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hisD hisD DFI_01415 DFI_01415 hisA hisA hisC hisC hisG hisG hisZ hisZ hisF hisF hisI hisI hutU hutU hutI hutI hutH hutH hisB hisB hisH hisH DFI_06405 DFI_06405 DFI_05885 DFI_05885 DFI_17735 DFI_17735
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa)
DFI_01415Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (488 aa)
hisA1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (242 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (360 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (212 aa)
hisZATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (370 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa)
hisIHistidine biosynthesis bifunctional protein HisIE; In the N-terminal section; belongs to the PRA-CH family. (221 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (559 aa)
hutIImidazolonepropionase. (399 aa)
hutHHistidine ammonia-lyase. (500 aa)
hisBImidazoleglycerol-phosphate dehydratase. (196 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa)
DFI_06405Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (261 aa)
DFI_05885Flavin monoamine oxidase. (532 aa)
DFI_17735Uncharacterized protein. (360 aa)
Your Current Organism:
Deinococcus ficus
NCBI taxonomy Id: 317577
Other names: CCUG 51391, CIP 108832, D. ficus, DSM 17424 [[Deinococcus mumbaiensis Shashidhar and Bandekar 2006]], DSM 19119, Deinococcus ficus Lai et al. 2006 emend. Kampfer 2009, Deinococcus mumbaiensis, Deinococcus mumbaiensis Shashidhar and Bandekar 2006, Deinococcus sp. 2009, Deinococcus sp. CC-FR2-10, Deinococcus sp. UK, MTCC 7297 [[Deinococcus mumbaiensis Shashidhar and Bandekar 2006]], strain CC-FR2-10, strain CON-1 [[Deinococcus mumbaiensis Shashidhar and Bandekar 2006]]
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