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glyA glyA Dgeo_0353 Dgeo_0353 Dgeo_0623 Dgeo_0623 Dgeo_0624 Dgeo_0624 Dgeo_0755 Dgeo_0755 Dgeo_0862 Dgeo_0862 Dgeo_1114 Dgeo_1114 Dgeo_1203 Dgeo_1203 Dgeo_1204 Dgeo_1204 Dgeo_1287 Dgeo_1287 Dgeo_1320 Dgeo_1320 Dgeo_1441 Dgeo_1441 purU purU Dgeo_1526 Dgeo_1526 kynB kynB Dgeo_1541 Dgeo_1541 Dgeo_1682 Dgeo_1682 Dgeo_1750 Dgeo_1750 acsA acsA Dgeo_1790 Dgeo_1790 Dgeo_1883 Dgeo_1883 gcvT gcvT gcvH gcvH gcvP gcvP mdh mdh Dgeo_2245 Dgeo_2245 Dgeo_2323 Dgeo_2323
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
Dgeo_0353TIGRFAM: Dihydrolipoamide dehydrogenase: (1.1e-231); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (3e-29) glucose-inhibited division protein A: (0.00016) fumarate reductase/succinate dehydrogenase flavoprotein-like: (0.0029) pyridine nucleotide-disulphide oxidoreductase dimerisation region: (6.2e-64) HI0933-like protein: (0.001); KEGG: dra:DR2526 lipoamide dehydrogenase E3 component, ev=0.0, 83% identity. (468 aa)
Dgeo_0623Glycolate oxidase, Fe-S subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding: (4.1e-05) protein of unknown function DUF224, cysteine-rich region: (2.3e-20); KEGG: dra:DR1730 glycolate oxidase, iron-sulfur subunit, ev=0.0, 85% identity. (425 aa)
Dgeo_0624Glycolate oxidase subunit, GlcD; PFAM: FAD linked oxidase-like: (2.4e-89); KEGG: dra:DR1731 glycolate oxidase subunit GlcD, ev=0.0, 80% identity. (482 aa)
Dgeo_0755PFAM: Thiolase: (8.4e-92); KEGG: dra:DR1428 acetyl-CoA acetyltransferase, ev=0.0, 85% identity; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
Dgeo_0862KEGG: dra:DR1189 methylmalonyl-CoA mutase, alpha subunit, chain A, ev=0.0, 91% identity; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain: (8.1e-224); PFAM: methylmalonyl-CoA mutase: (1.8e-235). (548 aa)
Dgeo_1114Serine--pyruvate transaminase; PFAM: aminotransferase, class V: (2.4e-14); KEGG: dra:DR1350 putative aminotransferase, ev=1e-170, 78% identity. (384 aa)
Dgeo_1203PFAM: glutamine synthetase, catalytic region: (1.2e-16); KEGG: dra:DR2033 glutamine synthase, ev=0.0, 77% identity. (718 aa)
Dgeo_1204KEGG: dra:DR0451 glutamine synthase, ev=0.0, 80% identity; TIGRFAM: glutamine synthetase, type I: (4.1e-212); PFAM: glutamine synthetase, catalytic region: (4.7e-146) glutamine synthetase, beta-Grasp: (3.9e-07). (452 aa)
Dgeo_1287TIGRFAM: isocitrate lyase: (6.6e-185); PFAM: isocitrate lyase and phosphorylmutase: (1.6e-236); KEGG: dra:DR0828 isocitrate lyase, ev=0.0, 89% identity. (443 aa)
Dgeo_1320KEGG: dra:DR1084 methylmalonyl-CoA mutase, beta subunit, ev=0.0, 85% identity; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain: (5.2e-273) methylmalonyl-CoA mutase C-terminal domain: (6.1e-60); PFAM: methylmalonyl-CoA mutase: (0) cobalamin B12-binding: (7.7e-28). (722 aa)
Dgeo_1441PFAM: Thiolase: (6.2e-154); KEGG: dra:DR1072 acetyl-CoA acetyltransferase, ev=0.0, 82% identity; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (296 aa)
Dgeo_1526KEGG: dra:DR0757 citrate synthase, ev=0.0, 84% identity; TIGRFAM: 2-methylcitrate synthase/citrate synthase II: (1.1e-247); PFAM: Citrate synthase: (4.7e-142); Belongs to the citrate synthase family. (390 aa)
kynBKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. (213 aa)
Dgeo_1541methylmalonyl-CoA mutase, alpha subunit; TIGRFAM: methylmalonyl-CoA mutase C-terminal domain: (5.3e-45); PFAM: cobalamin B12-binding: (1.7e-41); KEGG: dra:DR2032 methylmalonyl-CoA mutase, alpha subunit, chain B, ev=1e-60, 85% identity. (151 aa)
Dgeo_1682Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (906 aa)
Dgeo_1750PFAM: AMP-dependent synthetase and ligase: (5.5e-117); KEGG: dra:DR0460 acetyl-CoA synthase, ev=0.0, 78% identity. (636 aa)
acsAAcetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (655 aa)
Dgeo_1790PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase: (2.8e-11); KEGG: dra:DR2022 hypothetical protein, ev=3e-59, 77% identity. (158 aa)
Dgeo_1883PFAM: Thiolase: (7e-144); KEGG: dra:DR1960 acetyl-CoA acetyltransferase, ev=1e-163, 73% identity; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (374 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (120 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (334 aa)
Dgeo_2245Citrate synthase; PFAM: regulatory protein, MerR: (5.2e-07) Citrate synthase: (3.6e-14); KEGG: mlo:mlr3843 citrate synthase II, ev=9e-72, 43% identity. (402 aa)
Dgeo_2323TIGRFAM: Dihydrolipoamide dehydrogenase: (3.5e-224); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase: (4.7e-29) pyridine nucleotide-disulphide oxidoreductase dimerisation region: (2.7e-62); KEGG: dra:DR2370 pyruvate dehydrogenase complex, dihydrolipoamide dehydrogenase E3 component, putative, ev=0.0, 82% identity. (467 aa)
Your Current Organism:
Deinococcus geothermalis
NCBI taxonomy Id: 319795
Other names: D. geothermalis DSM 11300, Deinococcus geothermalis AG-3a, Deinococcus geothermalis CIP 105573, Deinococcus geothermalis DSM 11300, Deinococcus geothermalis str. DSM 11300, Deinococcus geothermalis strain DSM 11300
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