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| | Dgeo_0011 | Methionine gamma-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes: (2e-197) DegT/DnrJ/EryC1/StrS aminotransferase: (0.00017) aromatic amino acid beta-eliminating lyase/threonine aldolase: (0.0014); KEGG: dra:DR0921 methionine-gamma-lyase, ev=1e-158, 73% identity. (401 aa) |
| | Dgeo_0020 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (276 aa) |
| | Dgeo_0057 | 7-keto-8-aminopelargonate synthetase-like enzyme; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (396 aa) |
| | menG | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (239 aa) |
| | purC | KEGG: dra:DR0226 phosphoribosylaminoimidazole-succinocarboxamide synthase, ev=1e-108, 82% identity; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase: (1.5e-104); PFAM: SAICAR synthetase: (8.2e-90). (241 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (249 aa) |
| | Dgeo_0083 | KEGG: dra:DR0340 folylpolyglutamate synthase / dihydrofolate synthase, ev=1e-157, 73% identity; TIGRFAM: FolC bifunctional protein: (1.5e-116); PFAM: cytoplasmic peptidoglycan synthetases-like: (2.6e-06) Mur ligase, middle region: (8.4e-05). (404 aa) |
| | hisC | PFAM: aminotransferase, class I and II: (1.2e-48); KEGG: dra:DR2461 histidinol-phosphate aminotransferase, ev=1e-137, 67% identity; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (363 aa) |
| | Dgeo_0121 | PFAM: fatty acid desaturase, type 2: (8.6e-06); KEGG: bcz:BCZK2881 possible acyl-[acyl-carrier protein] desaturase, ev=3e-16, 27% identity. (364 aa) |
| | pdxY | Pyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (299 aa) |
| | Dgeo_0160 | PFAM: aldo/keto reductase: (1.5e-110); KEGG: ecc:c0414 2,5-diketo-D-gluconic acid reductase A, ev=2e-95, 60% identity. (284 aa) |
| | Dgeo_0198 | GTPase, G3E family; PFAM: cobalamin synthesis protein, P47K: (7.5e-65) cobalamin synthesis CobW-like: (1.8e-29); KEGG: dra:DR2408 CobW protein, putative, ev=1e-140, 80% identity. (322 aa) |
| | folE | PFAM: GTP cyclohydrolase I: (1.7e-55); KEGG: dra:DR0036 GTP cyclohydrolase I, ev=2e-82, 80% identity. (202 aa) |
| | Dgeo_0208 | Peptidase M20D, amidohydrolase; KEGG: dra:DR0339 N-acyl-L-amino acid amidohydrolase, putative, ev=1e-180, 78% identity; TIGRFAM: Peptidase M20D, amidohydrolase: (1.5e-151); PFAM: peptidase M20: (3.6e-50) peptidase dimerisation: (4.7e-05). (397 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (137 aa) |
| | Dgeo_0244 | PFAM: thioesterase superfamily: (9.4e-12); KEGG: dra:DR2298 hypothetical protein, ev=4e-40, 58% identity. (163 aa) |
| | Dgeo_0260 | PFAM: short-chain dehydrogenase/reductase SDR: (1.1e-05); KEGG: dra:DR1967 enoyl-acyl carrier protein reductase, ev=1e-112, 78% identity. (261 aa) |
| | Dgeo_0300 | 5-amino-6-(5-phosphoribosylamino)uracil reductase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (383 aa) |
| | Dgeo_0301 | TIGRFAM: riboflavin synthase, alpha subunit: (2.4e-59); PFAM: Lumazine-binding protein: (6.1e-25); KEGG: dra:DR0154 riboflavin synthase alpha chain, ev=2e-79, 68% identity. (214 aa) |
| | ribBA | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (403 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (388 aa) |
| | Dgeo_0348 | KEGG: syf:Synpcc7942_2420 serine O-acetyltransferase, ev=7e-29, 45% identity. (171 aa) |
| | Dgeo_0352 | PFAM: phosphoglucomutase/phosphomannomutase C terminal: (1.7e-05) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I: (1.2e-44) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II: (2.2e-07) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III: (1.4e-07); KEGG: dra:DRA0047 phosphomannomutase, ev=0.0, 78% identity. (475 aa) |
| | Dgeo_0363 | KEGG: dra:DR0268 putative sulfonate/nitrate/taurine transport system substrate-binding protein, ev=1e-129, 73% identity. (317 aa) |
| | Dgeo_0366 | PFAM: peptidase M20: (4.5e-31) peptidase dimerisation: (1.1e-26); KEGG: dra:DR2493 carboxypeptidase G2, ev=1e-148, 73% identity. (367 aa) |
