Your Input: | |
| | Dgeo_0847 | PFAM: phosphoribosyltransferase: (2e-05); KEGG: dra:DR0568 adenine phosphoribosyltransferase, ev=2e-75, 81% identity. (286 aa) |
| | Dgeo_0882 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase: (2.8e-187); KEGG: dra:DR2160 delta-aminolevulinic acid dehydratase, ev=1e-137, 75% identity; Belongs to the ALAD family. (327 aa) |
| | Dgeo_0902 | PFAM: transcription elongation factor GreA/GreB region: (2.7e-08); KEGG: dra:DR1970 transcription elongation factor, ev=2e-64, 79% identity; Belongs to the GreA/GreB family. (162 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (437 aa) |
| | queA | S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (366 aa) |
| | Dgeo_0947 | PFAM: bifunctional deaminase-reductase-like: (7.2e-33); KEGG: bce:BC3158 pyrimidine reductase, ev=5e-56, 56% identity. (180 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (474 aa) |
| | Dgeo_0985 | TIGRFAM: glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase: (2.8e-86); PFAM: glutamine amidotransferase class-I: (4.1e-79); KEGG: dra:DR1766 anthranilate synthase component II, ev=2e-86, 77% identity. (213 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (351 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (440 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (414 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa) |
| | Dgeo_1040 | Prephenate dehydrogenase; PFAM: amino acid-binding ACT: (9.4e-08) Prephenate dehydrogenase: (4.2e-81); KEGG: dra:DR1122 prephenate dehydrogenase, ev=1e-166, 83% identity. (370 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (257 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (425 aa) |
| | pdxS | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (303 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (201 aa) |
| | Dgeo_1162 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (512 aa) |
| | Dgeo_1163 | KEGG: tth:TTC0621 nicotinate-nucleotide pyrophosphorylase [carboxylating], ev=1e-72, 58% identity; TIGRFAM: nicotinate-nucleotide pyrophosphorylase: (2.2e-120); PFAM: Quinolinate phosphoribosyl transferase: (7.7e-72); Belongs to the NadC/ModD family. (278 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (331 aa) |
| | Dgeo_1192 | Hydroxymethylbutenyl pyrophosphate reductase lytB related protein. (262 aa) |
| | nusA | NusA antitermination factor; Participates in both transcription termination and antitermination. (395 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (360 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (207 aa) |
| | comB | PFAM: 2-phosphosulfolactate phosphatase: (1.9e-79); KEGG: dra:DR1400 putative 2-phosphosulfolactate phosphatase, ev=6e-81, 67% identity; Belongs to the ComB family. (241 aa) |
| | Dgeo_1325 | Nicotinate phosphoribosyltransferase related protein; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (486 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (288 aa) |
| | Dgeo_1334 | PFAM: prephenate dehydratase: (1.5e-50) amino acid-binding ACT: (0.00036); KEGG: dra:DR1147 prephenate dehydratase, ev=1e-121, 76% identity. (303 aa) |
| | Dgeo_1346 | RNA polymerase, sigma 28 subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (403 aa) |
| | purD | KEGG: dra:DR1431 phosphoribosylamine--glycine ligase, ev=1e-174, 74% identity; TIGRFAM: phosphoribosylamine--glycine ligase: (5.4e-166); PFAM: phosphoribosylglycinamide synthetase: (1e-95); Belongs to the GARS family. (417 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (427 aa) |
| | pyrF | TIGRFAM: Orotidine 5'-phosphate decarboxylase subfamily 2: (7.9e-123); PFAM: Orotidine 5'-phosphate decarboxylase: (3.3e-39); KEGG: dra:DR2200 orotidine-5'-phosphate decarboxylase, ev=1e-118, 81% identity; Belongs to the OMP decarboxylase family. Type 2 subfamily. (273 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (296 aa) |
