(101 nodes) mRNA Splicing network (Parastagonospora nodorum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SNOG_16397	Uncharacterized protein. (308 aa)
	SNOG_16410	Uncharacterized protein. (332 aa)
	SNOG_16088	MFAP1 domain-containing protein. (420 aa)
	SNOG_15981	WD_REPEATS_REGION domain-containing protein. (503 aa)
	SNOG_15992	RRM domain-containing protein. (386 aa)
	SNOG_15866	RRM domain-containing protein. (118 aa)
	SNOG_15377	PPIase cyclophilin-type domain-containing protein. (497 aa)
	SNOG_15008	WD_REPEATS_REGION domain-containing protein. (457 aa)
	SNOG_15022	SF3A2 domain-containing protein. (218 aa)
	SNOG_15043	Uncharacterized protein. (372 aa)
	SNOG_14954	Uncharacterized protein. (489 aa)
	SNOG_14581	Uncharacterized protein. (271 aa)
	SNOG_14113	DUF1716 domain-containing protein. (609 aa)
	SNOG_14169	WD_REPEATS_REGION domain-containing protein. (430 aa)
	SNOG_13797	Uncharacterized protein. (237 aa)
	SNOG_13779	Uncharacterized protein. (108 aa)
	SNOG_13667	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (97 aa)
	SNOG_13342	Uncharacterized protein. (1331 aa)
	SNOG_12999	Uncharacterized protein. (322 aa)
	SNOG_12847	DUF2040 domain-containing protein. (408 aa)
	SNOG_12587	Uncharacterized protein. (165 aa)
	SNOG_12447	Uncharacterized protein. (295 aa)
	SNOG_12293	Uncharacterized protein. (240 aa)
	SNOG_12287	Uncharacterized protein. (572 aa)
	SNOG_11947	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family. (137 aa)
	SNOG_11880	RBR-type E3 ubiquitin transferase. (684 aa)
	SNOG_11874	SKIP_SNW domain-containing protein. (557 aa)
	SNOG_11761	Splicing factor subunit; Belongs to the SF3B5 family. (84 aa)
	SNOG_11653	Uncharacterized protein. (550 aa)
	SNOG_11512	Uncharacterized protein. (214 aa)
	SNOG_11457	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (341 aa)
	SNOG_11135	Matrin-type domain-containing protein. (518 aa)
	SNOG_10893	Uncharacterized protein. (287 aa)
	SNOG_10761	Uncharacterized protein. (129 aa)
	SNOG_10692	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
	SNOG_10614	Uncharacterized protein. (562 aa)
	SNOG_10452	Small nuclear ribonucleoprotein Sm D2. (133 aa)
	SNOG_10227	Small nuclear ribonucleoprotein Sm D3. (117 aa)
	SNOG_10226	Uncharacterized protein. (286 aa)
	SNOG_10143	Uncharacterized protein. (1342 aa)
	SNOG_09372	Uncharacterized protein. (141 aa)
	SNOG_09247	Uncharacterized protein. (306 aa)
	SNOG_09240	Uncharacterized protein. (564 aa)
	SNOG_08990	Uncharacterized protein. (492 aa)
	SNOG_08932	Uncharacterized protein. (204 aa)
	SNOG_08930	Uncharacterized protein. (853 aa)
	SNOG_08770	Uncharacterized protein. (674 aa)
	SNOG_08693	Uncharacterized protein. (1217 aa)
	SNOG_08662	Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family. (132 aa)
	SNOG_08444	RRM domain-containing protein. (375 aa)
	SNOG_08251	Pre-mRNA-splicing factor; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. (1468 aa)
	SNOG_07749	Sde2_N_Ubi domain-containing protein. (272 aa)
	SNOG_07619	Uncharacterized protein. (674 aa)
	SNOG_07592	Uncharacterized protein. (474 aa)
	SNOG_07410	RRM domain-containing protein. (155 aa)
	SNOG_07289	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (169 aa)
	SNOG_07203	Isochorismatase domain-containing protein. (298 aa)
	SNOG_07183	Cir_N domain-containing protein. (350 aa)
	SNOG_07181	Uncharacterized protein. (285 aa)
	SNOG_07162	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (165 aa)
	SNOG_07089	Uncharacterized protein. (783 aa)
	SNOG_06985	Uncharacterized protein. (680 aa)
	SNOG_06984	Nop domain-containing protein. (560 aa)
	PRP5	Pre-mRNA-processing ATP-dependent RNA helicase PRP5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1184 aa)
	SNOG_06737	U1-type domain-containing protein. (274 aa)
	SNOG_06689	Uncharacterized protein. (169 aa)
	SNOG_06486	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (127 aa)
	SNOG_06361	U1-type domain-containing protein. (214 aa)
	SNOG_05632	Uncharacterized protein. (205 aa)
	SNOG_05513	Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family. (143 aa)
	SNOG_05511	Ubiquitin-like domain-containing protein. (240 aa)
	SNOG_05408	Uncharacterized protein. (238 aa)
	SNOG_04746	Tr-type G domain-containing protein. (988 aa)
	SNOG_04637	Uncharacterized protein. (980 aa)
	SNOG_04483	WD_REPEATS_REGION domain-containing protein. (500 aa)
	SNOG_04440	Small nuclear ribonucleoprotein G. (84 aa)
	SNOG_04437	Uncharacterized protein. (2208 aa)
	SNOG_04397	SF3b1 domain-containing protein. (1207 aa)
	SNOG_04336	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
	SNOG_04220	PWI domain-containing protein. (372 aa)
	PRP28	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (746 aa)
	SNOG_03665	G-patch_2 domain-containing protein. (447 aa)
	SNOG_03555	Sm domain-containing protein. (214 aa)
	SNOG_03502	RRM domain-containing protein. (177 aa)
	SNOG_03343	Uncharacterized protein. (77 aa)
	SNOG_03315	RED_N domain-containing protein. (565 aa)
	SNOG_03304	Uncharacterized protein. (857 aa)
	SNOG_03051	Uncharacterized protein. (1278 aa)
	SNOG_03048	Uncharacterized protein. (932 aa)
	SNOG_03018	RRM domain-containing protein. (373 aa)
	SNOG_02443	CPSF_A domain-containing protein. (1246 aa)
	SNOG_02129	Uncharacterized protein. (328 aa)
	SNOG_01905	Uncharacterized protein. (362 aa)
	SNOG_01768	PSP domain-containing protein. (568 aa)
	SNOG_01720	Uncharacterized protein. (181 aa)
	SNOG_01575	Cwf21 domain-containing protein. (183 aa)
	SNOG_01020	ANK_REP_REGION domain-containing protein. (851 aa)
	SNOG_01003	MI domain-containing protein. (717 aa)
	SNOG_00716	WD_REPEATS_REGION domain-containing protein. (450 aa)
	SNOG_00449	MPN domain-containing protein. (2308 aa)
	SNOG_00186	Uncharacterized protein. (503 aa)