| | Dgeo_0372 | PFAM: protein of unknown function DUF165: (2.1e-05); KEGG: dra:DR0380 hypothetical protein, ev=3e-67, 78% identity. (181 aa) |
| | Dgeo_0373 | KEGG: dra:DR0381 hypothetical protein, ev=3e-37, 67% identity. (124 aa) |
| | menC | Mandelate racemase/muconate lactonizing enzyme-like protein; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (369 aa) |
| | Dgeo_0396 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (302 aa) |
| | Dgeo_0397 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (124 aa) |
| | Dgeo_0398 | KEGG: dra:DR0170 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase, ev=3e-54, 69% identity; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase: (1.8e-50); PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK: (1e-47). (163 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (346 aa) |
| | Dgeo_0434 | TIGRFAM: malonyl CoA-acyl carrier protein transacylase: (1.8e-118); PFAM: acyl transferase region: (1.8e-14); KEGG: dra:DR1945 malonyl CoA-acyl carrier protein transacylase, ev=1e-126, 76% identity. (302 aa) |
| | Dgeo_0435 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (250 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (76 aa) |
| | Dgeo_0437 | Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa) |
| | mqnB | 5'-methylthioadenosine S-adenosylhomocysteine nucleosidase related protein; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (224 aa) |
| | Dgeo_0466 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (445 aa) |
| | Dgeo_0467 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (177 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (202 aa) |
| | Dgeo_0498 | TIGRFAM: glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase: (5.1e-44); PFAM: glutamine amidotransferase class-I: (1.1e-52) Anthranilate synthase component I and chorismate binding protein: (2.7e-120) Anthranilate synthase component I-like: (1.5e-05); KEGG: dra:DR0196 anthranilate synthase, ev=0.0, 77% identity. (642 aa) |
| | folD1 | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (336 aa) |
| | Dgeo_0529 | NADPH:quinone reductase; PFAM: Alcohol dehydrogenase, zinc-binding: (2.4e-37) Alcohol dehydrogenase GroES-like: (4.4e-24); KEGG: bcz:BCZK1920 quinone oxidoreductase, ev=7e-69, 43% identity. (325 aa) |
| | Dgeo_0536 | GTPase (G3E family); PFAM: cobalamin synthesis protein, P47K: (7.2e-66) cobalamin synthesis CobW-like: (2e-15); KEGG: bha:BH1790 hypothetical protein, ev=6e-69, 40% identity. (352 aa) |
| | Dgeo_0576 | PFAM: amidohydrolase: (3.3e-06); KEGG: dra:DR0824 hydrolase, putative, ev=1e-174, 77% identity. (388 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (497 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (516 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (336 aa) |
| | Dgeo_0601 | TIGRFAM: acetolactate synthase, small subunit: (3.6e-57); PFAM: amino acid-binding ACT: (8e-17); KEGG: dra:DR1517 acetolactate synthase, small subunit, ev=3e-67, 79% identity. (202 aa) |
| | Dgeo_0602 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type: (1.9e-252); PFAM: thiamine pyrophosphate enzyme-like TPP-binding: (1e-68) thiamine pyrophosphate enzyme, central region: (2e-55) thiamine pyrophosphate enzyme-like TPP binding region: (3.7e-96); KEGG: dra:DR1516 acetolactate synthase large subunit, ev=0.0, 81% identity. (573 aa) |
| | Dgeo_0610 | PFAM: homoserine dehydrogenase: (1.5e-46) homoserine dehydrogenase, NAD-binding: (2.2e-15); KEGG: dra:DR1278 homoserine dehydrogenase, ev=1e-138, 76% identity. (320 aa) |
| | Dgeo_0621 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (793 aa) |
| | Dgeo_0666 | TIGRFAM: ATP: (4.1e-106); PFAM: cobalamin adenosyltransferase: (8.8e-91); KEGG: dra:DR1638 hypothetical protein, ev=1e-78, 77% identity; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (296 aa) |