| | Dgeo_1519 | RNA polymerase, sigma-24 subunit, RpoE; PFAM: sigma-70 region 2: (4.1e-17) sigma-70 region 4: (9.5e-16) Sigma-70, region 4 type 2: (6.2e-19); KEGG: dra:DR0180 RNA polymerase sigma-E factor, ev=1e-81, 80% identity; Belongs to the sigma-70 factor family. ECF subfamily. (191 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (393 aa) |
| | Dgeo_1536 | PFAM: transcriptional coactivator/pterin dehydratase: (1.2e-11); KEGG: nph:NP1766A homolog to 4A-hydroxytetrahydrobiopterin dehydratase, ev=1e-11, 37% identity. (118 aa) |
| | Dgeo_1546 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. (190 aa) |
| | Dgeo_1550 | PFAM: phosphoribosyltransferase: (2e-10); KEGG: dra:DR0878 adenine phosphoribosyltransferase, putative, ev=1e-72, 77% identity. (176 aa) |
| | Dgeo_1572 | Chorismate mutase / 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase: (9.8e-193) Chorismate mutase, G-positive and Deinococcus: (3.8e-67); PFAM: Chorismate mutase: (8.8e-28) DAHP synthetase I/KDSA: (3.6e-129); KEGG: dra:DR1001 phospho-2-dehydro-3-deoxyheptonate aldolase / chorismate mutase, ev=1e-173, 85% identity. (379 aa) |
| | Dgeo_1587 | PFAM: Indole-3-glycerol phosphate synthase: (3e-77); KEGG: dra:DR1426 indole-3-glycerol phosphate synthase, ev=1e-91, 71% identity; Belongs to the TrpC family. (262 aa) |
| | Dgeo_1588 | KEGG: dra:DR1376 hypoxanthine-guanine phosphoribosyltransferase, ev=5e-81, 84% identity; TIGRFAM: hypoxanthine phosphoribosyltransferase: (4.1e-101); PFAM: phosphoribosyltransferase: (8.8e-32); Belongs to the purine/pyrimidine phosphoribosyltransferase family. (175 aa) |
| | Dgeo_1609 | PFAM: PHP-like: (6.9e-37); SMART: DNA polymerase X: (3.2e-07) Phosphoesterase PHP-like: (6.5e-09); KEGG: dra:DR0467 hypothetical DNA polymerase / putative histidinol phosphatase, ev=0.0, 64% identity. (572 aa) |
| | purM | KEGG: dra:DR1394 phosphoribosylformylglycinamidine cyclo-ligase, ev=1e-158, 80% identity; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase: (1.4e-103); PFAM: AIR synthase related protein: (8.1e-43) AIR synthase related protein-like: (6.9e-35). (355 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (907 aa) |
| | Dgeo_1678 | P-loop ATPase; KEGG: dra:DR1870 hypothetical protein, ev=9e-89, 68% identity. (256 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (149 aa) |
| | Dgeo_1710 | PFAM: Chlorite dismutase: (6.9e-82); KEGG: dra:DR1481 hypothetical protein, ev=1e-121, 84% identity. (248 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (382 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (180 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (368 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (161 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (266 aa) |
| | Dgeo_1750 | PFAM: AMP-dependent synthetase and ligase: (5.5e-117); KEGG: dra:DR0460 acetyl-CoA synthase, ev=0.0, 78% identity. (636 aa) |
| | acsA | Acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (655 aa) |
| | Dgeo_1775 | PFAM: ribonucleotide reductase: (3.6e-32); KEGG: dra:DRB0109 ribonucleoside-diphosphate reductase beta chain, ev=1e-98, 56% identity. (319 aa) |
| | Dgeo_1809 | TIGRFAM: riboflavin biosynthesis protein RibF: (7.1e-81); PFAM: Riboflavin kinase / FAD synthetase: (9.8e-47); KEGG: dra:DR1008 riboflavin kinase / FMN adenylyltransferase, ev=1e-136, 79% identity; Belongs to the ribF family. (303 aa) |
| | Dgeo_1818 | KEGG: dra:DR0856 DNA polymerase III, epsilon subunit, putative, ev=4e-63, 68% identity; TIGRFAM: DNA polymerase III, epsilon subunit: (5e-07); PFAM: Exonuclease, RNase T and DNA polymerase III: (1.8e-39); SMART: Exonuclease: (7.9e-47). (180 aa) |
