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eno eno Dgeo_0005 Dgeo_0005 Dgeo_0242 Dgeo_0242 Dgeo_0353 Dgeo_0353 Dgeo_0575 Dgeo_0575 Dgeo_0621 Dgeo_0621 Dgeo_1133 Dgeo_1133 pgk pgk tpiA tpiA Dgeo_1149 Dgeo_1149 pckA pckA pgi pgi pdhA pdhA Dgeo_1562 Dgeo_1562 pfkA pfkA Dgeo_1750 Dgeo_1750 acsA acsA Dgeo_1875 Dgeo_1875 Dgeo_1876 Dgeo_1876 Dgeo_1886 Dgeo_1886 Dgeo_1887 Dgeo_1887 Dgeo_2023 Dgeo_2023 Dgeo_2083 Dgeo_2083 Dgeo_2228 Dgeo_2228 apgM apgM Dgeo_2323 Dgeo_2323 Dgeo_2341 Dgeo_2341
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (422 aa)
Dgeo_0005PFAM: pyruvate kinase: (9.6e-166); KEGG: dra:DR2635 pyruvate kinase, ev=0.0, 86% identity; Belongs to the pyruvate kinase family. (482 aa)
Dgeo_0242ROK domain protein; PFAM: ROK: (1.7e-54); KEGG: dra:DR2296 glucokinase, ev=1e-128, 76% identity. (320 aa)
Dgeo_0353TIGRFAM: Dihydrolipoamide dehydrogenase: (1.1e-231); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (3e-29) glucose-inhibited division protein A: (0.00016) fumarate reductase/succinate dehydrogenase flavoprotein-like: (0.0029) pyridine nucleotide-disulphide oxidoreductase dimerisation region: (6.2e-64) HI0933-like protein: (0.001); KEGG: dra:DR2526 lipoamide dehydrogenase E3 component, ev=0.0, 83% identity. (468 aa)
Dgeo_0575ROK domain protein; PFAM: ROK: (5.5e-08); KEGG: dra:DR0823 ROK family protein, ev=1e-104, 77% identity. (270 aa)
Dgeo_0621Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (793 aa)
Dgeo_1133KEGG: dra:DR1343 glyceraldehyde 3-phosphate dehydrogenase, ev=1e-158, 83% identity; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I: (1.8e-183); PFAM: glyceraldehyde 3-phosphate dehydrogenase: (1.3e-98); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
pgkPFAM: phosphoglycerate kinase: (1.8e-194); KEGG: dra:DR1342 phosphoglycerate kinase, ev=1e-172, 77% identity; Belongs to the phosphoglycerate kinase family. (389 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (244 aa)
Dgeo_1149Glucose dehydrogenase, Gcd and cytochrome c-like domain; PFAM: Pyrrolo-quinoline quinone: (1.4e-06) cytochrome c, class I: (0.0084); KEGG: bja:blr6207 probable quinoprotein ethanol dehydrogenase precursor, ev=8e-85, 37% identity. (678 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (529 aa)
pgiPFAM: phosphoglucose isomerase (PGI): (7.5e-272); KEGG: dra:DR1742 glucose-6-phosphate isomerase, ev=0.0, 77% identity. (649 aa)
pdhA2-oxoisovalerate dehydrogenase, OdbA; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (361 aa)
Dgeo_15622-oxoisovalerate dehydrogenase, OdbB; PFAM: Transketolase, central region: (3.3e-66) Transketolase-like: (6.9e-47); KEGG: ttj:TTHA0938 pyruvate dehydrogenase E1 component, beta subunit, ev=1e-125, 67% identity. (334 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (336 aa)
Dgeo_1750PFAM: AMP-dependent synthetase and ligase: (5.5e-117); KEGG: dra:DR0460 acetyl-CoA synthase, ev=0.0, 78% identity. (636 aa)
acsAAcetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (655 aa)
Dgeo_1875TIGRFAM: phosphoglucomutase, alpha-D-glucose phosphate-specific: (0); PFAM: phosphoglucomutase/phosphomannomutase C terminal: (2.9e-12) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I: (1.1e-35) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II: (2.5e-17) phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III: (1.9e-32); KEGG: pca:Pcar_1989 phosphoglucomutase, alpha-D-glucose phosphate-specific, ev=0.0, 61% identity. (547 aa)
Dgeo_1876TIGRFAM: fructose-1,6-bisphosphatase, class II: (2.5e-108); PFAM: GlpX: (5.6e-158); KEGG: ttj:TTHA1446 fructose-1,6-bisphosphatase, class II, ev=1e-127, 71% identity. (334 aa)
Dgeo_1886Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (594 aa)
Dgeo_18872-oxo-acid dehydrogenase E1 component, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (902 aa)
Dgeo_2023PFAM: Aldose 1-epimerase: (1.2e-31); KEGG: dra:DR0747 aldose epimerase family protein, ev=1e-120, 70% identity. (298 aa)
Dgeo_2083Fructose-1,6-bisphosphate aldolase, class II; KEGG: dra:DR1589 fructose-bisphosphate aldolase, ev=1e-152, 88% identity; TIGRFAM: ketose-bisphosphate aldolases: (5.7e-100) fructose-1,6-bisphosphate aldolase, class II: (6.8e-209); PFAM: ketose-bisphosphate aldolase, class-II: (1.9e-127). (308 aa)
Dgeo_2228PFAM: Phosphoglycerate mutase: (1.1e-37); KEGG: dra:DR0602 phosphoglycerate mutase-related protein, ev=1e-70, 67% identity. (227 aa)
apgMPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (408 aa)
Dgeo_2323TIGRFAM: Dihydrolipoamide dehydrogenase: (3.5e-224); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (4.7e-29) pyridine nucleotide-disulphide oxidoreductase dimerisation region: (2.7e-62); KEGG: dra:DR2370 pyruvate dehydrogenase complex, dihydrolipoamide dehydrogenase E3 component, putative, ev=0.0, 82% identity. (467 aa)
Dgeo_2341Dihydrolipoamide acyltransferase, (E2) component; PFAM: biotin/lipoyl attachment: (4e-24) catalytic domain of components of various dehydrogenase complexes: (6.2e-128) E3 binding: (4.3e-18); KEGG: dra:DR0032 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase), ev=0.0, 69% identity. (516 aa)
Your Current Organism:
Deinococcus geothermalis
NCBI taxonomy Id: 319795
Other names: D. geothermalis DSM 11300, Deinococcus geothermalis AG-3a, Deinococcus geothermalis CIP 105573, Deinococcus geothermalis DSM 11300, Deinococcus geothermalis str. DSM 11300, Deinococcus geothermalis strain DSM 11300
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