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Dgeo_0009 Dgeo_0009 Dgeo_0050 Dgeo_0050 menG menG prmC prmC Dgeo_0072 Dgeo_0072 glyA glyA Dgeo_0285 Dgeo_0285 panB panB Dgeo_0463 Dgeo_0463 trmFO trmFO pyrB pyrB purH purH Dgeo_0522 Dgeo_0522 Dgeo_0619 Dgeo_0619 rlmN rlmN rsmH rsmH Dgeo_0838 Dgeo_0838 prmA prmA Dgeo_0924 Dgeo_0924 Dgeo_0926 Dgeo_0926 Dgeo_0927 Dgeo_0927 Dgeo_0969 Dgeo_0969 Dgeo_1083 Dgeo_1083 rsmA rsmA Dgeo_1186 Dgeo_1186 Dgeo_1336 Dgeo_1336 Dgeo_1462 Dgeo_1462 trmD trmD purU purU Dgeo_1498 Dgeo_1498 Dgeo_1545 Dgeo_1545 Dgeo_1546 Dgeo_1546 Dgeo_1582 Dgeo_1582 argF argF Dgeo_1612 Dgeo_1612 Dgeo_1622 Dgeo_1622 rsmI rsmI rlmH rlmH Dgeo_1777 Dgeo_1777 gcvT gcvT trmJ trmJ Dgeo_2017 Dgeo_2017 Dgeo_2022 Dgeo_2022 thyX thyX Dgeo_2042 Dgeo_2042 Dgeo_2089 Dgeo_2089 trmB trmB Dgeo_2129 Dgeo_2129 Dgeo_2131 Dgeo_2131 accA accA accD accD trmH trmH fmt fmt rsmG rsmG
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Dgeo_0009SAM-dependent methyltransferase DUF633; PFAM: protein of unknown function DUF633: (7e-65); KEGG: dra:DR0276 hypothetical protein, ev=2e-82, 69% identity. (225 aa)
Dgeo_0050PFAM: Cyclopropane-fatty-acyl-phospholipid synthase: (8.8e-122) Methyltransferase type 11: (6.2e-16) Methyltransferase type 12: (1.3e-16); KEGG: dra:DR2187 cyclopropane-fatty-acyl-phospholipid synthase, putative, ev=1e-170, 66% identity. (471 aa)
menGUbiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (239 aa)
prmCModification methylase, HemK family; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (283 aa)
Dgeo_0072tRNA/rRNA methyltransferase (SpoU); Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (153 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
Dgeo_0285SAM-dependent methyltransferase, rRNA adenine N-6-methyltransferase family; PFAM: conserved hypothetical protein 95: (8.4e-56) methyltransferase small: (0.00034); KEGG: dra:DR0643 N-6 adenine-specific DNA restriction methylase, putative, ev=9e-61, 63% identity. (191 aa)
panBKetopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa)
Dgeo_0463Methyltransferase type 11; PFAM: Methionine biosynthesis MetW: (0.00046) Methyltransferase type 11: (9.5e-28) Methyltransferase type 12: (2.2e-15); KEGG: dra:DR0356 methyltransferase, putative, BioC family, ev=8e-39, 55% identity. (197 aa)
trmFOtRNA uridine 5-carboxymethylaminomethyl modification enzyme; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. (458 aa)
pyrBKEGG: dra:DR1109 aspartate carbamoyltransferase catalytic chain, ev=1e-149, 86% identity; TIGRFAM: aspartate carbamoyltransferase: (2.7e-112); PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region: (9.4e-27) aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain: (3.6e-50); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: dra:DR0868 phosphoribosylaminoimidazolecarboxamide formyltransferase. (514 aa)
Dgeo_05222-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1;4- benzoquinol methylase; PFAM: Methyltransferase type 11: (1.1e-21) Methyltransferase type 12: (9.1e-10); KEGG: dra:DR2562 3-demethylubiquinone-9 3-methyltransferase, putative, ev=4e-66, 64% identity. (234 aa)
Dgeo_0619SAM-dependent methyltransferase; KEGG: dra:DR0049 hypothetical protein, ev=1e-164, 73% identity. (403 aa)
rlmN23S rRNA m(2)A-2503 methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (344 aa)
rsmHMethyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (308 aa)
Dgeo_0838Protein of unknown function DUF558; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (230 aa)
prmA[LSU ribosomal protein L11P]-lysine N-methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (279 aa)
Dgeo_0924Adenine-specific DNA methylase; KEGG: cte:CT1160 type III restriction system endonuclease, putative, ev=1e-20, 39% identity. (139 aa)
Dgeo_0926Adenine-specific DNA methylase; PFAM: Eco57I restriction endonuclease: (1.3e-53); KEGG: cte:CT1160 type III restriction system endonuclease, putative, ev=1e-138, 75% identity. (321 aa)
Dgeo_0927KEGG: cte:CT1159 type III restriction system methylase, ev=8e-94, 77% identity. (213 aa)
Dgeo_0969SAM-dependent methyltransferase; KEGG: dra:DR1694 hypothetical protein, ev=1e-176, 79% identity. (395 aa)
Dgeo_1083PFAM: tRNA/rRNA methyltransferase (SpoU): (2.1e-45); KEGG: dra:DR1017 rRNA methylase, ev=4e-98, 71% identity. (263 aa)
rsmADimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (281 aa)