| | Dgeo_1821 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa) |
| | rpoA | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (331 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (197 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (186 aa) |
| | Dgeo_1886 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (594 aa) |
| | Dgeo_1889 | KEGG: dra:DR0494 DNA topology modulation protein FlaR-related protein, ev=2e-53, 61% identity. (163 aa) |
| | Dgeo_1903 | PFAM: 5-formyltetrahydrofolate cyclo-ligase: (5.4e-38); KEGG: dra:DR1815 hypothetical protein, ev=6e-57, 65% identity. (184 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (587 aa) |
| | Dgeo_1919 | KEGG: dra:DRA0171 phosphomethylpyrimidine kinase, ev=7e-88, 71% identity; TIGRFAM: Phosphomethylpyrimidine kinase type-2: (1.9e-103); PFAM: Phosphomethylpyrimidine kinase type-1: (4.6e-120). (254 aa) |
| | thiG | Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (267 aa) |
| | Dgeo_1922 | TIGRFAM: thiamine biosynthesis protein ThiS: (6.9e-21); PFAM: thiamineS: (2.5e-11); KEGG: dra:DRA0173 thiamin biosynthesis ThiS, ev=2e-20, 71% identity. (62 aa) |
| | thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (221 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (609 aa) |
| | Dgeo_1939 | TIGRFAM: thiamine pyrophosphokinase: (2.2e-45); PFAM: Thiamin pyrophosphokinase, catalytic region: (4.4e-27); KEGG: dra:DR0552 hypothetical protein, ev=4e-79, 74% identity. (212 aa) |
| | hemL | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase: (4.9e-217); PFAM: aminotransferase class-III: (3.9e-73); KEGG: dra:DR0555 glutamate-1-semialdehyde 2,1-aminomutase, ev=0.0, 74% identity. (457 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (481 aa) |
| | Dgeo_1978 | Domain of unknown function DUF1730; PFAM: HEAT: (0.0045) 4Fe-4S ferredoxin, iron-sulfur binding: (0.00021) Domain of unknown function DUF1730: (6.9e-12); SMART: PBS lyase HEAT-like repeat: (3.8e-06); KEGG: tth:TTC0112 iron-sulfur cluster-binding protein, ev=5e-88, 51% identity. (397 aa) |
| | Dgeo_1979 | Epoxide Hydrolase; KEGG: dra:DR1803 hypothetical protein, ev=1e-36, 60% identity. (126 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | Dgeo_1984 | Glycosyl hydrolase family 98. (417 aa) |
| | Dgeo_1993 | ApaG-like protein; PFAM: ApaG: (5.6e-56); KEGG: dra:DR0228 ApaG protein, ev=9e-39, 58% identity. (130 aa) |
| | Dgeo_2008 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (723 aa) |
| | thyX | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (233 aa) |
| | Dgeo_2037 | DnaB-like protein helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (849 aa) |
| | atpD | V-type H+-ATPase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (222 aa) |
| | atpB | V-type H+-ATPase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. (470 aa) |
| | atpA | V-type H+-ATPase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (582 aa) |
| | atpC | V-type H+-ATPase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (325 aa) |
| | atpE | V-type H+-ATPase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (185 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit: (6.3e-239); PFAM: glutamine amidotransferase class-I: (1.9e-65) Carbamoyl-phosphate synthase, small chain: (1.3e-72); KEGG: dra:DR0684 carbamoyl-phosphate synthase small chain, ev=0.0, 95% identity; Belongs to the CarA family. (394 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit: (0); PFAM: phosphoribosylglycinamide synthetase: (0.0013) protein of unknown function DUF201: (0.0017) Carbamoyl-phosphate synthase L chain, ATP-binding: (5.1e-23) Carbamoyl-phosphate synthetase large chain, oligomerisation: (2.8e-60) Carbamoyl-phosphate synthetase large chain-like: (1.3e-29); KEGG: dra:DR0668 carbamoyl-phosphate synthase large chain, ev=0.0, 89% identity. (1029 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (365 aa) |