| | lysZ | N-acetylglutamate kinase; Catalyzes the phosphorylation of LysW-gamma-alpha- aminoadipate; Belongs to the acetylglutamate kinase family. LysZ subfamily. (279 aa) |
| | lysY | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of [LysW]- aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (349 aa) |
| | folD2 | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (289 aa) |
| | Dgeo_0710 | TIGRFAM: D-3-phosphoglycerate dehydrogenase: (4.8e-212); PFAM: amino acid-binding ACT: (6.3e-07) D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region: (9.6e-40) D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding: (8.5e-87); KEGG: dra:DR1291 D-3-phosphoglycerate dehydrogenase, ev=0.0, 86% identity. (542 aa) |
| | Dgeo_0713 | PFAM: aminotransferase, class V: (9.8e-12); KEGG: dra:DR0991 putative aminotransferase, ev=1e-175, 80% identity. (397 aa) |
| | argJ | N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (390 aa) |
| | Dgeo_0753 | PFAM: Alcohol dehydrogenase, zinc-binding: (6.9e-35) Alcohol dehydrogenase GroES-like: (3.1e-27); KEGG: dra:DR1061 NADPH quinone oxidoreductase, putative, ev=1e-134, 73% identity. (329 aa) |
| | Dgeo_0776 | Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (233 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (220 aa) |
| | hisZ | ATP phosphoribosyltransferase, Histidyl-tRNA synthetase-like protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (395 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (385 aa) |
| | Dgeo_0793 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding: (6.3e-67); KEGG: dra:DR1701 2-hydroxyacid dehydrogenase, putative, ev=1e-106, 64% identity. (296 aa) |
| | Dgeo_0807 | Homoserine O-acetyltransferase; PFAM: alpha/beta hydrolase fold: (0.00013); KEGG: bat:BAS4629 homoserine O-acetyltransferase, putative, ev=6e-36, 40% identity; Belongs to the AB hydrolase superfamily. MetX family. (359 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (263 aa) |
| | Dgeo_0847 | PFAM: phosphoribosyltransferase: (2e-05); KEGG: dra:DR0568 adenine phosphoribosyltransferase, ev=2e-75, 81% identity. (286 aa) |
| | Dgeo_0848 | Lycopene elongase; PFAM: UbiA prenyltransferase: (0.00041); KEGG: dra:DR0809 hypothetical protein, ev=1e-122, 78% identity. (292 aa) |
| | Dgeo_0898 | PFAM: NAD-dependent epimerase/dehydratase: (3.6e-19) 3-beta hydroxysteroid dehydrogenase/isomerase: (2e-12) dTDP-4-dehydrorhamnose reductase: (2.9e-07) NmrA-like: (0.00014) Male sterility-like: (1.5e-07); KEGG: dra:DR1980 putative NADH dehydrogenase (ubiquinone), ev=1e-102, 63% identity. (309 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (437 aa) |
| | queA | S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (366 aa) |
| | Dgeo_0947 | PFAM: bifunctional deaminase-reductase-like: (7.2e-33); KEGG: bce:BC3158 pyrimidine reductase, ev=5e-56, 56% identity. (180 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase: (1.1e-62); KEGG: dra:DR0424 imidazoleglycerol-phosphate dehydratase, ev=1e-89, 84% identity. (203 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (212 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (474 aa) |
| | Dgeo_0985 | TIGRFAM: glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase: (2.8e-86); PFAM: glutamine amidotransferase class-I: (4.1e-79); KEGG: dra:DR1766 anthranilate synthase component II, ev=2e-86, 77% identity. (213 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (351 aa) |
| | argD | PFAM: aminotransferase class-III: (6.4e-141); KEGG: dra:DRA0029 4-aminobutyrate aminotransferase, ev=0.0, 82% identity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (458 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (363 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (449 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (440 aa) |
