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dnaN dnaN holA holA pgsA pgsA polA polA tmk tmk AYWB_086 AYWB_086 AYWB_090 AYWB_090 dnaG dnaG dnaX dnaX AYWB_119 AYWB_119 pssA pssA dnaE dnaE aceF aceF plsX plsX dnaG-2 dnaG-2 tmk-2 tmk-2 AYWB_207 AYWB_207 AYWB_208 AYWB_208 dnaG-3 dnaG-3 tmk-3 tmk-3 dacA dacA AYWB_246 AYWB_246 AYWB_249 AYWB_249 qri7 qri7 tmk-4 tmk-4 dnaG-4 dnaG-4 trmD trmD csdB csdB polC polC plsY plsY acpS acpS dam dam lplA lplA AYWB_415 AYWB_415 smtA smtA asm asm plsC plsC thyA thyA pykF pykF pfkA pfkA miaA miaA gidB gidB rpoC rpoC rpoB rpoB spoU spoU pnp pnp cmk cmk tpm tpm holB holB tmk-5 tmk-5 rpoA rpoA adk adk rplB rplB glyA glyA pgk pgk cdsA cdsA pyrH pyrH ackA ackA spoU-2 spoU-2 thiI thiI udk udk spoT spoT trmU trmU tdk tdk pcnB pcnB pduL pduL ksgA ksgA rsmH rsmH AYWB_653 AYWB_653 rpoZ rpoZ gmk gmk
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dnaNDNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (378 aa)
holADNA polymerase III, delta subunit. (323 aa)
pgsACDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase. (215 aa)
polADNA polymerase I. (847 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa)
AYWB_086Conserved hypothetical protein; Similar to a fragment of DNA primase. (175 aa)
AYWB_090Predicted kinase related to dihydroxyacetone kinase. (571 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (604 aa)
dnaXDNA polymerase III, gamma/tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (653 aa)
AYWB_119Conserved hypothetical protein. (169 aa)
pssACDP-diacylglycerol-serine O-phosphatidyltransferase. (244 aa)
dnaEDNA polymerase III alpha subunit. (916 aa)
aceFDihydrolipoamide acyltransferase component. (417 aa)
plsXFatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (362 aa)
dnaG-2DNA primase. (441 aa)
tmk-2Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa)
AYWB_207Conserved hypothetical protein; Similar to a fragment of adenine-specific methyltransferase. (125 aa)
AYWB_208Conserved hypothetical protein; Similar to a fragment of adenine-specific methyltransferase. (107 aa)
dnaG-3DNA primase. (441 aa)
tmk-3Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa)
dacAConserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (263 aa)
AYWB_246Conserved hypothetical protein; Similar to a fragment of dihydropteroate synthase. (135 aa)
AYWB_249Conserved hypothetical protein; Similar to a fragment of 7,8-dihydro-6-hydroxymethyldihydropteridine pyrophosphokinase. (85 aa)
qri7O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction (By similarity); Belongs to the KAE1 / TsaD family. (274 aa)
tmk-4Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (209 aa)
dnaG-4DNA primase. (441 aa)
trmDtRNA (Guanine-N1) -methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (242 aa)
csdBCysteine desulfhydrase. (406 aa)
polCDNA polymerase III alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1572 aa)
plsYConserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (231 aa)
acpSHolo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa)
damAdenine-specific methyltransferase. (294 aa)
lplALipoate-protein ligase A. (338 aa)
AYWB_415Dimethyladenosine transferase. (450 aa)
smtASAM-dependent methyltransferase. (205 aa)
asmN6-adenine-specific methylase. (186 aa)
plsC1-acyl-sn-glycerol-3-phosphate acyltransferase. (269 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (288 aa)
pykFPyruvate kinase; Belongs to the pyruvate kinase family. (446 aa)
pfkA6-phophofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (328 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (291 aa)
gidBGlucose inhibited division protein B; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (212 aa)
rpoCDNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1353 aa)
rpoBDNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1273 aa)
spoU23S rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (235 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (715 aa)
cmkCytidylate kinase. (223 aa)
tpmTetrapyrrole (Corrin/Porphyrin) methylase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (285 aa)
holBDNA polymerase III, delta prime subunit. (328 aa)
tmk-5Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (207 aa)
rpoADNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (330 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
rplBLSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (276 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (429 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (398 aa)
cdsAPhosphatidate cytidylyltransferase; Belongs to the CDS family. (303 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (410 aa)
spoU-223S rRNA methyltransferase. (234 aa)
thiIThiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (434 aa)
udkUridine kinase. (546 aa)
spoTGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (745 aa)
trmUtRNA (5-methylaminomethyl-2-thioruidylate) methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (378 aa)
tdkThymidine kinase. (233 aa)
pcnBpoly(A) polymerase. (407 aa)
pduLPropanediol utilisation protein PduL. (195 aa)
ksgADimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (268 aa)
rsmHConserved hypothetical protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (202 aa)
AYWB_653Conserved hypothetical protein; Similar to a fragment of S-adenosyl-methyltransferase mraW. (83 aa)
rpoZDNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (81 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (211 aa)
Your Current Organism:
Aster yellows
NCBI taxonomy Id: 322098
Other names: A. yellows witches'-broom phytoplasma AYWB, Aster yellows witches'-broom phytoplasma AYWB
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