Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Dgeo_1336 | Dgeo_1546 | Dgeo_1336 | Dgeo_1546 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. | 0.918 |
| Dgeo_1336 | Dgeo_1903 | Dgeo_1336 | Dgeo_1903 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: 5-formyltetrahydrofolate cyclo-ligase: (5.4e-38); KEGG: dra:DR1815 hypothetical protein, ev=6e-57, 65% identity. | 0.418 |
| Dgeo_1336 | fmt | Dgeo_1336 | Dgeo_2291 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.931 |
| Dgeo_1336 | folD1 | Dgeo_1336 | Dgeo_0514 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.498 |
| Dgeo_1336 | folD2 | Dgeo_1336 | Dgeo_0699 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.498 |
| Dgeo_1336 | gcvT | Dgeo_1336 | Dgeo_1905 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.956 |
| Dgeo_1336 | glyA | Dgeo_1336 | Dgeo_0221 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
| Dgeo_1336 | purH | Dgeo_1336 | Dgeo_0513 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: dra:DR0868 phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.911 |
| Dgeo_1336 | purU | Dgeo_1336 | Dgeo_1488 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.915 |
| Dgeo_1336 | thyX | Dgeo_1336 | Dgeo_2027 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.916 |
| Dgeo_1546 | Dgeo_1336 | Dgeo_1546 | Dgeo_1336 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.918 |
| Dgeo_1546 | Dgeo_1903 | Dgeo_1546 | Dgeo_1903 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. | PFAM: 5-formyltetrahydrofolate cyclo-ligase: (5.4e-38); KEGG: dra:DR1815 hypothetical protein, ev=6e-57, 65% identity. | 0.915 |
| Dgeo_1546 | fmt | Dgeo_1546 | Dgeo_2291 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.940 |
| Dgeo_1546 | folD1 | Dgeo_1546 | Dgeo_0514 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.959 |
| Dgeo_1546 | folD2 | Dgeo_1546 | Dgeo_0699 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.955 |
| Dgeo_1546 | gcvT | Dgeo_1546 | Dgeo_1905 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.932 |
| Dgeo_1546 | glyA | Dgeo_1546 | Dgeo_0221 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
| Dgeo_1546 | purH | Dgeo_1546 | Dgeo_0513 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: dra:DR0868 phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.999 |
| Dgeo_1546 | purU | Dgeo_1546 | Dgeo_1488 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.932 |
| Dgeo_1546 | thyX | Dgeo_1546 | Dgeo_2027 | PFAM: formyl transferase-like: (3.1e-40); KEGG: dra:DR2026 phosphoribosylglycinamide formyltransferase, ev=1e-78, 80% identity. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.915 |
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