| | Dgeo_1004 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes: (1.3e-135) aromatic amino acid beta-eliminating lyase/threonine aldolase: (0.0004); KEGG: tte:TTE1574 cystathionine gamma-synthase, ev=6e-83, 44% identity. (394 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (414 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (431 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (174 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (351 aa) |
| | Dgeo_1040 | Prephenate dehydrogenase; PFAM: amino acid-binding ACT: (9.4e-08) Prephenate dehydrogenase: (4.2e-81); KEGG: dra:DR1122 prephenate dehydrogenase, ev=1e-166, 83% identity. (370 aa) |
| | Dgeo_1099 | PFAM: glycosyl transferase, group 1: (7.8e-45); KEGG: dra:DR1555 hypothetical protein, ev=1e-170, 79% identity. (380 aa) |
| | pdxS | Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (303 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (201 aa) |
| | Dgeo_1114 | Serine--pyruvate transaminase; PFAM: aminotransferase, class V: (2.4e-14); KEGG: dra:DR1350 putative aminotransferase, ev=1e-170, 78% identity. (384 aa) |
| | Dgeo_1127 | KEGG: dra:DR1365 aspartate kinase, ev=0.0, 82% identity; TIGRFAM: aspartate kinase: (1.1e-148) aspartate kinase, monofunctional class: (1.6e-127); PFAM: aspartate/glutamate/uridylate kinase: (5.7e-67) amino acid-binding ACT: (1.9e-12); Belongs to the aspartokinase family. (470 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (244 aa) |
| | Dgeo_1151 | TIGRFAM: S6 modification enzyme RimK: (4.5e-160) Lysine biosynthesis enzyme LysX: (9.9e-188); PFAM: protein of unknown function DUF201: (0.00011) RimK-like ATP-grasp: (7e-59); KEGG: dra:DR2194 ribosomal protein S6 modification protein, ev=1e-143, 86% identity; Belongs to the RimK family. (292 aa) |
| | leuD-2 | Lysine biosynthesis protein, homoaconitate hydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (169 aa) |
| | leuC-2 | Lysine biosynthesis protein, homoaconitate hydratase family protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (331 aa) |
| | Dgeo_1177 | PFAM: aminotransferase class-III: (1.6e-89); KEGG: dra:DRA0121 aminotransferase, class III, ev=1e-179, 74% identity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa) |
| | Dgeo_1181 | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ. (100 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (142 aa) |
| | Dgeo_1192 | Hydroxymethylbutenyl pyrophosphate reductase lytB related protein. (262 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (529 aa) |
| | Dgeo_1204 | KEGG: dra:DR0451 glutamine synthase, ev=0.0, 80% identity; TIGRFAM: glutamine synthetase, type I: (4.1e-212); PFAM: glutamine synthetase, catalytic region: (4.7e-146) glutamine synthetase, beta-Grasp: (3.9e-07). (452 aa) |
| | Dgeo_1219 | Diamine aminotransferase apoenzyme; PFAM: aminotransferase class-III: (1.4e-78); KEGG: dra:DR1415 ornithine aminotransferase, ev=0.0, 77% identity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (492 aa) |
| | Dgeo_1229 | PFAM: Alcohol dehydrogenase, zinc-binding: (2.8e-16) Alcohol dehydrogenase GroES-like: (3.8e-16); KEGG: rpa:RPA4658 zinc-binding dehydrogenase (related to alcohol dehydrogenase, NADPH quinone oxidoreductase), ev=4e-96, 56% identity. (342 aa) |
| | ilvD | KEGG: nmu:Nmul_A0346 dihydroxy-acid dehydratase, ev=0.0, 71% identity; TIGRFAM: dihydroxy-acid dehydratase: (0); PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase: (0); Belongs to the IlvD/Edd family. (564 aa) |
| | Dgeo_1257 | TIGRFAM: Homocitrate synthase, fungi and archaea: (7.9e-185); PFAM: pyruvate carboxyltransferase: (1.9e-70); KEGG: dra:DR1238 homocitrate synthase, ev=0.0, 90% identity; Belongs to the alpha-IPM synthase/homocitrate synthase family. (389 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (360 aa) |
| | pgi | PFAM: phosphoglucose isomerase (PGI): (7.5e-272); KEGG: dra:DR1742 glucose-6-phosphate isomerase, ev=0.0, 77% identity. (649 aa) |