Your Current Organism:

Parastagonospora nodorum

NCBI taxonomy Id: 321614
Other names: P. nodorum SN15, Parastagonospora nodorum SN15, Phaeosphaeria nodorum SN15

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PRP28	SNOG_00186	Q0UWC8	Q0V728	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	Uncharacterized protein.	0.768
PRP28	SNOG_00449	Q0UWC8	Q0V6B4	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	MPN domain-containing protein.	0.999
PRP28	SNOG_00716	Q0UWC8	Q0V5J8	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	WD_REPEATS_REGION domain-containing protein.	0.661
PRP28	SNOG_01003	Q0UWC8	Q0V4R1	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	MI domain-containing protein.	0.665
PRP28	SNOG_01020	Q0UWC8	Q0V4P4	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	ANK_REP_REGION domain-containing protein.	0.603
PRP28	SNOG_01768	Q0UWC8	Q0V2J6	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	PSP domain-containing protein.	0.788
PRP28	SNOG_01905	Q0UWC8	Q0V259	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	Uncharacterized protein.	0.615
PRP28	SNOG_02443	Q0UWC8	Q0V0M1	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	CPSF_A domain-containing protein.	0.761
PRP28	SNOG_03048	Q0UWC8	Q0UYW6	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	Uncharacterized protein.	0.998
PRP28	SNOG_03304	Q0UWC8	Q0UY60	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	Uncharacterized protein.	0.589
PRP28	SNOG_03502	Q0UWC8	Q0UXL2	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	RRM domain-containing protein.	0.531
PRP28	SNOG_03555	Q0UWC8	Q0UXF9	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	Sm domain-containing protein.	0.931
PRP28	SNOG_04397	Q0UWC8	Q0UV17	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	SF3b1 domain-containing protein.	0.851
PRP28	SNOG_04437	Q0UWC8	Q0UUX7	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	Uncharacterized protein.	0.986
PRP28	SNOG_04440	Q0UWC8	Q0UUX3	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	Small nuclear ribonucleoprotein G.	0.974
PRP28	SNOG_04483	Q0UWC8	Q0UUT1	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	WD_REPEATS_REGION domain-containing protein.	0.937
PRP28	SNOG_04637	Q0UWC8	Q0UUC7	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	Uncharacterized protein.	0.769
PRP28	SNOG_04746	Q0UWC8	Q0UU18	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	Tr-type G domain-containing protein.	0.998
PRP28	SNOG_05513	Q0UWC8	Q0URV1	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family.	0.991
PRP28	SNOG_06361	Q0UWC8	Q0UPF3	Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).	U1-type domain-containing protein.	0.587