| | Dgeo_2129 | Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase, N-terminal domain: (1.4e-19); KEGG: cvi:CV0813 uroporphyrin-III C-methyltransferase, ev=2e-23, 46% identity. (188 aa) |
| | Dgeo_2131 | TIGRFAM: uroporphyrin-III C-methyltransferase: (9e-132); PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase: (6.1e-80) Uroporphyrinogen III synthase HEM4: (1e-26); KEGG: dra:DRA0011 uroporphyrin-III synthase / uroporphyrin-III C-methyltransferase, ev=1e-147, 60% identity. (507 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (737 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (306 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (284 aa) |
| | Dgeo_2213 | Nucleotide-diphospho-sugar transferase superfamily protein; KEGG: dra:DR2329 hypothetical protein, ev=8e-93, 69% identity. (264 aa) |
| | cmk | KEGG: dra:DR2543 cytidylate kinase, ev=1e-79, 76% identity; TIGRFAM: cytidylate kinase: (8.9e-44); PFAM: cytidylate kinase region: (1.6e-31). (209 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI): (6.9e-40); KEGG: dra:DR0123 phosphoribosylanthranilate isomerase, ev=1e-67, 66% identity; Belongs to the TrpF family. (214 aa) |
| | Dgeo_2269 | RNA polymerase, sigma-24 subunit, RpoE; PFAM: sigma-70 region 2: (2.2e-20) sigma-70 region 4: (1.1e-16) Sigma-70, region 4 type 2: (7.5e-19); KEGG: sco:SCO3892 putative RNA polymerase sigma factor, ev=3e-23, 43% identity; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa) |
| | Dgeo_2274 | KEGG: bba:Bd2777 predicted hydrolase of HD superfamily, ev=5e-23, 41% identity. (193 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (242 aa) |
| | Dgeo_2315 | Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (392 aa) |
| | Dgeo_2324 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (403 aa) |
| | Dgeo_0003 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (360 aa) |
| | pta | Phosphate acetyltransferase; Involved in acetate metabolism; In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. (703 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (472 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (746 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (222 aa) |
| | purS | Phosphoribosylformylglycinamidine synthetase PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...] (85 aa) |
| | purC | KEGG: dra:DR0226 phosphoribosylaminoimidazole-succinocarboxamide synthase, ev=1e-108, 82% identity; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase: (1.5e-104); PFAM: SAICAR synthetase: (8.2e-90). (241 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (371 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (177 aa) |
| | Dgeo_0083 | KEGG: dra:DR0340 folylpolyglutamate synthase / dihydrofolate synthase, ev=1e-157, 73% identity; TIGRFAM: FolC bifunctional protein: (1.5e-116); PFAM: cytoplasmic peptidoglycan synthetases-like: (2.6e-06) Mur ligase, middle region: (8.4e-05). (404 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa) |
| | Dgeo_0101 | PFAM: deoxynucleoside kinase: (1.2e-39); KEGG: dra:DR0298 deoxyguanosine kinase/deoxyadenosine kinase subunit, ev=2e-99, 83% identity. (207 aa) |
| | Dgeo_0102 | PFAM: deoxynucleoside kinase: (8.5e-18); KEGG: dra:DR0299 deoxyguanosine kinase/deoxyadenosine kinase subunit, ev=2e-74, 72% identity. (205 aa) |