| | Dgeo_1317 | TIGRFAM: carboxynorspermidine decarboxylase: (9.3e-283); PFAM: Orn/DAP/Arg decarboxylase 2: (4.9e-29); KEGG: dra:DR1410 carboxynorspermidine decarboxylase, ev=0.0, 85% identity. (408 aa) |
| | comB | PFAM: 2-phosphosulfolactate phosphatase: (1.9e-79); KEGG: dra:DR1400 putative 2-phosphosulfolactate phosphatase, ev=6e-81, 67% identity; Belongs to the ComB family. (241 aa) |
| | Dgeo_1331 | TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit: (2.6e-67); PFAM: serine dehydratase alpha chain: (3.4e-152); KEGG: dra:DR0377 L-serine dehydratase, alpha subunit, ev=1e-149, 90% identity. (296 aa) |
| | Dgeo_1332 | TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit: (4.6e-59); PFAM: amino acid-binding ACT: (0.0055) serine dehydratase beta chain: (5.9e-65); KEGG: dra:DR0497 L-serine dehydratase, beta subunit, ev=1e-102, 85% identity. (221 aa) |
| | Dgeo_1334 | PFAM: prephenate dehydratase: (1.5e-50) amino acid-binding ACT: (0.00036); KEGG: dra:DR1147 prephenate dehydratase, ev=1e-121, 76% identity. (303 aa) |
| | Dgeo_1336 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1226 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (355 aa) |
| | lysK | N2-acetyl-L-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine. (358 aa) |
| | Dgeo_1407 | PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like: (1.1e-18) nitrite and sulphite reductase 4Fe-4S region: (2e-13); KEGG: dra:DRA0013 ferredoxin-nitrite reductase, ev=0.0, 78% identity. (521 aa) |
| | lysJ | N2-acetyl-L-lysine aminotransferase apoenzyme / acetylornithine aminotransferase apoenzyme; Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (415 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (116 aa) |
| | Dgeo_1451 | Threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase: (3.9e-148) aminotransferase, class I and II: (9.3e-06); KEGG: dra:DR1313 L-allo-threonine aldolase, ev=1e-150, 80% identity. (345 aa) |
| | Dgeo_1458 | PFAM: isocitrate/isopropylmalate dehydrogenase: (4.2e-127); KEGG: dra:DR1674 isocitrate dehydrogenase, ev=1e-164, 86% identity. (333 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (393 aa) |
| | Dgeo_1535 | PFAM: thioesterase superfamily: (2.1e-05); KEGG: pca:Pcar_2293 hypothetical protein, ev=4e-15, 38% identity. (154 aa) |
| | Dgeo_1536 | PFAM: transcriptional coactivator/pterin dehydratase: (1.2e-11); KEGG: nph:NP1766A homolog to 4A-hydroxytetrahydrobiopterin dehydratase, ev=1e-11, 37% identity. (118 aa) |
| | Dgeo_1547 | PFAM: peptidase M20: (5.3e-41) peptidase dimerisation: (7.3e-34); KEGG: dra:DR2025 ArgE/DapE/Acy1 family protein, ev=0.0, 80% identity. (455 aa) |
| | Dgeo_1550 | PFAM: phosphoribosyltransferase: (2e-10); KEGG: dra:DR0878 adenine phosphoribosyltransferase, putative, ev=1e-72, 77% identity. (176 aa) |
| | Dgeo_1572 | Chorismate mutase / 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase: (9.8e-193) Chorismate mutase, G-positive and Deinococcus: (3.8e-67); PFAM: Chorismate mutase: (8.8e-28) DAHP synthetase I/KDSA: (3.6e-129); KEGG: dra:DR1001 phospho-2-dehydro-3-deoxyheptonate aldolase / chorismate mutase, ev=1e-173, 85% identity. (379 aa) |
| | Dgeo_1586 | PFAM: beta-lactamase-like: (3.3e-10); KEGG: rba:RB11859 PhnP protein homolog-putative hydrolase, ev=4e-21, 34% identity. (267 aa) |
| | Dgeo_1587 | PFAM: Indole-3-glycerol phosphate synthase: (3e-77); KEGG: dra:DR1426 indole-3-glycerol phosphate synthase, ev=1e-91, 71% identity; Belongs to the TrpC family. (262 aa) |
| | Dgeo_1588 | KEGG: dra:DR1376 hypoxanthine-guanine phosphoribosyltransferase, ev=5e-81, 84% identity; TIGRFAM: hypoxanthine phosphoribosyltransferase: (4.1e-101); PFAM: phosphoribosyltransferase: (8.8e-32); Belongs to the purine/pyrimidine phosphoribosyltransferase family. (175 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (321 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (307 aa) |
