| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Dgeo_1114 | gcvH | Dgeo_1114 | Dgeo_1906 | Serine--pyruvate transaminase; PFAM: aminotransferase, class V: (2.4e-14); KEGG: dra:DR1350 putative aminotransferase, ev=1e-170, 78% identity. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.910 |
| Dgeo_1114 | gcvP | Dgeo_1114 | Dgeo_1907 | Serine--pyruvate transaminase; PFAM: aminotransferase, class V: (2.4e-14); KEGG: dra:DR1350 putative aminotransferase, ev=1e-170, 78% identity. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.934 |
| Dgeo_1114 | gcvT | Dgeo_1114 | Dgeo_1905 | Serine--pyruvate transaminase; PFAM: aminotransferase, class V: (2.4e-14); KEGG: dra:DR1350 putative aminotransferase, ev=1e-170, 78% identity. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.928 |
| Dgeo_1114 | glyA | Dgeo_1114 | Dgeo_0221 | Serine--pyruvate transaminase; PFAM: aminotransferase, class V: (2.4e-14); KEGG: dra:DR1350 putative aminotransferase, ev=1e-170, 78% identity. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.921 |
| gcvH | Dgeo_1114 | Dgeo_1906 | Dgeo_1114 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine--pyruvate transaminase; PFAM: aminotransferase, class V: (2.4e-14); KEGG: dra:DR1350 putative aminotransferase, ev=1e-170, 78% identity. | 0.910 |
| gcvH | gcvP | Dgeo_1906 | Dgeo_1907 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| gcvH | gcvT | Dgeo_1906 | Dgeo_1905 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
| gcvH | glyA | Dgeo_1906 | Dgeo_0221 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.973 |
| gcvP | Dgeo_1114 | Dgeo_1907 | Dgeo_1114 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Serine--pyruvate transaminase; PFAM: aminotransferase, class V: (2.4e-14); KEGG: dra:DR1350 putative aminotransferase, ev=1e-170, 78% identity. | 0.934 |
| gcvP | gcvH | Dgeo_1907 | Dgeo_1906 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| gcvP | gcvT | Dgeo_1907 | Dgeo_1905 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
| gcvP | glyA | Dgeo_1907 | Dgeo_0221 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.999 |
| gcvT | Dgeo_1114 | Dgeo_1905 | Dgeo_1114 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Serine--pyruvate transaminase; PFAM: aminotransferase, class V: (2.4e-14); KEGG: dra:DR1350 putative aminotransferase, ev=1e-170, 78% identity. | 0.928 |
| gcvT | gcvH | Dgeo_1905 | Dgeo_1906 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| gcvT | gcvP | Dgeo_1905 | Dgeo_1907 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| gcvT | glyA | Dgeo_1905 | Dgeo_0221 | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
| glyA | Dgeo_1114 | Dgeo_0221 | Dgeo_1114 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine--pyruvate transaminase; PFAM: aminotransferase, class V: (2.4e-14); KEGG: dra:DR1350 putative aminotransferase, ev=1e-170, 78% identity. | 0.921 |
| glyA | gcvH | Dgeo_0221 | Dgeo_1906 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.973 |
| glyA | gcvP | Dgeo_0221 | Dgeo_1907 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| glyA | gcvT | Dgeo_0221 | Dgeo_1905 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.996 |