| | Dgeo_0133 | Metal dependent phosphohydrolase; KEGG: dra:DR2582 hypothetical protein, ev=9e-71, 74% identity; TIGRFAM: conserved hypothetical protein: (9.5e-30); PFAM: metal-dependent phosphohydrolase, HD subdomain: (1.6e-20); SMART: Metal-dependent phosphohydrolase, HD region: (4.4e-14). (204 aa) |
| | dacA | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (278 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (199 aa) |
| | pdxY | Pyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (299 aa) |
| | Dgeo_0198 | GTPase, G3E family; PFAM: cobalamin synthesis protein, P47K: (7.5e-65) cobalamin synthesis CobW-like: (1.8e-29); KEGG: dra:DR2408 CobW protein, putative, ev=1e-140, 80% identity. (322 aa) |
| | udk | TIGRFAM: uridine kinase: (8.6e-102); PFAM: phosphoribulokinase/uridine kinase: (5.1e-47); KEGG: dra:DR0159 uridine kinase, ev=3e-98, 90% identity. (204 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (404 aa) |
| | folE | PFAM: GTP cyclohydrolase I: (1.7e-55); KEGG: dra:DR0036 GTP cyclohydrolase I, ev=2e-82, 80% identity. (202 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (99 aa) |
| | Dgeo_0255 | KEGG: dra:DR0507 DNA polymerase III alpha subunit, ev=0.0, 85% identity; TIGRFAM: DNA polymerase III, alpha subunit: (0); PFAM: PHP-like: (3e-72) nucleic acid binding, OB-fold, tRNA/helicase-type: (8.5e-09); SMART: Phosphoesterase PHP-like: (5.5e-27). (1322 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (841 aa) |
| | Dgeo_0274 | PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein: (3.5e-12); KEGG: dra:DR2241 hypothetical protein, ev=1e-137, 54% identity. (479 aa) |
| | coaD | Phosphopantetheine adenylyltransferase, CoaD; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (184 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (388 aa) |
| | Dgeo_0333 | TIGRFAM: FolC bifunctional protein: (1.6e-122); PFAM: cytoplasmic peptidoglycan synthetases-like: (3.7e-11) Mur ligase, middle region: (1.7e-08); KEGG: dra:DR2575 folyl-polyglutamate synthetase, ev=1e-126, 69% identity; Belongs to the folylpolyglutamate synthase family. (414 aa) |
| | Dgeo_0341 | Mannose-6-phosphate isomerase, type 2; PFAM: Nucleotidyl transferase: (3.2e-70); KEGG: dra:DRA0032 mannose-1-phosphate guanylyltransferase, ev=1e-157, 76% identity. (359 aa) |
| | Dgeo_0352 | PFAM: phosphoglucomutase/phosphomannomutase C terminal: (1.7e-05) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I: (1.2e-44) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II: (2.2e-07) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III: (1.4e-07); KEGG: dra:DRA0047 phosphomannomutase, ev=0.0, 78% identity. (475 aa) |
| | Dgeo_0363 | KEGG: dra:DR0268 putative sulfonate/nitrate/taurine transport system substrate-binding protein, ev=1e-129, 73% identity. (317 aa) |
| | Dgeo_0372 | PFAM: protein of unknown function DUF165: (2.1e-05); KEGG: dra:DR0380 hypothetical protein, ev=3e-67, 78% identity. (181 aa) |
| | Dgeo_0373 | KEGG: dra:DR0381 hypothetical protein, ev=3e-37, 67% identity. (124 aa) |
| | Dgeo_0396 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (302 aa) |
| | Dgeo_0397 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (124 aa) |
| | Dgeo_0398 | KEGG: dra:DR0170 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase, ev=3e-54, 69% identity; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase: (1.8e-50); PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK: (1e-47). (163 aa) |
| | ctaB | Cytochrome c oxidase assembly factor, CtaB; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (312 aa) |
| | Dgeo_0409 | PFAM: cytochrome oxidase assembly: (2e-06); KEGG: dra:DR2617 cytochrome AA3-controlling protein CtaA, putative, ev=1e-133, 75% identity. (326 aa) |