| | Dgeo_1608 | KEGG: dra:DR0470 histidinol phosphatase, putative, ev=1e-118, 79% identity; TIGRFAM: Histidinol phosphate phosphatase, HisJ: (3.7e-109); PFAM: PHP-like: (5e-40); Belongs to the PHP hydrolase family. HisK subfamily. (263 aa) |
| | Dgeo_1657 | TIGRFAM: cysteine synthases: (8.1e-200) cysteine synthase A: (4.6e-208); PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit: (2.9e-117); KEGG: dra:DR0789 O-acetylserine (thiol)-lyase, ev=1e-153, 83% identity; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa) |
| | Dgeo_1669 | KEGG: sec:SC1300 putative aldehyde reductase, ev=5e-26, 51% identity. (130 aa) |
| | Dgeo_1696 | TIGRFAM: 4-hydroxybenzoyl-CoA thioesterase: (6.2e-27); PFAM: thioesterase superfamily: (3.8e-17); KEGG: dra:DR0902 hypothetical protein, ev=2e-47, 69% identity. (138 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (382 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (180 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (368 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (161 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (328 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase, USG-1 related protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | ilvA | Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa) |
| | Dgeo_1809 | TIGRFAM: riboflavin biosynthesis protein RibF: (7.1e-81); PFAM: Riboflavin kinase / FAD synthetase: (9.8e-47); KEGG: dra:DR1008 riboflavin kinase / FMN adenylyltransferase, ev=1e-136, 79% identity; Belongs to the ribF family. (303 aa) |
| | mqnD | Protein of unknown function DUF191; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (279 aa) |
| | Dgeo_1821 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (346 aa) |
| | Dgeo_1876 | TIGRFAM: fructose-1,6-bisphosphatase, class II: (2.5e-108); PFAM: GlpX: (5.6e-158); KEGG: ttj:TTHA1446 fructose-1,6-bisphosphatase, class II, ev=1e-127, 71% identity. (334 aa) |
| | Dgeo_1882 | PFAM: thioesterase superfamily: (1.9e-16); KEGG: bpm:BURPS1710b_1824 thioesterase family protein, ev=8e-47, 63% identity. (144 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (263 aa) |
| | hisI | PFAM: phosphoribosyl-AMP cyclohydrolase: (2.3e-45) phosphoribosyl-ATP pyrophosphohydrolase: (4.2e-36); KEGG: dra:DR0733 phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase, ev=1e-102, 86% identity; In the N-terminal section; belongs to the PRA-CH family. (218 aa) |
| | Dgeo_1919 | KEGG: dra:DRA0171 phosphomethylpyrimidine kinase, ev=7e-88, 71% identity; TIGRFAM: Phosphomethylpyrimidine kinase type-2: (1.9e-103); PFAM: Phosphomethylpyrimidine kinase type-1: (4.6e-120). (254 aa) |
| | thiG | Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (267 aa) |
| | Dgeo_1922 | TIGRFAM: thiamine biosynthesis protein ThiS: (6.9e-21); PFAM: thiamineS: (2.5e-11); KEGG: dra:DRA0173 thiamin biosynthesis ThiS, ev=2e-20, 71% identity. (62 aa) |
| | thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (221 aa) |
| | thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (609 aa) |
| | acpS | Phosphopantetheine--protein transferase domain; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (134 aa) |
| | Dgeo_1939 | TIGRFAM: thiamine pyrophosphokinase: (2.2e-45); PFAM: Thiamin pyrophosphokinase, catalytic region: (4.4e-27); KEGG: dra:DR0552 hypothetical protein, ev=4e-79, 74% identity. (212 aa) |
| | Dgeo_1978 | Domain of unknown function DUF1730; PFAM: HEAT: (0.0045) 4Fe-4S ferredoxin, iron-sulfur binding: (0.00021) Domain of unknown function DUF1730: (6.9e-12); SMART: PBS lyase HEAT-like repeat: (3.8e-06); KEGG: tth:TTC0112 iron-sulfur cluster-binding protein, ev=5e-88, 51% identity. (397 aa) |
| | mqnC | Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (393 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit: (6.3e-239); PFAM: glutamine amidotransferase class-I: (1.9e-65) Carbamoyl-phosphate synthase, small chain: (1.3e-72); KEGG: dra:DR0684 carbamoyl-phosphate synthase small chain, ev=0.0, 95% identity; Belongs to the CarA family. (394 aa) |