Dgeo_1186PFAM: Methyltransferase type 11: (6.2e-23) Methyltransferase type 12: (1e-22); KEGG: dra:DR1078 antibiotic biosynthesis protein LmbJ, putative, ev=1e-105, 67% identity. (262 aa)
Dgeo_13365-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1226 aa)
Dgeo_1462SAM dependent methyltransferase; KEGG: dra:DR1834 hypothetical protein, ev=1e-122, 68% identity. (318 aa)
trmDtRNA (Guanine37-N(1)-) methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (265 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (296 aa)
Dgeo_1498rRNA methyltransferase, sun family protein; PFAM: Fmu (Sun): (9e-14) NusB/RsmB/TIM44: (4.9e-28); KEGG: dra:DR2168 sun protein, putative, ev=1e-161, 72% identity; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (427 aa)
Dgeo_1545KEGG: tfu:Tfu_0724 putative type II DNA modification enzyme, ev=0.0, 43% identity. (1318 aa)
Dgeo_1546PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. (190 aa)
Dgeo_1582PFAM: putative RNA methylase: (9e-65) Methyltransferase type 11: (9.6e-07); KEGG: dra:DR1669 hypothetical protein, ev=1e-152, 72% identity. (357 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (307 aa)
Dgeo_1612PFAM: Isoprenylcysteine carboxyl methyltransferase: (4.8e-41); KEGG: dra:DR1745 hypothetical protein, ev=3e-69, 71% identity. (225 aa)
Dgeo_162216S rRNA m(2)G 1207 methyltransferase; PFAM: conserved hypothetical protein 95: (3.7e-05) methyltransferase small: (1.1e-63) Methyltransferase type 11: (1.3e-07) Methyltransferase type 12: (3.9e-10); KEGG: dra:DR0914 hypothetical protein, ev=1e-130, 78% identity; Belongs to the methyltransferase superfamily. (407 aa)
rsmITetrapyrrole methylase family enzyme; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (280 aa)
rlmH23S rRNA (pseudouridine-1915-N(3)-) methyltransferase; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (148 aa)
Dgeo_1777PFAM: (Uracil-5)-methyltransferase: (0.00015); KEGG: dra:DR0238 hypothetical protein, ev=1e-92, 73% identity; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (410 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (374 aa)
trmJRNA methyltransferase TrmH, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (254 aa)
Dgeo_2017PFAM: N-6 DNA methylase: (2.7e-181); KEGG: bte:BTH_I2743 type I restriction system adenine methylase, ev=0.0, 88% identity. (517 aa)
Dgeo_2022TIGRFAM: RNA methyltransferase TrmH, group 3: (9.7e-63); PFAM: tRNA/rRNA methyltransferase (SpoU): (1e-58) RNA 2-O ribose methyltransferase, substrate binding: (6.5e-18); KEGG: dra:DR0748 RNA methyltransferase, TrmH family, ev=1e-104, 80% identity; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (246 aa)
thyXThymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (233 aa)
Dgeo_2042PFAM: Methyltransferase type 11: (2.5e-17) Methyltransferase type 12: (4.3e-16); KEGG: dra:DR2622 hypothetical protein, ev=1e-105, 72% identity. (256 aa)
Dgeo_2089PFAM: Methyltransferase type 11: (0.0012) Methyltransferase type 12: (1.1e-10); KEGG: dra:DR1676 hypothetical protein, ev=1e-129, 76% identity. (315 aa)
trmBtRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (331 aa)
Dgeo_2129Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase, N-terminal domain: (1.4e-19); KEGG: cvi:CV0813 uroporphyrin-III C-methyltransferase, ev=2e-23, 46% identity. (188 aa)
Dgeo_2131TIGRFAM: uroporphyrin-III C-methyltransferase: (9e-132); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase: (6.1e-80) Uroporphyrinogen III synthase HEM4: (1e-26); KEGG: dra:DRA0011 uroporphyrin-III synthase / uroporphyrin-III C-methyltransferase, ev=1e-147, 60% identity. (507 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (306 aa)
accDacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (284 aa)
trmHtRNA (guanosine-2'-O-)-methyltransferase; Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (216 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (319 aa)
rsmG16S rRNA m(7)G-527 methyltransferase; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (245 aa)
Your Current Organism:
Deinococcus geothermalis
NCBI taxonomy Id: 319795
Other names: D. geothermalis DSM 11300, Deinococcus geothermalis AG-3a, Deinococcus geothermalis CIP 105573, Deinococcus geothermalis DSM 11300, Deinococcus geothermalis str. DSM 11300, Deinococcus geothermalis strain DSM 11300
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