| | Dgeo_0426 | PFAM: protein of unknown function DUF179: (9.1e-54); KEGG: dra:DR0357 putative transcriptional regulator, ev=6e-64, 66% identity; Belongs to the UPF0301 (AlgH) family. (176 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | Dgeo_0452 | KEGG: dra:DR1456 ribose-phosphate pyrophosphokinase, ev=1e-156, 88% identity; TIGRFAM: ribose-phosphate pyrophosphokinase: (1.3e-120); PFAM: phosphoribosyltransferase: (2e-23). (355 aa) |
| | Dgeo_0466 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (445 aa) |
| | sigA | RNA polymerase, sigma 28 subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (532 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (202 aa) |
| | Dgeo_0498 | TIGRFAM: glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase: (5.1e-44); PFAM: glutamine amidotransferase class-I: (1.1e-52) Anthranilate synthase component I and chorismate binding protein: (2.7e-120) Anthranilate synthase component I-like: (1.5e-05); KEGG: dra:DR0196 anthranilate synthase, ev=0.0, 77% identity. (642 aa) |
| | pyrD | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (361 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (417 aa) |
| | pyrB | KEGG: dra:DR1109 aspartate carbamoyltransferase catalytic chain, ev=1e-149, 86% identity; TIGRFAM: aspartate carbamoyltransferase: (2.7e-112); PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region: (9.4e-27) aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain: (3.6e-50); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa) |
| | Dgeo_0510 | KEGG: pca:Pcar_0661 hypothetical protein, ev=2e-77, 53% identity. (301 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: dra:DR0868 phosphoribosylaminoimidazolecarboxamide formyltransferase. (514 aa) |
| | folD1 | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | Dgeo_0536 | GTPase (G3E family); PFAM: cobalamin synthesis protein, P47K: (7.2e-66) cobalamin synthesis CobW-like: (2e-15); KEGG: bha:BH1790 hypothetical protein, ev=6e-69, 40% identity. (352 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (547 aa) |
| | tdk | PFAM: thymidine kinase: (1.5e-63); KEGG: dra:DR1984 thymidine kinase, ev=1e-83, 77% identity. (219 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (505 aa) |
| | Dgeo_0606 | RNA polymerase, sigma-24 subunit, RpoE; PFAM: sigma-70 region 2: (1.8e-16) sigma-70 region 4: (4.3e-14) Sigma-70, region 4 type 2: (4.6e-13); KEGG: ttj:TTHB211 putative RNA polymerase sigma factor, ev=2e-27, 40% identity; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa) |
| | Dgeo_0632 | PFAM: TPR repeat: (0.44) Tetratricopeptide TPR_4: (0.002) Tetratricopeptide TPR_2: (0.0002); SMART: Tetratricopeptide region: (0.029); KEGG: dra:DR0937 tetratricopeptide repeat family protein, ev=1e-151, 54% identity. (541 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1537 aa) |
| | rpoB | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1152 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (190 aa) |
| | Dgeo_0666 | TIGRFAM: ATP: (4.1e-106); PFAM: cobalamin adenosyltransferase: (8.8e-91); KEGG: dra:DR1638 hypothetical protein, ev=1e-78, 77% identity; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa) |
| | greA | Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (156 aa) |
| | Dgeo_0688 | TIGRFAM: adenylosuccinate lyase: (2.6e-179); PFAM: fumarate lyase: (2e-49); KEGG: dra:DR2178 adenylosuccinate lyase, ev=0.0, 86% identity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (169 aa) |
| | folD2 | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (289 aa) |
| | Dgeo_0702 | P-loop ATPase, FlaR-like protein; KEGG: dra:DR0202 hypothetical protein, ev=2e-17, 43% identity. (87 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (553 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (219 aa) |