| | Dgeo_2061 | PFAM: GCN5-related N-acetyltransferase: (2.2e-14); KEGG: dra:DR0683 hypothetical protein, ev=1e-84, 85% identity. (176 aa) |
| | Dgeo_2062 | PFAM: GCN5-related N-acetyltransferase: (1.4e-08); KEGG: dra:DR0682 hypothetical protein, ev=9e-59, 69% identity. (156 aa) |
| | Dgeo_2063 | PFAM: GCN5-related N-acetyltransferase: (8.5e-13); KEGG: dra:DR0681 hypothetical protein, ev=4e-57, 68% identity. (168 aa) |
| | argH | TIGRFAM: argininosuccinate lyase: (4.4e-244); PFAM: fumarate lyase: (6e-85); KEGG: dra:DR0678 argininosuccinate lyase, ev=0.0, 87% identity. (465 aa) |
| | argG | PFAM: argininosuccinate synthase: (6.4e-215); KEGG: dra:DR0674 arginosuccinate synthase, ev=0.0, 90% identity; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (414 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit: (0); PFAM: phosphoribosylglycinamide synthetase: (0.0013) protein of unknown function DUF201: (0.0017) Carbamoyl-phosphate synthase L chain, ATP-binding: (5.1e-23) Carbamoyl-phosphate synthetase large chain, oligomerisation: (2.8e-60) Carbamoyl-phosphate synthetase large chain-like: (1.3e-29); KEGG: dra:DR0668 carbamoyl-phosphate synthase large chain, ev=0.0, 89% identity. (1029 aa) |
| | mqnE | Thiamine biosynthesis enzyme ThiH, Radical SAM superfamily enzyme; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (376 aa) |
| | mqnA | Protein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (294 aa) |
| | Dgeo_2129 | Precorrin-2 dehydrogenase; TIGRFAM: siroheme synthase, N-terminal domain: (1.4e-19); KEGG: cvi:CV0813 uroporphyrin-III C-methyltransferase, ev=2e-23, 46% identity. (188 aa) |
| | hisA | TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase: (1e-115); PFAM: histidine biosynthesis: (1.4e-96); KEGG: dra:DR2495 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, ev=1e-104, 82% identity. (243 aa) |
| | Dgeo_2163 | KEGG: dra:DR2500 hypothetical protein, ev=9e-52, 68% identity. (198 aa) |
| | Dgeo_2173 | Phosphocarrier protein HPr / PTS system D-fructose-specific IIA component (F1P-forming), Frc family; TIGRFAM: Phosphoenolpyruvate-protein phosphotransferase: (4.6e-148); PFAM: phosphocarrier HPr protein: (1.8e-09) PEP-utilizing enzyme: (2e-132) phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2: (1.2e-60) PEP-utilising enzyme, mobile region: (5.7e-24) PEP-utilising enzyme-like: (1.5e-23); KEGG: dra:DRB0075 PTS system, multiphosphoryl transfer protein, domains EI, HPr, and fructose, ev=0.0, 74% identity; TC 4.A.2.1.1. (835 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (306 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (284 aa) |
| | Dgeo_2213 | Nucleotide-diphospho-sugar transferase superfamily protein; KEGG: dra:DR2329 hypothetical protein, ev=8e-93, 69% identity. (264 aa) |
| | Dgeo_2240 | PFAM: Carboxylyase-related protein: (2.1e-162); KEGG: dra:DR0332 3-octaprenyl-4-hydroxybenzoate carboxy-lyase, ev=0.0, 75% identity; Belongs to the UbiD family. (621 aa) |
| | Dgeo_2246 | HMGL-like domain protein; PFAM: pyruvate carboxyltransferase: (2.7e-11); KEGG: cac:CAC0970 isopropylmalate synthase, ev=4e-71, 38% identity. (436 aa) |
| | Dgeo_2252 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (345 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (317 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI): (6.9e-40); KEGG: dra:DR0123 phosphoribosylanthranilate isomerase, ev=1e-67, 66% identity; Belongs to the TrpF family. (214 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (153 aa) |
| | Dgeo_2322 | TIGRFAM: 4-hydroxybenzoate polyprenyltransferase, putative: (1.3e-157); PFAM: UbiA prenyltransferase: (2.3e-66); KEGG: dra:DR0851 4-hydroxybenzoate octaprenyltransferase, ev=1e-141, 82% identity; Belongs to the UbiA prenyltransferase family. (319 aa) |
