 aa) |
| | purK | N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (374 aa) |
| | DFI_01035 | Menaquinone biosynthesis decarboxylase; Belongs to the UbiD family. (612 aa) |
| | DFI_00925 | 7,8-dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa) |
| | menC | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (370 aa) |
| | DFI_00850 | Cobalamin biosynthesis protein CbiX. (469 aa) |
| | DFI_00345 | Lycopene cyclase. (501 aa) |
| | DFI_00165 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase. (198 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (423 aa) |
| | argH | Argininosuccinate lyase. (468 aa) |
| | DFI_13110 | Methionine gamma-lyase. (396 aa) |
| | mqnA | Chorismate dehydratase; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (276 aa) |
| | DFI_12810 | Carbonic anhydrase. (246 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (153 aa) |
| | psuG | Pseudouridine-5'-phosphate glycosidase; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (310 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (610 aa) |
| | DFI_12260 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (396 aa) |
| | DFI_12230 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (346 aa) |
| | luxS | S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (155 aa) |
| | DFI_11270 | Cysteine synthase. (416 aa) |
| | mqnD | 1,4-dihydroxy-6-naphtoate synthase; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (288 aa) |
| | tnaA | Tryptophanase; Belongs to the beta-eliminating lyase family. (468 aa) |
| | tpl | Tyrosine phenol-lyase. (471 aa) |
| | ribBA | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (394 aa) |
| | DFI_10225 | Glutaconyl-CoA decarboxylase subunit beta. (374 aa) |
| | DFI_10215 | Oxaloacetate decarboxylase gamma chain; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the OadG family. (131 aa) |
| | DFI_10205 | Uncharacterized protein. (743 aa) |
| | DFI_10135 | 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase. (259 aa) |
| | ilvA | L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (519 aa) |
| | DFI_10115 | CoA ester lyase; Belongs to the HpcH/HpaI aldolase family. (268 aa) |
| | DFI_10025 | Carotenoid 1,2-hydratase. (324 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (352 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (382 aa) |
| | DFI_09775 | Uncharacterized protein. (228 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | DFI_09520 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (221 aa) |
| | DFI_09485 | Carboxynorspermidine decarboxylase. (430 aa) |
| | DFI_09240 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (443 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (836 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (475 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (266 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (529 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (559 aa) |
| | hutH | Histidine ammonia-lyase. (500 aa) |
| | DFI_08920 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (296 aa) |
| | DFI_08850 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (333 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (428 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (162 aa) |
| | DFI_08675 | Uncharacterized protein. (271 aa) |
| | DFI_08490 | 4a-hydroxytetrahydrobiopterin dehydratase. (96 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (196 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa) |
| | DFI_07770 | Oxaloacetate decarboxylase. (502 aa) |
| | DFI_07750 | Bifunctional chorismate mutase/prephenate dehydratase. (295 aa) |
| | nnrD | ADP-dependent (S)-NAD(P)H-hydrate dehydratase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family. (505 aa) |
| | fabZ | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (145 aa) |
| | GCA_000419625_02424 | annotation not available (84 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (576 aa) |
| | DFI_07345 | CoA ester lyase; Belongs to the HpcH/HpaI aldolase family. (292 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa) |
| | DFI_07070 | Homoaconitate hydratase; Belongs to the LeuD family. (167 aa) |
| | pdxT | Pyridoxal 5'-phosphate synthase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa) |
| | pdxS | Pyridoxal 5'-phosphate synthase subunit PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (295 aa) |
| | tal | Probable transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (275 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (416 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (220 aa) |
| | DFI_06045 | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (265 aa) |
| | mutM | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (275 aa) |
| | DFI_05940 | Antibiotic resistance protein VanZ. (120 aa) |
| | menC-2 | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (376 aa) |
| | DFI_13780 | GNAT family N-acetyltransferase. (267 aa) |
| | DFI_13725 | Uncharacterized protein. (278 aa) |
| | DFI_16150 | Uncharacterized protein. (292 aa) |
| | DFI_16085 | Diaminopropionate ammonia-lyase. (385 aa) |
| | DFI_16030 | Dihydrodipicolinate synthase family protein; Belongs to the DapA family. (307 aa) |
| | DFI_15600 | Uncharacterized protein. (435 aa) |
| | DFI_15310 | Argininosuccinate lyase. (484 aa) |
| | DFI_15105 | BTAD domain-containing protein. (678 aa) |
| | menC-3 | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (405 aa) |
| | murQ | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (314 aa) |
| | DFI_17950 | Uncharacterized protein. (268 aa) |
| | DFI_17085 | Cobalamin biosynthesis protein CbiX. (472 aa) |
| | DFI_17090 | Uroporphyrinogen-III C-methyltransferase. (511 aa) |
| | GCA_000419625_03556 | annotation not available (341 aa) |
| | DFI_17440 | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Belongs to the HpcH/HpaI aldolase family. (270 aa) |
| | DFI_17445 | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase. (277 aa) |
| | DFI_17480 | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase. (266 aa) |
| | GCA_000419625_03695 | annotation not available (213 aa) |
| | GCA_000419625_03872 | annotation not available (645 aa) |
